RyR2 | Ryanodine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

RyR2

Target id: 748

Nomenclature: RyR2

Family: Ryanodine receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for RyR2 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 0 - 1q43 RYR2 ryanodine receptor 2
Mouse - 0 - 13 A1-A2 Ryr2 ryanodine receptor 2, cardiac
Rat - 0 - 17q12.1 Ryr2 ryanodine receptor 2
Previous and Unofficial Names
ARVD2 | cardiac muscle ryanodine receptor | cardiac muscle ryanodine receptor-calcium release channel | ryanodine receptor 2 | ryanodine receptor 2, cardiac | RYR-2 | arrhythmogenic right ventricular dysplasia 2 | VTSIP | ryanodine receptor 2 (cardiac)
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Functional Characteristics
Ca2+: (P Ca/P K6) single-channel conductance: 90 pS (50mM Ca2+), 720 pS (210 mM K+)

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
caffeine Hs - - - - -
pharmacological; mM range
cytosolic Ca2+ Hs - - - - -
endogenous; μM range
luminal Ca2+ Hs - - - - -
endogenous
cytosolic ATP Hs - - - - -
endogenous; mM range
suramin Hs - - - - -
pharmacological; μM range
ryanodine Hs - - - - -
pharmacological; nM - μM range
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cytosolic Ca2+ Hs Antagonist - -
Conc range: > 1x10-3 M
cytosolic Mg2+ Hs Antagonist - -
mM range
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
ryanodine Hs - - - > 1x10-4 -
Conc range: > 1x10-4 M
ruthenium red Hs - - - - -
procaine Hs - - - - -

How to cite this page

Ryanodine receptors: RyR2. Last modified on 28/07/2017. Accessed on 13/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=748.