Zika virus genome polyprotein

Target id: 2953

Nomenclature: Zika virus genome polyprotein

Systematic Nomenclature: Zika virus (strain Mr 766) (ZIKV) polyprotein

Family: Anti-infective targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Zika virus genome polyprotein in GtoImmuPdb

Database Links
UniProtKB
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
NSC157058 N/A - - pIC50 1
pIC50 (IC50 8.2x10-7 M) [1]
General Comments
This polyprotein precursor is proteolytically processed inside the host cell to spawn a number of separate activities (see GO terms in UniProt entry), including enzymes that are important for viral replication. Several of these are being pursued as novel anti-viral drug targets.

References

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1. Shiryaev SA, Farhy C, Pinto A, Huang CT, Simonetti N, Ngono AE, Dewing A, Shresta S, Pinkerton AB, Cieplak P et al.. (2017) Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists. Antiviral Res.143: 218-229. [PMID:28461069]

How to cite this page

Anti-infective targets: Zika virus genome polyprotein. Last modified on 22/08/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2953.