Target id: 482

Nomenclature: P2X5

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for P2X5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 422 17p13.3 P2RX5 purinergic receptor P2X 5 8
Mouse 2 455 11 B5 P2rx5 purinergic receptor P2X 5
Rat 2 455 10q24 P2rx5 purinergic receptor P2X 5 4
Gene and Protein Information Comments
Seventy-five P2X5 genes have been identified in the genomes of 75 placental mammalian species (Eutheria) [9].
Previous and Unofficial Names
P2X purinoceptor 5 | purinergic receptor P2X, ligand gated ion channel, 5
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
Comments: Endogenous agonist: ATP at human [3] and mouse [5] P2X5 receptors.

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ATP Rn Agonist 6.0 pEC50 6
pEC50 6.0 (EC50 1x10-6 M) [6]
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
suramin Rn Antagonist 5.4 pIC50 6
pIC50 5.4 (IC50 4x10-6 M) [6]
Physiological Consequences of Altering Gene Expression
Altered inflammatory response in murine osteoclasts, with reduced bone loss.
Species:  Mouse
Tissue:  Osteoclasts
Technique:  Gene knockout
References:  7
General Comments
The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa).

Of all the functional P2X receptors, only P2X5 homopolymer is unregulated by intracellular PIPn [1-2].


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1. Ase AR, Bernier LP, Blais D, Pankratov Y, Séguéla P. (2010) Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit. J. Neurochem.113 (6): 1676-84. [PMID:20374427]

2. Bernier LP, Ase AR, Séguéla P. (2013) Post-translational regulation of P2X receptor channels: modulation by phospholipids. Front Cell Neurosci7: 226. [PMID:24324400]

3. Bo X, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA. (2003) Pharmacological and biophysical properties of the human P2X5 receptor. Mol. Pharmacol.63 (6): 1407-16. [PMID:12761352]

4. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci.16 (8): 2495-507. [PMID:8786426]

5. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene270 (1-2): 145-52. [PMID:11404011]

6. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem.45 (19): 4057-93. [PMID:12213051]

7. Kim H, Walsh MC, Takegahara N, Middleton SA, Shin HI, Kim J, Choi Y. (2017) The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts. Sci Rep7 (1): 196. [PMID:28298636]

8. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett.418 (1-2): 195-9. [PMID:9414125]

9. Zdobnov EM, Tegenfeldt F, Kuznetsov D, Waterhouse RM, Simão FA, Ioannidis P, Seppey M, Loetscher A, Kriventseva EV. (2017) OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs. Nucleic Acids Res.45 (D1): D744-D749. [PMID:27899580]


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How to cite this page

Francesco Di Virgilio, Richard J Evans, Simonetta Falzoni, Michael F Jarvis, Charles Kennedy, Brian King, John A. Peters, Baljit S. Khakh, Patrizia Pellegatti.
P2X receptors: P2X5. Last modified on 24/11/2017. Accessed on 21/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=482.