ubiquitin C-terminal hydrolase L1

Target id: 2426

Nomenclature: ubiquitin C-terminal hydrolase L1

Family: C12: Ubiquitin C-terminal hydrolase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ubiquitin C-terminal hydrolase L1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 223 4p13 UCHL1 ubiquitin C-terminal hydrolase L1
Mouse - 223 5 C3.1 Uchl1 ubiquitin carboxy-terminal hydrolase L1
Rat - 223 14p11 Uchl1 ubiquitin C-terminal hydrolase L1
Previous and Unofficial Names
gad | gracile axonal dystrophy | PARK5 | ubiquitin thioesterase L1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Database Links
Specialist databases
MEROPS C12.001 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.19.12

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
LDN-91946 Hs Inhibition 5.6 pKi 1
pKi 5.6 (Ki 2.3x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Neurodegeneration with optic atrophy, childhood onset
Synonyms: Early-onset progressive neurodegeneration - blindness - ataxia - spasticity [Orphanet: ORPHA352654]
OMIM: 615491
Orphanet: ORPHA352654
Disease:  Parkinson disease 5, autosomal dominant; PARK5
Synonyms: Parkinson's disease [Disease Ontology: DOID:14330]
Disease Ontology: DOID:14330
OMIM: 613643
Disease:  Young adult-onset Parkinsonism
Orphanet: ORPHA2828

References

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1. Mermerian AH, Case A, Stein RL, Cuny GD. (2007) Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg. Med. Chem. Lett., 17 (13): 3729-32. [PMID:17449248]

How to cite this page

C12: Ubiquitin C-terminal hydrolase: ubiquitin C-terminal hydrolase L1. Last modified on 29/01/2016. Accessed on 24/05/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2426.