CCR10 | Chemokine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

CCR10

Target id: 67

Nomenclature: CCR10

Family: Chemokine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     CCR10 has curated GtoImmuPdb data

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 362 17q21.1-q21.3 CCR10 C-C motif chemokine receptor 10 2-3,7,9,13
Mouse 7 362 11 D Ccr10 chemokine (C-C motif) receptor 10 7,12-13
Rat 7 - 10q32.1 Ccr10 C-C motif chemokine receptor 10
Previous and Unofficial Names
GPR-2 [4,13]
Database Links
Specialist databases
GPCRDB ccr10_human (Hs), ccr10_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
CCL27 {Sp: Human}
CCL28 {Sp: Human}
CCL27 {Sp: Mouse}
CCL28 {Sp: Mouse}

Download all structure-activity data for this target as a CSV file

Agonist Comments
It has been shown that CCL27 (CTACK/ALP/ILC) [5] and CCL28 (MEC) [13] are both ligands for the CCR10 receptor.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
BI-6901 Hs Antagonist 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
BI-6901 Mm Antagonist 7.6 pIC50 1
pIC50 7.6 (IC50 2.5x10-8 M) [1]
View species-specific antagonist tables
Immunopharmacology Comments
CCR10 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0016493 C-C chemokine receptor activity IEA
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Calcium channel
References: 
Tissue Distribution
Glomerular podocytes.
Species:  Human
Technique:  RT-PCR.
References:  6
Heart > lung, small intestine, colon > skeletal muscle.
Species:  Human
Technique:  Northern blotting.
References:  12
T lymphocytes.
Species:  Human
Technique:  Flow cytometry.
References:  4-5,11
Skin: melanocytes, dermal fibroblasts and dermal microvascular endothelial cells.
Species:  Human
Technique:  Immunohistochemistry.
References:  4-5
Fetal: ovary, unterus, adipose tissue, small intestine, gall bladder, heart, lung, kidney.
Adult: colon, splenocytes, peripheral blood mononuclear cells.
Species:  Human
Technique:  Real-time qPCR.
References:  13
Colon, lymph nodes, Peyer's Patches, lung, spleen, testes, thymus, B cell, T cells.
Species:  Mouse
Technique:  Real-time qPCR.
References:  13
Stomach, lung, small intestine, brain, bone marrow, liver, colon, ovary, adrenal gland, spinal cord, kidney, axial lymph node, testis, heart, skin, spleen, thymus.
Species:  Mouse
Technique:  RT-PCR.
References:  12
Lung, heart > spleen, skeletal muscle.
Species:  Mouse
Technique:  Northern blotting.
References:  12
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of chemotaxis of the murine pre-B lymphoma cell line, L1.2, transfected with the human CCR10 receptor.
Species:  Human
Tissue:  L1.2 cells.
Response measured:  Chemotaxis.
References:  7-8,11
Measurement of Ca2+ levels in the murine pre-B lymphoma cell line, L1.2, transfected with the human CCR10 receptor.
Species:  Human
Tissue:  L1.2 cells.
Response measured:  Ca2+ mobilisation.
References:  7-8
Measurement of chemotaxis in BAF/3 cells transfected with the human CCR10 receptor.
Species:  Human
Tissue:  BAF/3 cells.
Response measured:  Chemotaxis.
References:  5
Measurement of Ca2+ levels in BAF/3 cells transfected with the human CCR10 receptor.
Species:  Human
Tissue:  BAF/3 cells.
Response measured:  Ca2+ mobilisation.
References:  5,13
Measurement of tumour formation in mouse ear skin injected with B16 melanoma cells transfected with the mouse CCR10 receptor.
Species:  Mouse
Tissue:  Ear skin injected with CCR10-transfected B16 cells.
Response measured:  Tumour formation.
References:  10
Measurement of Ca2+ levels in BAF/3 cells transfected with the mouse CCR10 receptor
Species:  Mouse
Tissue:  BAF/3 cells.
Response measured:  Ca2+ mobilisation.
References:  13
Physiological Functions
T lymphocyte recruitment to the skin.
Species:  Human
Tissue:  In vivo.
References:  4
Tumour progression.
Species:  Mouse
Tissue:  Ear skin.
References:  10
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0005402 abnormal action potential PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0005404 abnormal axon morphology PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000889 abnormal cerebellar molecular layer PMID: 17549747 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001431 abnormal eating behavior PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001406 abnormal gait PMID: 11395000  16551741 
Ccr10tm1Cge Ccr10tm1Cge/Ccr10tm1Cge
C.129S4-Ccr10
MGI:1096320  MP:0003156 abnormal leukocyte migration PMID: 18941222 
Ccr10tm1Cge Ccr10tm1Cge/Ccr10tm1Cge
C.129S4-Ccr10
MGI:1096320  MP:0004047 abnormal milk composition PMID: 18941222 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0003871 abnormal myelin sheath morphology PMID: 11395000  17549747 
Ccr10tm1Cge Ccr10tm1Cge/Ccr10tm1Cge
C.129S4-Ccr10
MGI:1096320  MP:0002439 abnormal plasma cell morphology PMID: 18941222 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000877 abnormal Purkinje cell morphology PMID: 16551741  17549747 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0003491 abnormal voluntary movement PMID: 16551741 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001393 ataxia PMID: 11395000  16551741 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001265 decreased body size PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001262 decreased body weight PMID: 11395000 
Ccr10tm1.1Nax Ccr10tm1.1Nax/Ccr10tm1.1Nax
B6.129S4-Ccr10
MGI:1096320  MP:0008351 decreased gamma-delta intraepithelial T cell number PMID: 20937851 
Ccr10tm1Cge Ccr10tm1Cge/Ccr10tm1Cge
C.129S4-Ccr10
MGI:1096320  MP:0001807 decreased IgA level PMID: 18941222 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0010050 hypermyelination PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001402 hypoactivity PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001525 impaired balance PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0001405 impaired coordination PMID: 16551741 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000160 kyphosis PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0008569 lethality at weaning PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000743 muscle spasm PMID: 11395000 
Ccr10tm1Cge Ccr10tm1Cge/Ccr10tm1Cge
Not Specified
MGI:1096320  MP:0002169 no abnormal phenotype detected PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000754 paresis PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0002083 premature death PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0008814 reduced nerve conduction velocity PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000745 tremors PMID: 11395000 
Ccr10/Cntnap1tm1Bhat Ccr10/Cntnap1tm1Bhat/Ccr10/Cntnap1tm1Bhat
involves: 129S7/SvEvBrd
MGI:1096320  MP:0000746 weakness PMID: 11395000 

References

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1. Abeywardane A, Caviness G, Choi Y, Cogan D, Gao A, Goldberg D, Heim-Riether A, Jeanfavre D, Klein E, Kowalski JA et al.. (2016) N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg. Med. Chem. Lett., 26 (21): 5277-5283. [PMID:27692854]

2. Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF. (1997) Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol., 16: 1249-1256. [PMID:9364936]

3. Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ. (2000) Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol, 164: 2851-2856. [PMID:10706668]

4. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A. (2002) CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med, 8: 157-165. [PMID:11821900]

5. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Muller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A. (2000) Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol., 164: 3465-3470. [PMID:10725697]

6. Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H. (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol, 168: 6244-6252. [PMID:12055238]

7. Jarmin DI, Rits M, Bota D, Gerard NP, Graham GJ, Clark-Lewis I, Gerard C. (2000) Cutting edge: Identification of the orphan receptor G protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. J. Immunol., 164: 3460-3464. [PMID:10725696]

8. Lüttichau HR, Lewis IC, Gerstoft J, Schwartz TW. (2001) The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor. Eur J Immunol, 31: 1217-1220. [PMID:11298347]

9. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF. (1994) Cloning of human genes encoding novel G protein-coupled receptors. Genomics, 23: 609-618. [PMID:7851889]

10. Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST. (2003) Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J Exp Med, 198: 1337-1347. [PMID:14581607]

11. Soler D, Humphreys TL, Spinola SM, Campbell JJ. (2003) CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood, 101: 1677-1682. [PMID:12406880]

12. Townson JR, Nibbs RJ. (2002) Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. Eur J Immunol, 32: 1230-1241. [PMID:11981810]

13. Wang W, Soto H, Oldham ER, Buchanan ME, Homey B, Catron D, Jenkins N, Copeland NG, Gilbert DJ, Nguyen N, Abrams J, Kershenovich D, Smith K, McClanahan T, Vicari AP, Zlotnik A. (2000) Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem, 275: 22313-22323. [PMID:10781587]

Contributors

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How to cite this page

Israel F. Charo, Rebecca Hills, Richard Horuk, Kouji Matsushima, Philip M. Murphy, Joost J. Oppenheim.
Chemokine receptors: CCR10. Last modified on 19/02/2018. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=67.