bromodomain adjacent to zinc finger domain 2B

Target id: 2722

Nomenclature: bromodomain adjacent to zinc finger domain 2B

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bromodomain adjacent to zinc finger domain 2B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2186 2q24.2 BAZ2B bromodomain adjacent to zinc finger domain 2B
Mouse - 2123 2 C1.1 Baz2b bromodomain adjacent to zinc finger domain, 2B
Rat - 2191 3q21 Baz2b bromodomain adjacent to zinc finger domain, 2B
Previous and Unofficial Names
WALp4 | bromodomain adjacent to zinc finger domain, 2B | bromodomain adjacent to zinc finger domain
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the bromodomain of human BAZ2B in complex WITH GSK2801
PDB Id:  4RVR
Ligand:  GSK2801
Resolution:  1.98Å
Species:  Human
References: 
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the bromodomain of human BAZ2B in complex with E11919 BAZ2-ICR analogue
PDB Id:  4XUA
Ligand:  compound 1 [PMID: 25719566]
Resolution:  1.75Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the bromodomain of human BAZ2B in complex with BAZ2-ICR chemical probe
PDB Id:  4XUB
Ligand:  compound 7 [PMID: 25719566]
Resolution:  1.98Å
Species:  Human
References:  1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GSK2801 Hs Binding 6.9 pKd 2
pKd 6.9 (Kd 1.36x10-7 M) [2]
Description: Isothermal titration calorimetry (ITC) assay
BAZ2-ICR Hs Inhibition 6.8 pKd 1
pKd 6.8 (Kd 1.7x10-7 M) [1]
Description: Isothermal titration calorimetry (ITC) assay
compound 7 [PMID: 25719566] Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1.1x10-6 M) [1]
compound 1 [PMID: 25719566] Hs Inhibition 4.6 pIC50 1
pIC50 4.6 (IC50 2.6x10-5 M) [1]

References

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1. Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M et al.. (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J. Med. Chem., 58 (5): 2553-9. [PMID:25719566]

2. SGC. GSK2801: A Selective Chemical Probe for BAZ2B/A bromodomains. Accessed on 03/03/2015. Modified on 03/03/2015. thesgc.org, http://www.thesgc.org/chemical-probes/GSK2801

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain adjacent to zinc finger domain 2B. Last modified on 29/01/2016. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2722.