bromodomain testis associated

Target id: 2729

Nomenclature: bromodomain testis associated

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bromodomain testis associated in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 951 1p22.1 BRDT bromodomain testis associated
Mouse - 956 5 E5 Brdt bromodomain, testis-specific
Rat - 326 14p22 Brdt bromodomain testis associated
Previous and Unofficial Names
BRD6 | CT9 | cancer/testis antigen 9 | bromodomain, testis-specific
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1
PDB Id:  4FLP
Ligand:  (+)-JQ1
Resolution:  2.23Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
XD14 Hs Inhibition 5.9 pKd 1
pKd 5.9 (Kd 1.2x10-6 M) [1]
Description: Assay using recombinant BRDT-BD1.
(+)-JQ1 Mm Inhibition 8.0 pIC50 2
pIC50 8.0 (IC50 1x10-8 M) [2]
Description: Inhibition of H4Kac4 binding to mBRDT-BD1
(+)-JQ1 Hs Inhibition 8.0 pIC50 2
pIC50 8.0 (IC50 1.1x10-8 M) [2]
Description: Inhibition of H4Kac4 binding to hBRDT-BD1
View species-specific inhibitor tables
Inhibitor Comments
(+)-JQ1 inhibits BET family epigenetic reader proteins, such as BRD4 and BRDT.

References

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1. Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S. (2013) 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew. Chem. Int. Ed. Engl.52 (52): 14055-9. [PMID:24272870]

2. Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J et al.. (2012) Small-molecule inhibition of BRDT for male contraception. Cell150 (4): 673-84. [PMID:22901802]

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain testis associated. Last modified on 13/02/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2729.