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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 673 | |
Name: | Nephrogenic syndrome of inappropriate antidiuresis | |
Associated with: | 1 target |
Synonyms |
Inappropriate antidiuretic hormone secretion syndrome |
Database Links |
OMIM:
300539 Orphanet: ORPHA83449 |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖V2 receptor | |
Comments: | Activating mutations have been identified in the AVPR2 gene resulting in a syndrome termed "nephrogenic syndrome of inappropriate antidiuresis" (NSIAD), a common cause of familial hyponatremia. |
References: | 1-3 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Nephrogenic syndrome of inappropriate antidiuresis
1. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL et al.. (2005) Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med, 352 (18): 1884-90. [PMID:15872203]
2. Gitelman SE, Feldman BJ, Rosenthal SM. (2006) Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. Am J Med, 119: S54-S58. [PMID:16843086]
3. Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE. (2006) Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatr Endocrinol Rev, 4 Suppl 1: 66-70. [PMID:17261972]