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P1B P-type ATPases: Cu+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Copper-transporting ATPases convey copper ions across cell-surface and intracellular membranes. They consist of eight TM domains and associate with multiple copper chaperone proteins (e.g. ATOX1, O00244).

Transporters

852
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ATP7A Show summary »

Target Id 852
Nomenclature ATP7A
Previous and unofficial names ATPase | ATPase, Cu2+ transporting, alpha polypeptide | ATPase Cu++ transporting alpha polypeptide (Menkes syndrome) | copper pump 1 | Copper-transporting ATPase 1 | Menkes disease-associated protein
Genes ATP7A (Hs), Atp7a (Mm), Atp7a (Rn)
Ensembl ID ENSG00000165240 (Hs), ENSMUSG00000033792 (Mm), ENSRNOG00000061367 (Rn)
UniProtKB AC Q04656 (Hs), Q64430 (Mm), P70705 (Rn)
EC number
3.6.3.4
Comment In January 2026 the US FDA approved copper histidinate (Zycubo®) as a subcutaneous injectable copper replacement therapy for the treatment of Menkes disease caused by mutations in ATP7A.

ATP7B Show summary »

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.