TRPP3 | Transient Receptor Potential channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 506

Nomenclature: TRPP3

Family: Transient Receptor Potential channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 613 5q31 PKD2L2 polycystin 2 like 2, transient receptor potential cation channel 3
Mouse 6 1 621 18 C Pkd2l2 polycystic kidney disease 2-like 2 1
Rat 6 1 621 18p12 Pkd2l2 polycystin 2 like 2
Previous and Unofficial Names
TRPP5 | polycystin 2 like 2 | polycystin 2 like 2, transient receptor potential cation channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
Species:  Human
Technique:  Northern Blot
References:  3
Widely expressed in fetal tissues (tissue-specific expression of splice variants).
Species:  Human
Technique:  RT-PCR
References:  1
Testis, heart
Species:  Mouse
Technique:  Northern Blot
References:  1
Functional Assays
Patch clamp (inside-out configuration)
Species:  Human
Tissue:  HEK 293 overexpressing TRPP3
Response measured:  Single channel current. This has not, however, been definitively identified as due to TRPP3.
References:  2
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Pkd2l2tm1Dgen Pkd2l2tm1Dgen/Pkd2l2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:1858231  MP:0001399 hyperactivity
General Comments
No known association with human polycystic kidney disease.


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1. Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, Zhou J. (2000) Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics, 64 (3): 241-51. [PMID:10756092]

2. Sutton KA, Jungnickel MK, Ward CJ, Harris PC, Florman HM. (2006) Functional characterization of PKDREJ, a male germ cell-restricted polycystin. J. Cell. Physiol., 209 (2): 493-500. [PMID:16883570]

3. Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ. (1999) Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). Eur. J. Hum. Genet., 7 (8): 860-72. [PMID:10602361]


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How to cite this page

David E. Clapham, Bernd Nilius, Grzegorz Owsianik.
Transient Receptor Potential channels: TRPP3. Last modified on 18/08/2014. Accessed on 20/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY,