SET domain containing lysine methyltransferase 7

Target id: 2703

Nomenclature: SET domain containing lysine methyltransferase 7

Family: 2.1.1.43 Histone methyltransferases (HMTs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for SET domain containing lysine methyltransferase 7 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 366 4q31.1 SETD7 SET domain containing lysine methyltransferase 7
Mouse - 366 3 C Setd7 SET domain containing (lysine methyltransferase) 7
Rat - 366 2q26 Setd7 SET domain containing (lysine methyltransferase) 7
Previous and Unofficial Names
KMT7 | SET7/9 | SET domain containing (lysine methyltransferase) 7
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.1.1.43

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
(R)-PFI-2 Hs Inhibition 9.5 pKi 1
pKi 9.5 (Ki 3.3x10-10 M) [1]

References

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1. Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA et al.. (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc. Natl. Acad. Sci. U.S.A.111 (35): 12853-8. [PMID:25136132]

How to cite this page

2.1.1.43 Histone methyltransferases (HMTs): SET domain containing lysine methyltransferase 7. Last modified on 30/03/2016. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2703.