thyroid peroxidase

Target id: 2526

Nomenclature: thyroid peroxidase

Abbreviated Name: TPO

Family: Thyroid hormone turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for thyroid peroxidase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 933 2p25 TPO thyroid peroxidase
Mouse - 914 12 C Tpo thyroid peroxidase
Rat - 914 6q16 Tpo thyroid peroxidase
Previous and Unofficial Names
Iodide peroxidase | TPX
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.11.1.8 [Thyroglobulin]-L-tyrosine + H2O2 + H+ + I- -> [Thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O
Cofactors
Cofactor Species Comments Reference
Ca2+ Human Intracellular

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
methimazole Hs Inhibition - - 1
[1]
propylthiouracil Hs Inhibition - - 1
[1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Thyroid dyshormonogenesis 2A; TDH2A
OMIM: 274500
Orphanet: ORPHA95716

References

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1. Nakashima T, Taurog A, Riesco G. (1978) Mechanism of action of thioureylene antithyroid drugs: factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats. Endocrinology, 103 (6): 2187-97. [PMID:748042]

How to cite this page

Thyroid hormone turnover: thyroid peroxidase. Last modified on 07/03/2014. Accessed on 21/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2526.