protein phosphatase methylesterase 1 | S33: Prolyl aminopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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protein phosphatase methylesterase 1

Target not currently curated in GtoImmuPdb

Target id: 2875

Nomenclature: protein phosphatase methylesterase 1

Family: 3.1.1.- Carboxylic Ester Hydrolases, S33: Prolyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 400 11q13.4 PPME1 protein phosphatase methylesterase 1
Mouse - 386 7 F! Ppme1 protein phosphatase methylesterase 1
Rat - 386 1q32 Ppme1 protein phosphatase methylesterase 1
Previous and Unofficial Names
PME-1 | PME1
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.89

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ABL127 Hs Inhibition 7.9 pIC50 1
pIC50 7.9 (IC50 1.2x10-8 M) [1]

References

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1. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat. Chem. Biol., 10 (8): 656-63. [PMID:24997602]

How to cite this page

S33: Prolyl aminopeptidase: protein phosphatase methylesterase 1. Last modified on 24/08/2015. Accessed on 23/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2875.