leukocyte immunoglobulin like receptor A4 (CD85g)

Target id: 2896

Nomenclature: leukocyte immunoglobulin like receptor A4 (CD85g)

Abbreviated Name: LILRA4

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     leukocyte immunoglobulin like receptor A4 (CD85g) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 499 19q13.4 LILRA4 leukocyte immunoglobulin like receptor A4
Gene and Protein Information Comments
The LILRA4 protein is translated as a 499 amino acid precursor. The 23 amino terminal residues are a signal peptide, cleaved to form the mature protein. The protein structure has several disulphide bonds, and is heavily glycosylated.
Previous and Unofficial Names
leucocyte Ig-like receptor A4 | ILT7 | immunoglobulin-like transcript 7
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
anti-ILT7 antibody Hs Binding - - 4
[4]
Immunopharmacology Comments
LILRA4 (CD85g) is a member of the activating leukocyte immunoglobulin like receptor (LILRA) family (HGNC family 1181). It is involved in activation of eosinophils and homeostatic regulation of the innate immunity of plasmacytoid dendritic cells (pDCs) [1]. Anti-ILT7 antibody was developed to target CD85g +ve IFNα-producing pDCs as a novel mechanism for the treatment of autoimmune condtions [4].
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
monocyte (CL:0000576)
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   granulocyte (CL:0000094)
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0034156 negative regulation of toll-like receptor 7 signaling pathway IMP
GO:0034164 negative regulation of toll-like receptor 9 signaling pathway IMP
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0034156 negative regulation of toll-like receptor 7 signaling pathway IMP
GO:0034164 negative regulation of toll-like receptor 9 signaling pathway IMP
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0034156 negative regulation of toll-like receptor 7 signaling pathway IMP
GO:0034164 negative regulation of toll-like receptor 9 signaling pathway IMP
GO:0038095 Fc-epsilon receptor signaling pathway IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0032687 negative regulation of interferon-alpha production IMP
GO:0032720 negative regulation of tumor necrosis factor production IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0034156 negative regulation of toll-like receptor 7 signaling pathway IMP
GO:0034164 negative regulation of toll-like receptor 9 signaling pathway IMP
GO:0038095 Fc-epsilon receptor signaling pathway IMP
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Tissue Distribution
Expressed only on plasmacytoid dendritic cells(pDCs)
Species:  Human
Technique:  Polymerase chain reaction (PCR)–based subtraction technique, SAGE library screening, immunocytochemistry
References:  1-3,5
Moderately enriched in lymphoid organs, where pDCs reside.
Species:  Human
Technique:  SAGE library screening
References:  3
Gene Expression and Pathophysiology Comments
LILRA4 (ILT7) is a marker of plasmacytoid dendritic cells (pDCs), cells which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases.
General Comments
LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs) [1]. It interacts with bone marrow stromal cell antigen 2 (BST2; CD317; Q10589) to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms.

References

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1. Cao W, Bover L. (2010) Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol. Rev., 234 (1): 163-76. [PMID:20193018]

2. Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ. (2006) Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J. Exp. Med., 203 (6): 1399-405. [PMID:16735691]

3. Cho M, Ishida K, Chen J, Ohkawa J, Chen W, Namiki S, Kotaki A, Arai N, Arai K, Kamogawa-Schifter Y. (2008) SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production. Int. Immunol., 20 (1): 155-64. [PMID:18048391]

4. Kamogawa Y, Cho M, Arai N, Ishida K. (2011) Anti-ILT7 antibody. Patent number: US8084585 B2. Assignee: Sbi Biotech Co., Ltd.. Priority date: 20/10/2005. Publication date: 27/12/2011.

5. Rissoan MC, Duhen T, Bridon JM, Bendriss-Vermare N, Péronne C, de Saint Vis B, Brière F, Bates EE. (2002) Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood, 100 (9): 3295-303. [PMID:12384430]

How to cite this page

CD molecules: leukocyte immunoglobulin like receptor A4 (CD85g). Last modified on 06/12/2017. Accessed on 20/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2896.