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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 4 | 474 | 4p12 | GABRB1 | gamma-aminobutyric acid type A receptor subunit beta1 | 2-3 |
| Mouse | 4 | 474 | 5 38.18 cM | Gabrb1 | gamma-aminobutyric acid type A receptor subunit beta 1 | 1 |
| Rat | 4 | 474 | 14p11 | Gabrb1 | gamma-aminobutyric acid type A receptor subunit beta1 | 4 |
| Previous and Unofficial Names |
| gamma-aminobutyric acid receptor subunit beta-1 | Gabrb-1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor beta1 subunit | gamma-aminobutyric acid type A receptor beta 1 subunit |
| Database Links |
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| Alphafold | P18505 (Hs), P50571 (Mm), P15431 (Rn) |
| CATH/Gene3D | 2.70.170.10 |
| ChEMBL Target | CHEMBL4558 (Hs), CHEMBL2094133 (Mm), CHEMBL1907607 (Rn) |
| DrugBank Target | P18505 (Hs), P18505 (Hs) |
| Ensembl Gene | ENSG00000163288 (Hs), ENSMUSG00000029212 (Mm), ENSRNOG00000002327 (Rn) |
| Entrez Gene | 2560 (Hs), 14400 (Mm), 25450 (Rn) |
| Human Protein Atlas | ENSG00000163288 (Hs) |
| KEGG Gene | hsa:2560 (Hs), mmu:14400 (Mm), rno:25450 (Rn) |
| OMIM | 137190 (Hs) |
| Pharos | P18505 (Hs) |
| RefSeq Nucleotide | NM_000812 (Hs), NM_008069 (Mm), NM_012956 (Rn) |
| RefSeq Protein | NP_000803 (Hs), NP_032095 (Mm), NP_037088 (Rn) |
| UniProtKB | P18505 (Hs), P50571 (Mm), P15431 (Rn) |
| Wikipedia | GABRB1 (Hs) |
| Natural/Endogenous Ligands |
| GABA |
Download all structure-activity data for this target as a CSV file 
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Kamatchi GL, Kofuji P, Wang JB, Fernando JC, Liu Z, Mathura JR, Burt DR. (1995) GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim Biophys Acta, 1261 (1): 134-42. [PMID:7893750]
2. Kirkness EF, Kusiak JW, Fleming JT, Menninger J, Gocayne JD, Ward DC, Venter JC. (1991) Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1). Genomics, 10 (4): 985-95. [PMID:1655634]
3. Schofield PR, Pritchett DB, Sontheimer H, Kettenmann H, Seeburg PH. (1989) Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. FEBS Lett, 244 (2): 361-4. [PMID:2465923]
4. Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. (1989) GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J, 8 (6): 1665-70. [PMID:2548852]
