monoacylglycerol O-acyltransferase 2

Target id: 2881

Nomenclature: monoacylglycerol O-acyltransferase 2

Family: 2.3.1.- Acyltransferases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for monoacylglycerol O-acyltransferase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 334 11q13.5 MOGAT2 monoacylglycerol O-acyltransferase 2 3
Mouse 2 334 7 E2 Mogat2 monoacylglycerol O-acyltransferase 2 2
Rat - 334 1q32 Mogat2 monoacylglycerol O-acyltransferase 2
Previous and Unofficial Names
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Description Reaction Reference
Acyl-CoA + 2-acylglycerol <=> CoA + diacylglycerol 4
Tissue Distribution
Intestine and liver
Species:  Human
Technique:  Northern blot
References:  3
Physiological Consequences of Altering Gene Expression
Mogat2 deficient mice are protected from diet-induced obesity and glucose intolerance.
Species:  Mouse
Technique:  Gene knockout and inducible Mogat2-inactivating mutation.
References:  1
General Comments
Results from genetic studies in mice [1,5-6] suggest that pharmacoligical inhibition of MOGAT2 may be a useful strategy for controlling metabolic disorders induced by high-fat diet.


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1. Banh T, Nelson DW, Gao Y, Huang TN, Yen MI, Yen CL. (2015) Adult-onset deficiency of acyl CoA:monoacylglycerol acyltransferase 2 protects mice from diet-induced obesity and glucose intolerance. J. Lipid Res., 56 (2): 379-89. [PMID:25535286]

2. Cao J, Lockwood J, Burn P, Shi Y. (2003) Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J. Biol. Chem., 278 (16): 13860-6. [PMID:12576479]

3. Lockwood JF, Cao J, Burn P, Shi Y. (2003) Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity. Am. J. Physiol. Endocrinol. Metab., 285 (5): E927-37. [PMID:12824082]

4. Manganaro F, Kuksis A. (1985) Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells. Can. J. Biochem. Cell Biol., 63 (5): 341-7. [PMID:4016575]

5. Nelson DW, Gao Y, Spencer NM, Banh T, Yen CL. (2011) Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain. J. Lipid Res., 52 (9): 1723-32. [PMID:21734185]

6. Nelson DW, Gao Y, Yen MI, Yen CL. (2014) Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance. J. Biol. Chem., 289 (25): 17338-49. [PMID:24784138]

How to cite this page

2.3.1.- Acyltransferases: monoacylglycerol O-acyltransferase 2. Last modified on 18/09/2015. Accessed on 20/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,