aldehyde dehydrogenase 5 family member A1

Target id: 2466

Nomenclature: aldehyde dehydrogenase 5 family member A1

Abbreviated Name: SSADH

Family: GABA turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for aldehyde dehydrogenase 5 family member A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 535 6p22 ALDH5A1 aldehyde dehydrogenase 5 family member A1
Mouse - 523 13 A3.1 Aldh5a1 aldhehyde dehydrogenase family 5
Rat - 523 17p11 Aldh5a1 aldehyde dehydrogenase 5 family
Previous and Unofficial Names
NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH, SSDH | succinate-semialdehyde dehydrogenase, mitochondrial | aldehyde dehydrogenase 5 family, member A1 | aldehyde dehydrogenase 5 family | aldhehyde dehydrogenase family 5, subfamily A1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 4-Oxobutanoate + NAD + H2O = succinic acid + NADH + 2H+
4-hydroxy-trans-2-nonenal + NAD + H2O = 4-hydroxy-trans-2-nonenoate + NADH + 2H+
Cofactor Species Comments Reference
NAD None

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
4-acryloylphenol Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.5x10-7 M) [1]
Inhibitor Comments
This enzyme is inhibited by the approved drug valproic acid.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Succinic semialdehyde dehydrogenase deficiency; SSADHD
Synonyms: 4-hydroxybutyric aciduria [Orphanet: ORPHA22]
Disease Ontology: DOID:0060175
OMIM: 271980
Orphanet: ORPHA22


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1. Tao YH, Yuan Z, Tang XQ, Xu HB, Yang XL. (2006) Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg. Med. Chem. Lett.16 (3): 592-5. [PMID:16290145]

How to cite this page

GABA turnover: aldehyde dehydrogenase 5 family member A1. Last modified on 29/01/2016. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY,