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chitinase 1

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Target not currently curated in GtoImmuPdb

Target id: 3187

Nomenclature: chitinase 1

Family: Chitinases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 466 1q32.1 CHIT1 chitinase 1
Mouse - 464 1 E4 Chit1 chitinase 1
Rat - 464 13q13 Chit1 chitinase 1
Previous and Unofficial Names Click here for help
chitinase 1 (chitotriosidase)
Database Links Click here for help
Alphafold Q13231 (Hs), Q9D7Q1 (Mm)
ChEMBL Target CHEMBL3080 (Hs), CHEMBL4105845 (Mm)
Ensembl Gene ENSG00000133063 (Hs), ENSMUSG00000026450 (Mm), ENSRNOG00000028072 (Rn)
Entrez Gene 1118 (Hs), 71884 (Mm), 289032 (Rn)
Human Protein Atlas ENSG00000133063 (Hs)
KEGG Gene hsa:1118 (Hs), mmu:71884 (Mm), rno:289032 (Rn)
Pharos Q13231 (Hs)
UniProtKB Q13231 (Hs), Q9D7Q1 (Mm)
Wikipedia CHIT1 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound OATD-01 (GLPG4716)
PDB Id:  6ZE8
Ligand:  GLPG4716
Resolution:  1.5Å
Species:  Human
References:  1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GLPG4716 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.6 pIC50 1
⤷ pIC50 7.6 (IC50 2.3x10-8 M) [1]
GLPG4716 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Mm Inhibition 7.6 pIC50 1
⤷ pIC50 7.6 (IC50 2.8x10-8 M) [1]
View species-specific inhibitor tables

References

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1. Koralewski R, Dymek B, Mazur M, Sklepkiewicz P, Olejniczak S, Czestkowski W, Matyszewski K, Andryianau G, Niedziejko P, Kowalski M et al.. (2020) Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem, 63 (24): 15527-15540. [PMID:33078933]

How to cite this page

Chitinases: chitinase 1. Last modified on 16/07/2021. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3187.