nicotinic acetylcholine receptor α10 subunit | Nicotinic acetylcholine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

nicotinic acetylcholine receptor α10 subunit

Target id: 470

Nomenclature: nicotinic acetylcholine receptor α10 subunit

Family: Nicotinic acetylcholine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for nicotinic acetylcholine receptor α10 subunit in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 450 11p15.5 CHRNA10 cholinergic receptor nicotinic alpha 10 subunit 2
Mouse 4 447 7 E3 Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10
Rat 4 447 1q32 Chrna10 cholinergic receptor nicotinic alpha 10 subunit 1
Previous and Unofficial Names
NACHR alpha 10 | nicotinic acetylcholine receptor subunit alpha 10 | cholinergic receptor, nicotinic, alpha 10 (neuronal) | cholinergic receptor, nicotinic alpha 10 | cholinergic receptor
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
α9α10: PCa/PNa = 9, Pf = 22%
Natural/Endogenous Ligands
acetylcholine
Commonly used antagonists
α9α10: α-bungarotoxin > tropisetron = strychnine > tubocurarine

Download all structure-activity data for this target as a CSV file

Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]methyllycaconitine Hs Antagonist 8.1 pKd
pKd 8.1 (Kd 7.5x10-9 M) α9α10
RgIA4 Rn Antagonist 9.1 pIC50 3
pIC50 9.1 (IC50 9x10-10 M) α9α10 [3]
RgIA4 Hs Antagonist 8.8 pIC50 3
pIC50 8.8 (IC50 1.5x10-9 M) α9α10 [3]
strychnine Hs Antagonist - -
α9α10
nicotine Hs Antagonist - -
α9α10
α-bungarotoxin Hs Antagonist - -
α9α10
muscarine Hs Antagonist - -
α9α10
α-conotoxin RgIA Hs Antagonist - -
α9α10
View species-specific antagonist tables
Tissue Distribution
Pituitary gland, keratinocytes
Species:  Human
Technique:  RT-PCR
References:  4
Pituitary gland (pars tuberalis region), cochlear, vestibular hair cells
Species:  Rat
Technique:  In situ hybridisation, RT-PCR
References:  1,4
Physiological Consequences of Altering Gene Expression
Knockout mice have abnormal innervation, synaptic function and morphology of the cochlear.
Species:  Mouse
Tissue:  in vivo
Technique:  Knockout
References:  5

References

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1. Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J. (2001) alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc. Natl. Acad. Sci. U.S.A., 98 (6): 3501-6. [PMID:11248107]

2. Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA. (2001) Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics, 73 (3): 272-83. [PMID:11350119]

3. Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL et al.. (2017) Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc. Natl. Acad. Sci. U.S.A., 114 (10): E1825-E1832. [PMID:28223528]

4. Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, Bertrand D, Besnard F. (2002) A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol. Pharmacol., 61 (1): 150-9. [PMID:11752216]

5. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J. (2007) The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc. Natl. Acad. Sci. U.S.A., 104 (51): 20594-9. [PMID:18077337]

Contributors

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How to cite this page

Cecilia Gotti, Michael. J. Marks, Neil S. Millar, Susan Wonnacott.
Nicotinic acetylcholine receptors: nicotinic acetylcholine receptor α10 subunit. Last modified on 27/02/2017. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=470.