Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	230	13q22.2	UCHL3	ubiquitin C-terminal hydrolase L3
Mouse	-	230	14 50.9 cM	Uchl3	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Rat	-	230	15q21	Uchl3	ubiquitin C-terminal hydrolase L3

Previous and Unofficial Names

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Database Links
Specialist databases
MEROPS	C12.003 (Hs)
Other databases
Alphafold	P15374 (Hs), Q9JKB1 (Mm)
BRENDA	3.4.19.12
CATH/Gene3D	3.40.532.10
ChEMBL Target	CHEMBL6195 (Hs)
Ensembl Gene	ENSG00000118939 (Hs), ENSMUSG00000022111 (Mm), ENSRNOG00000009530 (Rn), ENSRNOG00000065893 (Rn)
Entrez Gene	7347 (Hs), 50933 (Mm), 498560 (Rn)
Human Protein Atlas	ENSG00000118939 (Hs)
KEGG Enzyme	3.4.19.12
KEGG Gene	hsa:7347 (Hs), mmu:50933 (Mm), rno:498560 (Rn)
OMIM	603090 (Hs)
Pharos	P15374 (Hs)
RefSeq Nucleotide	NM_006002 (Hs), NM_001270952 (Hs), NM_016723 (Mm), NM_001110165 (Rn)
RefSeq Protein	NP_001257881 (Hs), NP_005993 (Hs), NP_057932 (Mm), NP_001103635 (Rn)
UniProtKB	P15374 (Hs), Q9JKB1 (Mm)
Wikipedia	UCHL3 (Hs)

Enzyme Reaction
EC Number: 3.4.19.12

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 6 [PMID: 17948018] Hs Inhibition 6.2 pIC50 1 ⤷ pIC50 6.2 (IC50 6x10-7 M) [1]

Immuno Process Associations

Immuno Process:  Cellular signalling