CD3e

Target id: 2742

Nomenclature: CD3e

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD3e has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 207 11q23 CD3E CD3e molecule
Mouse - 183 9 A5 Cd3e CD3 antigen, epsilon polypeptide
Rat - 188 8q22 Cd3e CD3e molecule
Previous and Unofficial Names
Cde3 | CD3 antigen, epsilon polypeptide | CD3e molecule, epsilon (CD3-TCR complex) | CD3 molecule, epsilon
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
blinatumomab Hs Binding 7.0 pKd 3
pKd 7.0 (Kd 1x10-7 M) [3]
Description: Binding of the single-chain Fv portion of blinatumomab to CD3.
muromonab-CD3 Hs Binding - - 4
[4]
catumaxomab Hs Binding - - 5
[5]
otelixizumab Hs Binding - - 1
[1]
Immunopharmacology Comments
CD3e is part of the CD3/TCR complex that mediates T-cell receptor signal transduction. Defects in this gene cause severe immunodeficiency [2,6].
Immuno Cell Type Associations
Immuno Cell Type:  T cells
Cell Ontology Term:  
Comment: 
References: 
Immuno Process Associations
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
positive regulation of T cell proliferation (GO:0042102) IMP
T cell activation (GO:0042110) NAS
negative thymic T cell selection (GO:0045060) IEA
positive regulation of alpha-beta T cell proliferation (GO:0046641) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell anergy (GO:0002669) IEA
T cell costimulation (GO:0031295) TAS
positive regulation of T cell proliferation (GO:0042102) IMP
positive regulation of alpha-beta T cell proliferation (GO:0046641) IEA
regulation of immune response (GO:0050776) TAS
T cell receptor signaling pathway (GO:0050852) TAS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
positive regulation of T cell proliferation (GO:0042102) IMP
positive regulation of alpha-beta T cell proliferation (GO:0046641) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
positive regulation of T cell proliferation (GO:0042102) IMP
T cell activation (GO:0042110) NAS
negative thymic T cell selection (GO:0045060) IEA
positive regulation of alpha-beta T cell proliferation (GO:0046641) IEA
T cell receptor signaling pathway (GO:0050852) TAS
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T cell anergy (GO:0002669) IEA
negative thymic T cell selection (GO:0045060) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of interferon-gamma production (GO:0032729) IEA
positive regulation of interleukin-4 production (GO:0032753) IEA
positive regulation of interleukin-2 biosynthetic process (GO:0045086) IEA
References: 
Immuno Disease Associations
Disease Name:  Acute lymphocytic leukemia (ALL)
Disease Synonyms:  no synonynms
Comment:  CD3e is the molecular target of approved drug blinatumomab, as a treatment Philadelphia chromosome-negative precursor B-cell ALL
Disease X-refs:  OMIM: 613065
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Immunodeficiency 18; IMD18
Synonyms: CD3epsilon deficiency [Disease Ontology: DOID:0060017]
Immunodeficiency 18, SCID variant [OMIM: 615615]
Immunodeficiency 18, Severe combined immunodeficiency variant [OMIM: 615615]
Severe combined immunodeficiency [Orphanet: ORPHA183660]
T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta [Orphanet: ORPHA169160]
Disease Ontology: DOID:0060017
OMIM: 615615
Orphanet: ORPHA169160, ORPHA183660

References

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1. Bolt S, Routledge E, Lloyd I, Chatenoud L, Pope H, Gorman SD, Clark M, Waldmann H. (1993) The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. Eur. J. Immunol.23 (2): 403-11. [PMID:8436176]

2. de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F. (2004) Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3. J. Clin. Invest.114 (10): 1512-7. [PMID:15546002]

3. Dreier T, Lorenczewski G, Brandl C, Hoffmann P, Syring U, Hanakam F, Kufer P, Riethmuller G, Bargou R, Baeuerle PA. (2002) Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody. Int. J. Cancer100 (6): 690-7. [PMID:12209608]

4. Goldstein G. (1987) Overview of the development of Orthoclone OKT3: monoclonal antibody for therapeutic use in transplantation. Transplant. Proc.19 (2 Suppl 1): 1-6. [PMID:3105134]

5. Linke R, Klein A, Seimetz D. (2010) Catumaxomab: clinical development and future directions. MAbs2 (2): 129-36. [PMID:20190561]

6. Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B. (1993) Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency. Nat. Genet.3 (1): 77-81. [PMID:8490660]

How to cite this page

CD molecules: CD3e. Last modified on 06/02/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2742.