carboxyl ester lipase

Target id: 2872

Nomenclature: carboxyl ester lipase

Family: 3.1.1.- Carboxylic Ester Hydrolases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for carboxyl ester lipase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 756 9q34.3 CEL carboxyl ester lipase
Mouse - 599 2 A3 Cel carboxyl ester lipase
Rat - 612 3p12 Cel carboxyl ester lipase
Previous and Unofficial Names
bile salt-stimulated lipase | bile salt-dependent lipase | BSSL | BSDL | MODY8
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.3
EC Number: 3.1.1.13

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 10f [PMID: 24556381] Pig Inhibition 5.9 pIC50 1
pIC50 5.9 (IC50 1.33x10-6 M) [1]
compound 10l [PMID: 24556381] Pig Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 1.98x10-6 M) [1]

References

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1. Muscia GC, Hautmann S, Buldain GY, Asís SE, Gütschow M. (2014) Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg. Med. Chem. Lett.24 (6): 1545-9. [PMID:24556381]

How to cite this page

3.1.1.- Carboxylic Ester Hydrolases: carboxyl ester lipase. Last modified on 13/08/2015. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2872.