bromodomain testis associated

Target id: 2729

Nomenclature: bromodomain testis associated

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bromodomain testis associated in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 951 1p22.1 BRDT bromodomain testis associated
Mouse - 956 5 E5 Brdt bromodomain, testis-specific
Rat - 326 14p22 Brdt bromodomain testis associated
Previous and Unofficial Names
BRD6 | CT9 | cancer/testis antigen 9 | bromodomain, testis-specific | bromodomain
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1
PDB Id:  4FLP
Ligand:  (+)-JQ1
Resolution:  2.23Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
XD14 Hs Inhibition 5.9 pKd 1
pKd 5.9 (Kd 1.2x10-6 M) [1]
Description: Assay using recombinant BRDT-BD1.
(+)-JQ1 Mm Inhibition 8.0 pIC50 2
pIC50 8.0 (IC50 1x10-8 M) [2]
Description: Inhibition of H4Kac4 binding to mBRDT-BD1
(+)-JQ1 Hs Inhibition 8.0 pIC50 2
pIC50 8.0 (IC50 1.1x10-8 M) [2]
Description: Inhibition of H4Kac4 binding to hBRDT-BD1
View species-specific inhibitor tables
Inhibitor Comments
(+)-JQ1 inhibits BET family epigenetic reader proteins, such as BRD4 and BRDT.

References

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1. Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S. (2013) 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew. Chem. Int. Ed. Engl., 52 (52): 14055-9. [PMID:24272870]

2. Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J et al.. (2012) Small-molecule inhibition of BRDT for male contraception. Cell, 150 (4): 673-84. [PMID:22901802]

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain testis associated. Last modified on 13/02/2017. Accessed on 20/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2729.