ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Nomenclature: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Family: C12: Ubiquitin C-terminal hydrolase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 223 4p13 UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Mouse - 223 5 C3.1 Uchl1 ubiquitin carboxy-terminal hydrolase L1
Rat - 223 14p11 Uchl1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Previous and Unofficial Names
AW822034
C88048
gad
gracile axonal dystrophy
neuron cytoplasmic protein 9.5
PARK5
PGP 9.5
R75593
ubiquitin carboxy-terminal hydrolase L1
ubiquitin carboxyl-terminal esterase L1
ubiquitin carboxyl-terminal hydrolase isozyme L1
ubiquitin thioesterase L1
Uch-L1
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
InterPro
KEGG BRITE Hierarchy
KEGG Gene
MEROPS
OMIM
Orphanet Gene
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Enzyme Reaction
EC Number: 3.4.19.12
Clinically-Relevant Mutations and Pathophysiology
Disease:  Neurodegeneration with optic atrophy, childhood onset
OMIM:  615491
Orphanet:  352654
References: 
Mutations not determined
Disease:  Parkinson disease 5, autosomal dominant, including young adult-onset Parkinsonism
OMIM:  613643
Orphanet:  2828
References: 
Mutations not determined

The Guide to PHARMACOLOGY curates quantitative bioactivity mappings for all approved, clinical and selected actively pursued research targets. Data for additional protein mappings from medicinal chemistry papers and selected PubChem Bioassays can be found in the ChEMBL links.

How to cite this page

C12: Ubiquitin C-terminal hydrolase: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase). Last modified on 10/03/2014. Accessed on 20/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2426.