<i>GPR22</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR22

Target id: 93

Nomenclature: GPR22

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR22 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 433 7q22-q31.1 GPR22 G protein-coupled receptor 22 5
Mouse 7 432 12 A3 Gpr22 G protein-coupled receptor 22
Rat 7 - 6q16 Gpr22 G protein-coupled receptor 22
Database Links
Specialist databases
GPCRDB gpr22_human (Hs), gpr22_mouse (Mm), d4a3u0_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  1
Tissue Distribution
Frontal cortex, caudate, putamen, thalamus
Species:  Human
Technique:  Northern blot
References:  5
Brain (cerebellum, cerebral cortex, amygdala), heart
Species:  Human
Technique:  Microarray analysis, Affymetrix GeneChip platform
References:  4
Brain (accumbens, amygdala, cerebellum, cortex, hippocampus), heart (myocardial enrichment)
Species:  Human
Technique:  Northern blot, RT-PCR
References:  1
Brain, heart
Species:  Mouse
Technique:  Northern blot, In situ hybridisation
References:  1
Articular cartilage of knee
Species:  Mouse
Technique:  Immunohistochemistry
References:  3
Brain, heart (cardiomyocytes, coronary arteries)
Species:  Rat
Technique:  Northern blot, Immunohistochemistry
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Functions Comments
Myocardial mRNA expression reduced following aortic banding suggesting a protective role in the hemodynamic stress response associated with increased afterload [1].
Physiological Consequences of Altering Gene Expression
Increased succeptibility to functional decompensation following aortic banding
Species:  Mouse
Tissue:  Heart
Technique:  Gene knockout
References:  1
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr22tm1.1Jwad Gpr22tm1.1Jwad/Gpr22tm1.1Jwad
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
MGI:1920260  MP:0004485 increased response of heart to induced stress PMID: 18539757 
Gpr22tm1Jwad Gpr22tm1Jwad/Gpr22tm1Jwad
involves: 129/Sv * C57BL/6 * SJL
MGI:1920260  MP:0002169 no abnormal phenotype detected PMID: 18539757 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Osteoarthritis
Disease Ontology: DOID:8398
Role: 
References:  2-3,6

References

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1. Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. (2008) Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am. J. Physiol. Heart Circ. Physiol., 295 (2): H509-21. [PMID:18539757]

2. Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD et al.. (2011) Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann. Rheum. Dis., 70 (2): 349-55. [PMID:21068099]

3. Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkársdóttir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB. (2010) A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum., 62 (2): 499-510. [PMID:20112360]

4. Lee J, Hever A, Willhite D, Zlotnik A, Hevezi P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J, 19: 1356-1358. [PMID:15955843]

5. O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR. (1997) Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. Gene, 187 (1): 75-81. [PMID:9073069]

6. Valdes AM, Spector TD. (2010) The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol, 22 (2): 139-43. [PMID:20090528]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR22. Last modified on 15/08/2014. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=93.