bromodomain adjacent to zinc finger domain 2B

Target id: 2722

Nomenclature: bromodomain adjacent to zinc finger domain 2B

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bromodomain adjacent to zinc finger domain 2B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2186 2q24.2 BAZ2B bromodomain adjacent to zinc finger domain 2B
Mouse - 2123 2 C1.1 Baz2b bromodomain adjacent to zinc finger domain, 2B
Rat - 2191 3q21 Baz2b bromodomain adjacent to zinc finger domain, 2B
Previous and Unofficial Names
WALp4 | bromodomain adjacent to zinc finger domain, 2B | bromodomain adjacent to zinc finger domain
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the bromodomain of human BAZ2B in complex WITH GSK2801
PDB Id:  4RVR
Ligand:  GSK2801
Resolution:  1.98Å
Species:  Human
References: 
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the bromodomain of human BAZ2B in complex with E11919 BAZ2-ICR analogue
PDB Id:  4XUA
Ligand:  compound 1 [PMID: 25719566]
Resolution:  1.75Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the bromodomain of human BAZ2B in complex with BAZ2-ICR chemical probe
PDB Id:  4XUB
Ligand:  compound 7 [PMID: 25719566]
Resolution:  1.98Å
Species:  Human
References:  1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GSK2801 Hs Binding 6.9 pKd 2
pKd 6.9 (Kd 1.36x10-7 M) [2]
Description: Isothermal titration calorimetry (ITC) assay
BAZ2-ICR Hs Inhibition 6.8 pKd 1
pKd 6.8 (Kd 1.7x10-7 M) [1]
Description: Isothermal titration calorimetry (ITC) assay
compound 7 [PMID: 25719566] Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1.1x10-6 M) [1]
compound 1 [PMID: 25719566] Hs Inhibition 4.6 pIC50 1
pIC50 4.6 (IC50 2.6x10-5 M) [1]

References

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1. Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M et al.. (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J. Med. Chem.58 (5): 2553-9. [PMID:25719566]

2. SGC. GSK2801: A Selective Chemical Probe for BAZ2B/A bromodomains. Accessed on 03/03/2015. Modified on 03/03/2015. thesgc.org, http://www.thesgc.org/chemical-probes/GSK2801

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain adjacent to zinc finger domain 2B. Last modified on 29/01/2016. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2722.