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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 177 | |
Name: | Cardiac arrhythmia | |
Associated with: | 2 targets |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖Kir3.4 | |
Role: | Supraventricular tachycardias caused by re-entrant circuits. |
Drugs: | Adenosine (activation of Kir3.1/3.4 via purinergic receptors). |
Side effects: | Flushing, rapid heart rate, nausea. |
Therapeutic use: | To restore normal sinus rhythm. |
References: | 1 |
Cav1.2 | |
Drugs: | Verapamil, methoxyverapamil, diltiazem |
References: | 2-3 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Cardiac arrhythmia
1. Armstrong A, Clapham DE. (2007) Pharmacology of Cardiac Rhythm. In Principles of pharmacology: the pathophysiologic basis of drug therapy (2nd edition). Edited by Dolan DE, Tashjian AH, Armstrong EJ, Armstrong AW (Lipponcott Williams and Wilkins) 307-324. [ISBN:0781783550]
2. Patten M, Maas R, Bauer P, Lüderitz B, Sonntag F, Dluzniewski M, Hatala R, Opolski G, Müller HW, Meinertz T et al.. (2004) Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial. Eur Heart J, 25 (16): 1395-404. [PMID:15321697]
3. Poole-Wilson PA, Lubsen J, Kirwan BA, van Dalen FJ, Wagener G, Danchin N, Just H, Fox KA, Pocock SJ, Clayton TC et al.. (2004) Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial. Lancet, 364 (9437): 849-57. [PMID:15351192]