CECR2, histone acetyl-lysine reader

Target id: 2733

Nomenclature: CECR2, histone acetyl-lysine reader

Family: Non-enzymatic BRD containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CECR2, histone acetyl-lysine reader in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1464 22q11.2 CECR2 CECR2, histone acetyl-lysine reader
Mouse - 1425 6 F1 Cecr2 CECR2
Rat - 1437 4q42 Cecr2 CECR2
Previous and Unofficial Names
cat eye syndrome chromosome region, candidate 2 | cat eye syndrome chromosome region
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
NVS-1 Hs Inhibition 7.1 – 7.3 pIC50 2
pIC50 7.1 – 7.3 (IC50 8x10-8 – 4.7x10-8 M) [2]
Description: Measured using AlphaScreen or ITC assays.
compound 50 [PMID: 24313754] Hs Inhibition 6.8 pIC50 1
pIC50 6.8 (IC50 1.58x10-7 M) [1]

References

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1. Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I et al.. (2014) [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. J. Med. Chem.57 (2): 462-76. [PMID:24313754]

2. Structural Genomics Consortium. NVS-CECR2-1 A chemical probe for CECR2. Accessed on 11/12/2015. Modified on 11/12/2015. The Structural Genomics Consortium, http://www.thesgc.org/chemical-probes/NVS-1

How to cite this page

Non-enzymatic BRD containing proteins: CECR2, histone acetyl-lysine reader. Last modified on 13/02/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2733.