tyrosinase

Target id: 2643

Nomenclature: tyrosinase

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for tyrosinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 529 11q14.3 TYR tyrosinase
Mouse - 533 7 D3-E1 Tyr tyrosinase
Rat - 530 1q32 Tyr tyrosinase
Previous and Unofficial Names
OCA1A | OCAIA
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.18.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 7 [PMID: 21334791] ? Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 3.7x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Melanoma, cutaneous malignant, susceptibility to, 8; CMM8
OMIM: 601800
Disease:  Minimal pigment oculocutaneous albinism type 1
Orphanet: ORPHA352734
Disease:  Ocular albinism with congenital sensorineural deafness
OMIM: 103470
Orphanet: ORPHA352740
Disease:  Oculocutaneous albinism type 1A
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 203100
Orphanet: ORPHA79431
Disease:  Oculocutaneous albinism type 1B
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 606952
Orphanet: ORPHA79434
Disease:  Temperature-sensitive oculocutaneous albinism type 1
OMIM: 606952
Orphanet: ORPHA352737

References

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1. Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei H, Yamada Y, Masuoka N, Nihei K. (2011) Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem, 46 (4): 1374-81. [PMID:21334791]

How to cite this page

1.-.-.- Oxidoreductases: tyrosinase. Last modified on 16/09/2015. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2643.