<i>GPR25</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR25

Target id: 95

Nomenclature: GPR25

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR25 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 361 1q32.1 GPR25 G protein-coupled receptor 25 1
Mouse 7 367 1 E4 Gpr25 G protein-coupled receptor 25
Rat 7 345 13q13 Gpr25 G protein-coupled receptor 25
Database Links
Specialist databases
GPCRDB gpr25_human (Hs), gpr25_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution Comments
Northern blot analysis of poly(A)+ mRNA extracted from human tissues revealed no expression of GPR25 in liver and brain regions examined (basal forebrain, frontal cortex, thalamus, hypothalamus, amygdala, caudate, putamen, hippocampus, midbrain, medulla, cerebellum and pituitary) [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S360C
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S159L
Global MAF (%):  1
Subpopulation MAF (%):  AFR|AMR|EUR: 1|1|1
Minor allele count:  T=0.008/18
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency

References

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1. Jung BP, Nguyen T, Kolakowski LF, Lynch KR, Heng HH, George SR, O'Dowd BF. (1997) Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1. Biochem. Biophys. Res. Commun., 230 (1): 69-72. [PMID:9020062]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR25. Last modified on 26/06/2015. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=95.