P2X5

Target id: 482

Nomenclature: P2X5

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for P2X5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 422 17p13.3 P2RX5 purinergic receptor P2X 5 4
Mouse 2 455 11 B5 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 2
Rat 2 455 10q24 P2rx5 purinergic receptor P2X 5 1
Previous and Unofficial Names
P2X purinoceptor 5 | purinergic receptor P2X, ligand gated ion channel, 5
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
ATP

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ATP Rn Agonist 6.0 pEC50 3
pEC50 6.0 (EC50 1x10-6 M) [3]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
suramin Rn Antagonist 5.4 pIC50 3
pIC50 5.4 (IC50 4x10-6 M) [3]
General Comments
The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa).

References

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1. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci.16 (8): 2495-507. [PMID:8786426]

2. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene270 (1-2): 145-52. [PMID:11404011]

3. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem.45 (19): 4057-93. [PMID:12213051]

4. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett.418 (1-2): 195-9. [PMID:9414125]

Contributors

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How to cite this page

Francesco Di Virgilio, Richard J Evans, Simonetta Falzoni, Michael F Jarvis, Charles Kennedy, Brian King, John A. Peters, Baljit S. Khakh, Patrizia Pellegatti.
P2X receptors: P2X5. Last modified on 20/04/2017. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=482.