αβ-Hydrolase 6

Target id: 2919

Nomenclature: αβ-Hydrolase 6

Abbreviated Name: ABHD6

Family: 2-Acylglycerol ester turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for αβ-Hydrolase 6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ABHD6 abhydrolase domain containing 6
Mouse - - Abhd6 abhydrolase domain containing 6
Rat - - Abhd6 abhydrolase domain containing 6
Previous and Unofficial Names
2-arachidonoylglycerol hydrolase | abhydrolase domain-containing protein 6 | alpha/beta-Hydrolase domain containing 6
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.23
Endogenous substrates
1-arachidonoylglycerol > 2-arachidonoylglycerol > 1-oleoylglycerol > 2-oleoyl glycerol  [3]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
WWL70 Hs Inhibition 7.2 pIC50 2
pIC50 7.2 [2]
WWL123 Hs Inhibition 6.4 pIC50 1
pIC50 6.4 [1]

References

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1. Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF. (2010) Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc. Natl. Acad. Sci. U.S.A.107 (49): 20941-6. [PMID:21084632]

2. Li W, Blankman JL, Cravatt BF. (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J. Am. Chem. Soc.129 (31): 9594-5. [PMID:17629278]

3. Navia-Paldanius D, Savinainen JR, Laitinen JT. (2012) Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J. Lipid Res.53 (11): 2413-24. [PMID:22969151]

How to cite this page

2-Acylglycerol ester turnover: αβ-Hydrolase 6. Last modified on 07/03/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2919.