monoacylglycerol O-acyltransferase 2

Target id: 2881

Nomenclature: monoacylglycerol O-acyltransferase 2

Family: 2.3.-.- Acyltransferases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for monoacylglycerol O-acyltransferase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 334 11q13.5 MOGAT2 monoacylglycerol O-acyltransferase 2 3
Mouse 2 334 7 E2 Mogat2 monoacylglycerol O-acyltransferase 2 2
Rat - 334 1q32 Mogat2 monoacylglycerol O-acyltransferase 2
Previous and Unofficial Names
DGAT2L5 | MGAT2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.1.22
Description Reaction Reference
Acyl-CoA + 2-acylglycerol <=> CoA + diacylglycerol 4
Tissue Distribution
Intestine and liver
Species:  Human
Technique:  Northern blot
References:  3
Physiological Consequences of Altering Gene Expression
Mogat2 deficient mice are protected from diet-induced obesity and glucose intolerance.
Species:  Mouse
Tissue: 
Technique:  Gene knockout and inducible Mogat2-inactivating mutation.
References:  1
General Comments
Results from genetic studies in mice [1,5-6] suggest that pharmacoligical inhibition of MOGAT2 may be a useful strategy for controlling metabolic disorders induced by high-fat diet.

References

Show »

1. Banh T, Nelson DW, Gao Y, Huang TN, Yen MI, Yen CL. (2015) Adult-onset deficiency of acyl CoA:monoacylglycerol acyltransferase 2 protects mice from diet-induced obesity and glucose intolerance. J. Lipid Res.56 (2): 379-89. [PMID:25535286]

2. Cao J, Lockwood J, Burn P, Shi Y. (2003) Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J. Biol. Chem.278 (16): 13860-6. [PMID:12576479]

3. Lockwood JF, Cao J, Burn P, Shi Y. (2003) Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity. Am. J. Physiol. Endocrinol. Metab.285 (5): E927-37. [PMID:12824082]

4. Manganaro F, Kuksis A. (1985) Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells. Can. J. Biochem. Cell Biol.63 (5): 341-7. [PMID:4016575]

5. Nelson DW, Gao Y, Spencer NM, Banh T, Yen CL. (2011) Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain. J. Lipid Res.52 (9): 1723-32. [PMID:21734185]

6. Nelson DW, Gao Y, Yen MI, Yen CL. (2014) Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance. J. Biol. Chem.289 (25): 17338-49. [PMID:24784138]

How to cite this page

2.3.-.- Acyltransferases: monoacylglycerol O-acyltransferase 2. Last modified on 18/09/2015. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2881.