tyrosinase

Target id: 2643

Nomenclature: tyrosinase

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for tyrosinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 529 11q14.3 TYR tyrosinase
Mouse - 533 7 D3-E1 Tyr tyrosinase
Rat - 530 1q32 Tyr tyrosinase
Previous and Unofficial Names
OCA1A | OCAIA
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.18.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 7 [PMID: 21334791] ? Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 3.7x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Melanoma, cutaneous malignant, susceptibility to, 8; CMM8
OMIM: 601800
Disease:  Minimal pigment oculocutaneous albinism type 1
Orphanet: ORPHA352734
Disease:  Ocular albinism with congenital sensorineural deafness
OMIM: 103470
Orphanet: ORPHA352740
Disease:  Oculocutaneous albinism type 1A
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 203100
Orphanet: ORPHA79431
Disease:  Oculocutaneous albinism type 1B
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 606952
Orphanet: ORPHA79434
Disease:  Temperature-sensitive oculocutaneous albinism type 1
OMIM: 606952
Orphanet: ORPHA352737

References

Show »

1. Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei H, Yamada Y, Masuoka N, Nihei K. (2011) Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem46 (4): 1374-81. [PMID:21334791]

How to cite this page

1.-.-.- Oxidoreductases: tyrosinase. Last modified on 16/09/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2643.