aldehyde dehydrogenase 5 family member A1

Target id: 2466

Nomenclature: aldehyde dehydrogenase 5 family member A1

Abbreviated Name: SSADH

Family: GABA turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for aldehyde dehydrogenase 5 family member A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 535 6p22 ALDH5A1 aldehyde dehydrogenase 5 family member A1
Mouse - 523 13 A3.1 Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1
Rat - 523 17p11 Aldh5a1 aldehyde dehydrogenase 5 family, member A1
Previous and Unofficial Names
NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH, SSDH | succinate-semialdehyde dehydrogenase, mitochondrial | aldehyde dehydrogenase 5 family, member A1 | aldehyde dehydrogenase 5 family
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.2.1.24 4-Oxobutanoate + NAD + H2O = succinic acid + NADH + 2H+
4-hydroxy-trans-2-nonenal + NAD + H2O = 4-hydroxy-trans-2-nonenoate + NADH + 2H+
Cofactors
Cofactor Species Comments Reference
NAD None

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
4-acryloylphenol Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.5x10-7 M) [1]
Inhibitor Comments
This enzyme is inhibited by the approved drug valproic acid.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Succinic semialdehyde dehydrogenase deficiency; SSADHD
Synonyms: 4-hydroxybutyric aciduria [Orphanet: ORPHA22]
Disease Ontology: DOID:0060175
OMIM: 271980
Orphanet: ORPHA22

References

Show »

1. Tao YH, Yuan Z, Tang XQ, Xu HB, Yang XL. (2006) Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg. Med. Chem. Lett.16 (3): 592-5. [PMID:16290145]

How to cite this page

GABA turnover: aldehyde dehydrogenase 5 family member A1. Last modified on 29/01/2016. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2466.