embryonic ectoderm development

Target id: 2487

Nomenclature: embryonic ectoderm development

Family: Neutral sphingomyelinase coupling factors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for embryonic ectoderm development in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 441 11q14.2-q22.3 EED embryonic ectoderm development
Mouse - 441 7 E1 Eed embryonic ectoderm development
Rat - 441 1q32 Eed embryonic ectoderm development
Previous and Unofficial Names
Polycomb protein EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
A-395 Hs Binding 9.4 pKi 1
pKi 9.4 (Ki 4x10-10 M) [1]
General Comments
The EED protein is an essential subunit of the polycomb repressive complex 2 (PRC2). PRC2 trimethylates histone H3 at lysine 27 (H3K27me3) causing gene silencing. H3K27me3 marks are recognised, and the trimethyllysine bound by EED. The small molecule probe A-395 prevents EED binding to H3K27me3 histone marks and this blocks activation of the catalytic activity of PRC2.


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1. He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM et al.. (2017) The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat. Chem. Biol., 13 (4): 389-395. [PMID:28135237]

How to cite this page

Neutral sphingomyelinase coupling factors: embryonic ectoderm development. Last modified on 05/04/2017. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2487.