LILRA4 (CD85g)

Target id: 2896

Nomenclature: LILRA4 (CD85g)

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     LILRA4 (CD85g) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 499 19q13.4 LILRA4 leukocyte immunoglobulin like receptor A4
Gene and Protein Information Comments
The LILRA4 protein is translated as a 499 amino acid precursor. The 23 amino terminal residues are a signal peptide, cleaved to form the mature protein. The protein structure has several disulphide bonds, and is heavily glycosylated.
Previous and Unofficial Names
leucocyte Ig-like receptor A4 | ILT7 | immunoglobulin-like transcript 7
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
anti-ILT7 antibody Hs Binding - - 4
[4]
Immunopharmacology Comments
CD85g is involved in activation of eosinophils and homeostatic regulation of the innate immunity of plasmacytoid dendritic cells (pDCs) [1]. Anti-ILT7 antibody was developed to target CD85g +ve IFNα-producing pDCs as a novel mechanism for the treatment of autoimmune condtions [4].
Immuno Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
monocyte (CL:0000576)
Comment: 
References: 
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   granulocyte (CL:0000094)
Comment: 
References: 
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Comment: 
References: 
Immuno Process Associations
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Tissue Distribution
Expressed only on plasmacytoid dendritic cells(pDCs)
Species:  Human
Technique:  Polymerase chain reaction (PCR)–based subtraction technique, SAGE library screening, immunocytochemistry
References:  1-3,5
Moderately enriched in lymphoid organs, where pDCs reside.
Species:  Human
Technique:  SAGE library screening
References:  3
Gene Expression and Pathophysiology Comments
LILRA4 (ILT7) is a marker of plasmacytoid dendritic cells (pDCs), cells which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases.
General Comments
LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs) [1]. It interacts with bone marrow stromal cell antigen 2 (BST2; CD317; Q10589) to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms.

References

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1. Cao W, Bover L. (2010) Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol. Rev.234 (1): 163-76. [PMID:20193018]

2. Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ. (2006) Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J. Exp. Med.203 (6): 1399-405. [PMID:16735691]

3. Cho M, Ishida K, Chen J, Ohkawa J, Chen W, Namiki S, Kotaki A, Arai N, Arai K, Kamogawa-Schifter Y. (2008) SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production. Int. Immunol.20 (1): 155-64. [PMID:18048391]

4. Kamogawa Y, Cho M, Arai N, Ishida K. (2011) Anti-ILT7 antibody. Patent number: US8084585 B2. Assignee: Sbi Biotech Co., Ltd.. Priority date: 20/10/2005. Publication date: 27/12/2011.

5. Rissoan MC, Duhen T, Bridon JM, Bendriss-Vermare N, Péronne C, de Saint Vis B, Brière F, Bates EE. (2002) Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood100 (9): 3295-303. [PMID:12384430]

How to cite this page

CD molecules: LILRA4 (CD85g). Last modified on 15/05/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2896.