thyroid peroxidase

Target id: 2526

Nomenclature: thyroid peroxidase

Abbreviated Name: TPO

Family: Thyroid hormone turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for thyroid peroxidase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 933 2p25 TPO thyroid peroxidase
Mouse - 914 12 C Tpo thyroid peroxidase
Rat - 914 6q16 Tpo thyroid peroxidase
Previous and Unofficial Names
Iodide peroxidase | TPX
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.11.1.8 [Thyroglobulin]-L-tyrosine + H2O2 + H+ + I- -> [Thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O
Cofactors
Cofactor Species Comments Reference
Ca2+ Human Intracellular

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
methimazole Hs Inhibition - - 1
[1]
propylthiouracil Hs Inhibition - - 1
[1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Thyroid dyshormonogenesis 2A; TDH2A
OMIM: 274500
Orphanet: ORPHA95716

References

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1. Nakashima T, Taurog A, Riesco G. (1978) Mechanism of action of thioureylene antithyroid drugs: factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats. Endocrinology103 (6): 2187-97. [PMID:748042]

How to cite this page

Thyroid hormone turnover: thyroid peroxidase. Last modified on 07/03/2014. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2526.