lysine demethylase 6B

Target id: 2685

Nomenclature: lysine demethylase 6B

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for lysine demethylase 6B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1682 17p13.1 KDM6B lysine demethylase 6B
Mouse - 1641 11 B3 Kdm6b KDM1 lysine (K)-specific demethylase 6B
Rat - 1361 10q24 Kdm6b lysine demethylase 6B
Previous and Unofficial Names
JMJD3 | KDM1 lysine (K)-specific demethylase 6B | lysine (K)-specific demethylase 6B
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GSK-J1 Hs Inhibition 7.2 – 7.6 pIC50 1-2
pIC50 7.2 – 7.6 (IC50 6x10-8 – 2.8x10-8 M) [1-2]
IOX1 Hs Inhibition 5.8 pIC50 3
pIC50 5.8 (IC50 1.6x10-6 M) [3]
GSK-J4 Hs Inhibition 5.1 pIC50 1
pIC50 5.1 (IC50 8.6x10-6 M) [1]

References

Show »

1. Heinemann B, Nielsen JM, Hudlebusch HR, Lees MJ, Larsen DV, Boesen T, Labelle M, Gerlach LO, Birk P, Helin K. (2014) Inhibition of demethylases by GSK-J1/J4. Nature514 (7520): E1-2. [PMID:25279926]

2. Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H et al.. (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature488 (7411): 404-8. [PMID:22842901]

3. Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC et al.. (2014) A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem9 (3): 566-71. [PMID:24504543]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 6B. Last modified on 30/03/2016. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2685.