5-HT3E | 5-HT<sub>3</sub> receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 377

Nomenclature: 5-HT3E

Family: 5-HT3 receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 - 3q27.1 HTR3E 5-hydroxytryptamine receptor 3E 2-4
Previous and Unofficial Names
HTR3C1long | 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
Tissue Distribution
Colon, intestine.
Species:  Human
Technique:  RT-PCR
References:  3
Small intestine >> spinal cord and retina.
Species:  Human
Technique:  RT-PCR
References:  2
Essentially ubiquitous, relatively high levels of expression in dorsal root ganglia, pituitary, brain, kidney and thyroid
Species:  Human
Technique:  RT-PCR
References:  1
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  Canonical isoform.
Amino acids:  471
Nucleotide accession: 
Protein accession: 
References:  2-3
Type:  Splice variant
Species:  Human
Description:  The human 5-HT3E subunit occurs as a variant that has unofficially been termed 5-HT3E(A) (or HTR3C1short).
Amino acids:  456
Nucleotide accession: 
Protein accession: 
References:  4
General Comments
The 5-HT3E subunit is absent from the rodent genome [1-3]. The human 5-HT3E subunit does not function as a homomer [1,4]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3E subunit at the cell surface in one study [4], but not in a second [1]. Co-assembly of the 5-HT3A and 5-HT3E subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [4]. Co-expression of the 5-HT3A and 5-HT3E subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [1,4].


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1. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP, Courtenay N, Luck J, Rhodes A, Modha S, Moore SE, Sanger GJ, Gunthorpe MJ. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J. Neurochem., 108 (2): 384-96. [PMID:19012743]

2. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW, Roberds SL. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene, 319: 137-48. [PMID:14597179]

3. Niesler B, Frank B, Kapeller J, Rappold GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene, 310: 101-11. [PMID:12801637]

4. Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol. Pharmacol., 72 (1): 8-17. [PMID:17392525]


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How to cite this page

Nicholas M. Barnes, Tim G. Hales, Sarah C. R. Lummis, Beate Niesler, John A. Peters.
5-HT3 receptors: 5-HT3E. Last modified on 14/03/2014. Accessed on 23/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=377.