CysLT<sub>1</sub> receptor | Leukotriene receptors | IUPHAR/BPS Guide to PHARMACOLOGY

CysLT1 receptor

Target id: 269

Nomenclature: CysLT1 receptor

Family: Leukotriene receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     CysLT1 receptor has curated GtoImmuPdb data

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 Xq13.2-21.1 CYSLTR1 cysteinyl leukotriene receptor 1 39,75
Mouse 7 352 X D Cysltr1 cysteinyl leukotriene receptor 1
Rat 7 339 Xq31 Cysltr1 cysteinyl leukotriene receptor 1
Previous and Unofficial Names
HG55 | LTD4 | CYSLT1R | leukotriene D4 receptor
Database Links
Specialist databases
GPCRDB cltr1_human (Hs), cltr1_mouse (Mm), cltr1_rat (Rn)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
LTC4
LTD4
LTE4
Comments: LTD4 is the most potent endogenous agonist
Potency order of endogenous ligands
LTD4 > LTC4 > LTE4  [39,75]

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]LTD4 Hs Full agonist 8.2 – 10.6 pKd 10-13,39
pKd 8.6 – 10.6 Kd1 and Kd2 in human lung parenchyma [11-12]
pKd 9.3 (Kd 5x10-10 M) in U937 cells [10]
pKd 8.2 – 10.2 Kd1 and Kd2 in COS-7 cells [13,39]
LTC4 Hs Full agonist 7.0 – 8.1 pKi 12
pKi 7.0 – 8.1 Ki1 and Ki2 against [3H]LTD4 in human lung parenchyma [12]
LTE4 Hs Partial agonist 7.1 – 7.8 pKi 12
pKi 7.1 – 7.8 Ki against [3H]LTD4 in human lung parenchyma [12]
LTD4 Hs Full agonist 7.3 – 9.4 pEC50 10,15,39,55,75,82,84
pEC50 9.4 (EC50 4x10-10 M) pigment dispersion in X. laevis melanophores [39]
pEC50 8.5 (EC50 3x10-9 M) Ca2+ activated chloride conductance in X. laevis oocytes [39]
pEC50 8.5 (EC50 3.4x10-9 M) Ca2+ mobilisation assay in U937 cells [10]
pEC50 7.3 – 9.2 (EC50 4.6x10-8 – 6x10-10 M) Ca2+ mobilisation assay in COS-7 or HEK-293 cells [15,39,55,75,82,84]
LTC4 Hs Full agonist 7.4 – 7.7 pEC50 39,55,75,82
pEC50 7.7 (EC50 2.1x10-8 M) pigment dispersion in X. laevis melanophores [39]
pEC50 7.4 – 7.7 (EC50 4.3x10-8 – 2x10-8 M) Ca2+ mobilisation assay in COS-7 or HEK-293 cells [55,75,82]
LTE4 Hs Partial agonist 6.4 – 7.2 pEC50 39,55,75,82,92
pEC50 6.6 – 7.2 (EC50 2.4x10-7 – 5.8x10-8 M) Ca2+ mobilisation assay in COS-7 or HEK-293 cells [55,75,82]
pEC50 6.7 (EC50 2.12x10-7 M) pigment dispersion in X. laevis melanophores [39]
pEC50 6.4 (EC50 3.91x10-7 M) aequorin-based Ca2+ assay in HEK-293 cells [92]
N-methyl LTC4 Hs Partial agonist 5.7 pEC50 92
pEC50 5.7 (EC50 2x10-6 M) aequorin-based Ca2+ assay in HEK-293 cells [92]
LTD4 Hs Full agonist 8.1 pIC50 75
pIC50 8.1 (IC50 9x10-9 M) against [3H]LTD4 in HEK-293 cells [75]
LTE4 Hs Partial agonist 6.6 – 7.0 pIC50 39
pIC50 6.6 – 7.0 (IC50 2.74x10-7 – 1.07x10-7 M) against [3H]LTD4 in COS-7 cells [39]
LTC4 Hs Full agonist 6.4 – 6.5 pIC50 39
pIC50 6.4 – 6.5 (IC50 3.6x10-7 – 3.46x10-7 M) against [3H]LTD4 in COS-7 cells [39]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
triple modulator 10 [PMID: 29878767] Hs Antagonist 8.7 pA2 77
pA2 8.7 [77]
BayCysLT2 Hs Antagonist 6.4 pA2 15
pA2 6.4 against LTD4 Ca2+ mobilisation assay in COS-7 cells [15]
[3H]ICI-198615 Hs Antagonist 10.6 pKd 72
pKd 10.6 (Kd 2.5x10-11 M) in human lung parenchyma [72]
zafirlukast Hs Antagonist 8.9 pKi 11,70
pKi 8.9 against [3H]LTD4 in human lung parenchyma [11,70]
montelukast Hs Antagonist 8.6 pKi 70
pKi 8.6 against [3H]LTD4 in human lung parenchyma [70]
pranlukast Hs Antagonist 7.1 – 8.8 pKi 11,70
pKi 7.1 – 8.8 against [3H]LTD4 in human lung parenchyma [11,70]
iralukast Hs Antagonist 7.8 pKi 11
pKi 7.8 against [3H]LTD4 in human lung parenchyma [11]
pobilukast Hs Antagonist 7.1 pKi 12
pKi 7.1 against [3H]LTD4 in human lung parenchyma [12]
pranlukast Hs Antagonist 8.1 – 10.0 pIC50 39,75
pIC50 10.0 (IC50 1x10-10 M) against 33nM LTD4 Ca2+ mobilization assay in HEK-293 [75]
pIC50 8.1 – 8.4 (IC50 7.2x10-9 – 4.3x10-9 M) against [3H]LTD4 in COS-7 or HEK-293 cells [39,75]
zafirlukast Hs Antagonist 7.7 – 9.6 pIC50 39,75,91
pIC50 9.6 (IC50 2.6x10-10 M) against 33nM LTD4 Ca2+ mobilization assay in HEK-293 [75]
pIC50 8.6 – 8.7 (IC50 2.6x10-9 – 1.8x10-9 M) against [3H]LTD4 in COS-7 or HEK-293 cells [39,75]
pIC50 7.7 (IC50 2x10-8 M) against 10nM LTD4 aequorin-based Ca2+ assay in CHO cells [91]
montelukast Hs Antagonist 8.3 – 8.6 pIC50 39,75
pIC50 8.6 (IC50 2.3x10-9 M) against 33nM LTD4 Ca2+ mobilization assay in HEK-293 [75]
pIC50 8.3 – 8.6 (IC50 4.9x10-9 – 2.3x10-9 M) against [3H]LTD4 in COS-7 or HEK-293 cells [39,75]
verlukast Hs Antagonist 8.0 pIC50 39
pIC50 8.0 (IC50 1x10-8 M) against [3H]LTD4 in COS-7 cells [39]
pobilukast Hs Antagonist 7.5 – 8.3 pIC50 75
pIC50 8.3 (IC50 5.5x10-9 M) against 33nM LTD4 Ca2+ mobilization assay in HEK-293 [75]
pIC50 7.5 (IC50 3x10-8 M) against [3H]LTD4 in HEK-293 [75]
BAYu9773 Hs Antagonist 5.3 – 6.4 pIC50 55,91
pIC50 6.4 (IC50 4.4x10-7 M) against 10nM LTD4 Ca2+ mobilization assay in HEK-293 [55]
pIC50 5.3 (IC50 5x10-6 M) against 10nM LTD4 aequorin-based Ca2+ assay in CHO cells [91]
Immunopharmacology Comments
CysLT1 is a receptor for cysteinyl-leukotrienes. Both CysLT1 and CysLT2 mediate cysteinyl-leukotriene-induced modulation of smooth muscle cell contraction, regulation of vascular permeability, and leukocyte activation.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002437 inflammatory response to antigenic stimulus IEA
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Comments:  PI turnover and Ca2+ mobilisation. A number of different groups have reported a Gq/G11-dependent Ca2+ mobilization in monocytic leukemia U937 [10,65,89] or THP-1 cells [16,31], mast cells [51] or monocyte-derived macrophages [40]
References:  39,75
Secondary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Phospholipase C stimulation
Comments:  Other different cellular responses have been reported to be Gi/G0 coupled [2,4,14,21,31,36,60,62,71,73,76,79,90].
References:  10,65,78
Tissue Distribution
Nasal polyps
Species:  Human
Technique: 
References:  17,69
Bronchiole smooth muscle, lung macrophages
Species:  Human
Technique:  In situ hybridisation, RT-PCR
References:  39
Peripheral blood leukocytes, spleen, lung, bronchus, small intestine and placenta
Species:  Human
Technique:  Northern blot
References:  39,75
Blood-derived monocytes/macrophages and U937 cells
Species:  Human
Technique:  RT-PCR
References:  13,40
Mast cells
Species:  Human
Technique:  RT-PCR and FACS
References:  51
Platelets
Species:  Human
Technique:  RT-PCR, Western blot and FACS
References:  29
Airway mucosa
Species:  Human
Technique: 
References:  94
Leukocytes
Species:  Human
Technique:  Immunohistochemistry
References:  25
Human saphenous vein
Species:  Human
Technique:  RT-PCR
References:  48
Small intestines and colon
Species:  Human
Technique: 
References:  39,75
Colorectal carcinoma cells
Species:  Human
Technique: 
References:  56
Coronary artery smooth muscle cells
Species:  Human
Technique:  RT-PCR and immunocytochemistry
References:  23
Aortic valves
Species:  Human
Technique:  RT-PCR
References:  54
Functional Assays
Activation of mitogen-activated protein kinase (MAPK)
Species:  Human
Tissue:  THP-1 and U937, intestinal epithelial, Caco-2, airway smooth muscle and mast cells, peripheral blood monocytes/macrophages and chronic lymphocytic leukemia cells
Response measured:  ERK phosphorylation
References:  14,21,30-31,36,59,62,71
Activation of mitogen-activated protein kinase (MAPK)
Species:  Rat
Tissue:  Astrocytes
Response measured:  ERK phosphorylation
References:  18
Activation of pigment dispersion transfected with the human CysLT1 receptor
Species:  Human
Tissue:  X. laevis melanophores
Response measured:  Pigment dispersion
References:  39
Ca2+-activated chloride conductance in oocytes injected with human CysLT1 receptor
Species:  Human
Tissue:  X. laevis oocyte
Response measured:  Cl current
References:  39
Measurement of Ca2+ mobilization in HEK293 or COS-7 cells transfected with the human CysLT1 receptor
Species:  Human
Tissue:  HEK293 - COS-7
Response measured:  [Ca2+]i increase
References:  15,39,55,75,82,84
Physiological Functions
Bronchoconstriction
Species:  Human
Tissue:  Bronchi
References:  1,3,19-20,28,37,80,88
Cell proliferation
Species:  Human
Tissue:  Airway smooth muscle and epithelial cells, intestinal epithelial, Caco-2, eosinophil hematopoietic progenitor and mast cells, fibrocytes, prostate cancer and chronic lymphocytic leukemia cells
References:  7-9,21,24,36,46,57,59,63-64,71,86
Chemotactic activity and migration
Species:  Human
Tissue:  THP-1, hematopoietic stem and airway smooth muscle cells, eosinophils,intestinal epithelial cells, monocytes/macrophages, Th2 and chronic lymphocytic leukemia cells
References:  4,21,26,31,58,60-61,87,90
Actin reorganization
Species:  Human
Tissue:  Bronchial smooth muscle and intestinal epithelial cells
References:  42,44,73
Release of inflammatory mediators and cytokines
Species:  Human
Tissue:  U937, THP-1 and dendritic cells, eosinophils, blood mononuclear cells, macrophages and monocytes, airway epithelial cells, platelets and fibroblast
References:  2,8,22,26-27,29-30,33-35,47,64,68,83
Cell adhesion
Species:  Human
Tissue:  U937, intestinal epithelial and Caco-2 cells, eosinophils, hematopoietic stem and progenitor cells, polymorphonuclear leukocytes
References:  7,38,43,45,49-50,67,79
Activation of transcription factors
Species:  Human
Tissue:  THP-1 and dendritic cells, eosinophils, epithelial cells, peripheral blood monocytes/macrophages
References:  6,30,67,81,83
Cell proliferation
Species:  Rat
Tissue:  Vascular smooth muscle cells and astrocytes
References:  18,32,66
Physiological Functions Comments
Some physiological functions in cells expressing both CysLT1 and CysLT2 (e.g. eosinophils chemotaxis and adhesion) have been attributed to CysLT1 on the base of antagonist effect [52-53,74,85] However, most leukotriene receptor antagonist, but montelukast and MK-571, are also active at the CysLT2 and, thus, preclude unambiguous identification.
Physiological Consequences of Altering Gene Expression
Transgenic mice overexpressing the human CysLT1R in SMCs via the α-actin promoter exhibit significantly enhanced allergen-induced airway hyperresponsiveness following LTD4 challenge.
Species:  Mouse
Tissue:  Lung
Technique:  Gene overexpression, hCysLT1R transgene injected embryos
References:  93
CysLT1 receptor knockout mice exhibit aggravated bleomycin-induced pulmonary inflammation.
Species:  Mouse
Tissue:  Lung
Technique:  Gene knockouts
References:  5
CysLT1 receptor knockout mice exhibit significantly suppressed plasma protein extravasation, but not neutrophil infiltration, after zymosan-induced peritonitis or IgE-mediated passive cutaneous anaphylaxis
Species:  Mouse
Tissue: 
Technique:  Gene knockouts
References:  41
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Cysltr1tm1Ykn Cysltr1tm1Ykn/Cysltr1tm1Ykn
involves: C57BL/6
MGI:1926218  MP:0005621 abnormal cell physiology PMID: 11932261 
Cysltr1tm1Ykn Cysltr1tm1Ykn/Cysltr1tm1Ykn
involves: C57BL/6
MGI:1926218  MP:0005597 decreased susceptibility to type I hypersensitivity reaction PMID: 11932261 
Cysltr1tm1Ykn Cysltr1tm1Ykn/Cysltr1tm1Ykn
involves: C57BL/6
MGI:1926218  MP:0003071 decreased vascular permeability PMID: 11932261 
Cysltr1tm1Ykn Cysltr1tm1Ykn/Cysltr1tm1Ykn
involves: C57BL/6
MGI:1926218  MP:0002405 respiratory system inflammation PMID: 14970333 
General Comments
LTE4 may be the only selective agonist as LTC4 and LTD4 also activate CysLT2 receptors. However, when Ca2+ mobilisation is studied in transfected cells, LTE4 is much less potent than LTD4.

References

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1. Adelroth E, Morris MM, Hargreave FE, O'Byrne PM. (1986) Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. N. Engl. J. Med., 315 (8): 480-4. [PMID:3526153]

2. Bandeira-Melo C, Hall JC, Penrose JF, Weller PF. (2002) Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. J. Allergy Clin. Immunol., 109 (6): 975-9. [PMID:12063527]

3. Barnes NC, Piper PJ, Costello JF. (1984) Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. Thorax, 39 (7): 500-4. [PMID:6463929]

4. Bautz F, Denzlinger C, Kanz L, Möhle R. (2001) Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. Blood, 97 (11): 3433-40. [PMID:11369634]

5. Beller TC, Friend DS, Maekawa A, Lam BK, Austen KF, Kanaoka Y. (2004) Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc. Natl. Acad. Sci. U.S.A., 101 (9): 3047-52. [PMID:14970333]

6. Bengtsson AM, Massoumi R, Sjölander A. (2008) Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. Prostaglandins Other Lipid Mediat., 85 (3-4): 100-6. [PMID:18083053]

7. Boehmler AM, Drost A, Jaggy L, Seitz G, Wiesner T, Denzlinger C, Kanz L, Möhle R. (2009) The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. J. Immunol., 182 (11): 6789-98. [PMID:19454674]

8. Bossé Y, Thompson C, McMahon S, Dubois CM, Stankova J, Rola-Pleszczynski M. (2008) Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. Clin. Exp. Allergy, 38 (1): 113-21. [PMID:18028462]

9. Braccioni F, Dorman SC, O'byrne PM, Inman MD, Denburg JA, Parameswaran K, Baatjes AJ, Foley R, Gauvreau GM. (2002) The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. J. Allergy Clin. Immunol., 110 (1): 96-101. [PMID:12110827]

10. Capra V, Accomazzo MR, Ravasi S, Parenti M, Macchia M, Nicosia S, Rovati GE. (2003) Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. Prostaglandins Other Lipid Mediat., 71 (3-4): 235-51. [PMID:14518564]

11. Capra V, Bolla M, Belloni PA, Mezzetti M, Folco GC, Nicosia S, Rovati GE. (1998) Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. Br. J. Pharmacol., 123 (3): 590-8. [PMID:9504401]

12. Capra V, Nicosia S, Ragningi D, Mezette M, Keppler D, Rovati GE. (1998) Identifiction and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. Mol. Pharmacol., 53: 750-758. [PMID:9547367]

13. Capra V, Ravasi S, Accomazzo MR, Citro S, Grimoldi M, Abbracchio MP, Rovati GE. (2005) CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J. Cell. Sci., 118 (Pt 23): 5625-36. [PMID:16306225]

14. Capra V, Ravasi S, Accomazzo MR, Parenti M, Rovati GE. (2004) CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. Biochem. Pharmacol., 67 (8): 1569-77. [PMID:15041474]

15. Carnini C, Accomazzo MR, Borroni E, Vitellaro-Zuccarello L, Durand T, Folco G, Rovati GE, Capra V, Sala A. (2011) Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. FASEB J., 25 (10): 3519-28. [PMID:21753081]

16. Chan CC, Ecclestone P, Nicholson DW, Metters KM, Pon DJ, Rodger IW. (1994) Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists. J. Pharmacol. Exp. Ther., 269 (3): 891-6. [PMID:8014876]

17. Chao SS, Graham SM, Brown CL, Kline JN, Hussain I. (2006) Cysteinyl leukotriene 1 receptor expression in nasal polyps. Ann. Otol. Rhinol. Laryngol., 115 (5): 394-7. [PMID:16739673]

18. Ciccarelli R, D'Alimonte I, Santavenere C, D'Auro M, Ballerini P, Nargi E, Buccella S, Nicosia S, Folco G, Caciagli F et al.. (2004) Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway. Eur. J. Neurosci., 20 (6): 1514-24. [PMID:15355318]

19. Davidson AB, Lee TH, Scanlon PD, Solway J, McFadden Jr ER, Ingram Jr RH, Corey EJ, Austen KF, Drazen JM. (1987) Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. Am. Rev. Respir. Dis., 135 (2): 333-7. [PMID:3028218]

20. Drazen JM, Austen KF, Lewis RA, Clark DA, Goto G, Marfat A, Corey EJ. (1980) Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc. Natl. Acad. Sci. U S A., 77: 4354-4358. [PMID:6933488]

21. Drost AC, Seitz G, Boehmler A, Funk M, Norz KP, Zipfel A, Xue X, Kanz L, Möhle R. (2012) The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia. Leuk. Lymphoma, 53 (4): 665-73. [PMID:21936770]

22. Eap R, Jacques E, Semlali A, Plante S, Chakir J. (2012) Cysteinyl leukotrienes regulate TGF-β(1) and collagen production by bronchial fibroblasts obtained from asthmatic subjects. Prostaglandins Leukot. Essent. Fatty Acids, 86 (3): 127-33. [PMID:22316690]

23. Eaton A, Nagy E, Pacault M, Fauconnier J, Bäck M. (2012) Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. J. Mol. Med., 90 (10): 1223-31. [PMID:22527886]

24. Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M. (2003) CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J. Allergy Clin. Immunol., 111 (5): 1032-40. [PMID:12743568]

25. Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP et al.. (2001) Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. Am. J. Respir. Crit. Care Med., 163 (1): 226-33. [PMID:11208650]

26. Fregonese L, Silvestri M, Sabatini F, Rossi GA. (2002) Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism. Clin. Exp. Allergy, 32 (5): 745-50. [PMID:11994100]

27. Frieri M, Therattil J, Wang SF, Huang CY, Wang YC. (2003) Montelukast inhibits interleukin-5 mRNA expression and cysteinyl leukotriene production in ragweed and mite-stimulated peripheral blood mononuclear cells from patients with asthma. Allergy Asthma Proc, 24 (5): 359-66. [PMID:14619337]

28. Griffin M, Weiss JW, Leitch AG, McFadden Jr ER, Corey EJ, Austen KF, Drazen JM. (1983) Effects of leukotriene D on the airways in asthma. N. Engl. J. Med., 308 (8): 436-9. [PMID:6823253]

29. Hasegawa S, Ichiyama T, Hashimoto K, Suzuki Y, Hirano R, Fukano R, Furukawa S. (2010) Functional expression of cysteinyl leukotriene receptors on human platelets. Platelets, 21 (4): 253-9. [PMID:20433311]

30. Hashimoto K, Ichiyama T, Hasegawa M, Hasegawa S, Matsubara T, Furukawa S. (2009) Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. Int. Arch. Allergy Immunol., 149 (3): 275-82. [PMID:19218821]

31. Hoshino M, Izumi T, Shimizu T. (1998) Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. J. Biol. Chem., 273 (9): 4878-82. [PMID:9478929]

32. Huang XJ, Zhang WP, Li CT, Shi WZ, Fang SH, Lu YB, Chen Z, Wei EQ. (2008) Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. Glia, 56 (1): 27-37. [PMID:17910051]

33. Ichiyama T, Hasegawa M, Hashimoto K, Matsushige T, Hirano R, Furukawa S. (2009) Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages. Int. Arch. Allergy Immunol., 148 (2): 147-53. [PMID:18802359]

34. Ichiyama T, Hasegawa M, Ueno Y, Makata H, Matsubara T, Furukawa S. (2005) Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. Clin. Exp. Allergy, 35 (9): 1214-9. [PMID:16164450]

35. Ichiyama T, Kajimoto M, Hasegawa M, Hashimoto K, Matsubara T, Furukawa S. (2007) Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages. Clin. Exp. Allergy, 37 (4): 608-14. [PMID:17430359]

36. Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JA. (2006) Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J. Immunol., 177 (5): 2755-9. [PMID:16920908]

37. Kern R, Smith LJ, Patterson R, Krell RD, Bernstein PR. (1986) Characterization of the airway response to inhaled leukotriene D4 in normal subjects. Am. Rev. Respir. Dis., 133 (6): 1127-32. [PMID:3521417]

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Magnus Bäck, G. Enrico Rovati, Sven-Erik Dahlén, Jeffrey Drazen, Jilly F. Evans, Takao Shimizu, Charles N. Serhan, Takehiko Yokomizo.
Leukotriene receptors: CysLT1 receptor. Last modified on 25/06/2018. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=269.