V<sub>2</sub> receptor | Vasopressin and oxytocin receptors | IUPHAR/BPS Guide to PHARMACOLOGY

V2 receptor

Target id: 368

Nomenclature: V2 receptor

Family: Vasopressin and oxytocin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for V2 receptor in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 371 Xq28 AVPR2 arginine vasopressin receptor 2 8,69
Mouse 7 371 X A7.3 Avpr2 arginine vasopressin receptor 2 52
Rat 7 371 Xq37 Avpr2 arginine vasopressin receptor 2 44
Previous and Unofficial Names
ADHR | DIR3 | antidiuretic hormone receptor | renal-type arginine vasopressin receptor
Database Links
Specialist databases
GPCRDB v2r_human (Hs), v2r_mouse (Mm), v2r_rat (Rn)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
oxytocin {Sp: Human, Mouse, Rat}
vasopressin {Sp: Human, Mouse, Rat}
Comments: Vasopressin is the principal endogenous agonist
Potency order of endogenous ligands (Human)
vasopressin (AVP, P01185) > oxytocin (OXT, P01178)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]AVP (human, mouse, rat) Hs Full agonist 8.4 – 9.4 pKd 13,16-17,48,64,75-76,80-81,86
pKd 8.4 – 9.4 (Kd 3.98x10-9 – 3.99x10-10 M) [13,16-17,48,64,75-76,80-81,86]
[3H]AVP (human, mouse, rat) Rn Full agonist 8.8 pKd 17
pKd 8.8 [17]
[3H]dDAVP Hs Full agonist 7.2 – 9.1 pKd 13,17,80
pKd 7.2 – 9.1 (Kd 6.3x10-8 – 8x10-10 M) [13,17,80]
[3H]OT (human, mouse, rat) Hs Full agonist 5.8 pKd
pKd 5.8
dVDAVP Hs Full agonist 8.6 – 9.1 pKi 21,80
pKi 8.6 – 9.1 [21,80]
desmopressin Rn Full agonist 8.7 pKi 17
pKi 8.7 [17]
vasopressin {Sp: Human, Mouse, Rat} Hs Full agonist 7.9 – 9.1 pKi 1,11,13,21,48,64,71,75-76,80,86
pKi 7.9 – 9.1 [1,11,13,21,48,64,71,75-76,80,86]
[Val4]AVP Hs Full agonist 8.4 pKi 21
pKi 8.4 [21]
DAVP Rn Full agonist 8.3 pKi 17
pKi 8.3 [17]
dAVP Hs Full agonist 8.3 pKi 11,21
pKi 8.3 [11,21]
desmopressin Hs Full agonist 7.2 – 8.6 pKi 11,13,17,48,64,71,75,80
pKi 7.2 – 8.6 (Ki 6.3x10-8 – 2.5x10-9 M) [11,13,17,48,64,71,75,80]
arginine vasotocin Hs Full agonist 7.6 – 8.2 pKi 13,80
pKi 7.6 – 8.2 [13,80]
LVP {Sp: Pig} Hs Full agonist 7.0 – 8.5 pKi 71,80
pKi 7.0 – 8.5 [71,80]
DAVP Hs Full agonist 7.3 – 7.6 pKi 13,17
pKi 7.3 – 7.6 [13,17]
[Phe3]OT Hs Full agonist 7.1 pKi 13
pKi 7.1 [13]
OPC-51803 Hs Full agonist 7.0 pKi 48
pKi 7.0 [48]
d[Leu4]LVP Rn Full agonist 7.0 pKi 58
pKi 7.0 [58]
d[D-Phe2]AVP Hs Full agonist 6.6 pKi 21
pKi 6.6 [21]
d[Leu4,Dap8]VP Rn Full agonist 6.6 pKi 58
pKi 6.6 [58]
d[Leu4]AVP Hs Full agonist 6.6 pKi 11
pKi 6.6 [11]
d[Cha4]AVP Hs Full agonist 6.5 pKi 21
pKi 6.5 [21]
d[Cha4,Dab8]VP Rn Full agonist 6.3 pKi 58
pKi 6.3 [58]
d[Cha4]LVP Rn Full agonist 6.2 pKi 58
pKi 6.2 [58]
oxytocin {Sp: Human, Mouse, Rat} Hs Full agonist 5.4 – 6.8 pKi 13,15,64,75-76,80
pKi 5.4 – 6.8 [13,15,64,75-76,80]
d[D-Pal2]AVP Hs Agonist 5.0 – 5.2 pKi 21,66,80
pKi 5.0 – 5.2 (Ki 9.6x10-6 – 6.422x10-6 M) [21,66,80]
VNA932 Hs Full agonist 7.1 pIC50 24
pIC50 7.1 (IC50 8x10-8 M) [24]
View species-specific agonist tables
Agonist Comments
The binding affinities at the V2 receptor found in study [58] are from native tissues.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]d(CH2)5[D-Ile2,Ile4,Tyr-NH29]AVP Rn Antagonist 9.5 pKd 17
pKd 9.5 [17]
[125I]d(CH2)5[D-Tyr(Et)2,Val4,Tyr-NH29]AVP Rn Antagonist 9.4 pKd 17
pKd 9.4 [17]
[125I]d(CH2)5[D-Tyr(Et)2,Ile4,Tyr-NH29]AVP Rn Antagonist 9.3 pKd 17
pKd 9.3 [17]
[125I]d(CH2)5[D-Ile2,Val4,Tyr-NH29]AVP Rn Antagonist 9.2 pKd 17
pKd 9.2 [17]
[125I]d(CH2)5[D-Tyr(Et)2,Ile4,Tyr-NH29]AVP Hs Antagonist 9.1 pKd 17
pKd 9.1 [17]
[125I]d(CH2)5[D-Tyr(Et)2,Val4,Tyr-NH29]AVP Hs Antagonist 9.1 pKd 17
pKd 9.1 [17]
[3H]SR 121463A Hs Inverse agonist 8.4 – 9.3 pKd 17,70
pKd 8.4 – 9.3 (Kd 4.1x10-9 – 5x10-10 M) [17,70]
conivaptan Hs Antagonist 9.4 pKi 19
pKi 9.4 (Ki 3.6x10-10 M) [19]
tolvaptan Hs Antagonist 9.4 – 9.4 pKi 86
pKi 9.4 [86]
pKi 9.4 (Ki 4.3x10-10 M) [86]
satavaptan Rn Antagonist 9.3 pKi 17
pKi 9.3 [17]
d(CH2)5[D-Tyr(Et)2,Val4,Tyr-NH29]AVP Hs Antagonist 9.1 pKi 16
pKi 9.1 [16]
lixivaptan Hs Inverse agonist 8.9 – 9.2 pKi 4,71
pKi 8.9 – 9.2 [4,71]
RWJ-351647 Hs Antagonist 9.0 pKi 32
pKi 9.0 [32]
YM 471 Hs Antagonist 8.9 pKi 81
pKi 8.9 [81]
tolvaptan Rn Antagonist 8.9 pKi 86
pKi 8.9 [86]
SKF-105494 Hs Antagonist 8.9 pKi 71
pKi 8.9 [71]
satavaptan Hs Antagonist 8.4 – 9.3 pKi 1,16-17,70-71,75,81
pKi 8.4 – 9.3 [1,16-17,70-71,75,81]
d(CH2)5[D-Ile2,Val4,Tyr-NH29]AVP Rn Antagonist 8.6 pKi 17
pKi 8.6 [17]
d(CH2)5[D-Ile2,Ile4,Tyr-NH29]AVP Rn Antagonist 8.4 pKi 17
pKi 8.4 [17]
d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP Hs Antagonist 8.0 – 8.3 pKi 71,75
pKi 8.0 – 8.3 [71,75]
mozavaptan Rn Inverse agonist 7.4 – 8.2 pKi 17,86
pKi 7.4 – 8.2 [17,86]
mozavaptan Hs Inverse agonist 7.4 – 8.1 pKi 17,71,75,80,86-87
pKi 7.4 – 8.1 [17,71,75,80,86-87]
d(CH2)5[D-Ile2,Ile4]AVP Hs Antagonist 6.9 – 8.4 pKi 71
pKi 6.9 – 8.4 [71]
d(CH2)5[D-Ile2,Ile4,Ala-NH29]AVP Hs Antagonist 7.1 – 7.7 pKi 71,80
pKi 7.1 – 7.7 [71,80]
[tBaa1,D-Tyr(Et)2,Val4,Lys6,Arg-NH28,des-Gly9]AVP Hs Antagonist 7.3 pKi 80
pKi 7.3 [80]
d(CH2)5[D-Ile2,Val4,Tyr-NH29]AVP Hs Antagonist 7.3 pKi 17
pKi 7.3 [17]
d(CH2)5[D-Ile2,Ile4,Ala-NH2]AVP Hs Antagonist 7.1 pKi 80
pKi 7.1 [80]
d(CH2)5[D-Ile2,Ile4,Tyr-NH29]AVP Hs Antagonist 6.9 pKi 17
pKi 6.9 [17]
d(CH2)5[Tyr(Me)2]AVP Hs Antagonist 6.7 – 7.1 pKi 16,64,71,75-76,80
pKi 6.7 – 7.1 [16,64,71,75-76,80]
relcovaptan Hs Antagonist 6.6 – 6.9 pKi 16,71,75,80-81
pKi 6.6 – 6.9 [16,71,75,80-81]
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Hs Antagonist 6.7 pKi 9
pKi 6.7 [9]
[Phaa1,D-Tyr2,Val4,Arg6,Arg-NH29]AVP Hs Antagonist 6.6 pKi 80
pKi 6.6 [80]
[Phaa1,D-Tyr(Et)2,Lys6,des-Gly9]AVP Hs Antagonist 6.5 – 6.6 pKi 71,80
pKi 6.5 – 6.6 [71,80]
d[Pen1,Tyr(Me)2]AVP Hs Antagonist 6.4 – 6.7 pKi 71,75
pKi 6.4 – 6.7 [71,75]
[Phaa1,D-Tyr(Me)2,Arg6,Tyr-NH29]AVP Hs Antagonist 6.5 pKi 80
pKi 6.5 [80]
OH-LVA Hs Antagonist 6.4 pKi 80
pKi 6.4 [80]
YM 218 Hs Antagonist 6.4 pKi 77
pKi 6.4 [77]
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Hs Antagonist 6.0 pKi 71,80
pKi 6.0 [71,80]
nelivaptan Hs Antagonist 5.9 pKi 73
pKi 5.9 [73]
atosiban Hs Antagonist 5.5 – 6.0 pKi 15,72
pKi 5.5 – 6.0 [15,72]
[Phaa1,D-Tyr(Et)2,Val4,Lys6,Tyr-NH28,des-Gly9]AVP Hs Antagonist 5.7 pKi 80
pKi 5.7 [80]
d(CH2)5[Tyr(Me)2,Thr4]OVT Hs Antagonist 5.2 pKi 80
pKi 5.2 [80]
Ro5028442 Hs Antagonist <4.5 pKi 60
pKi <4.5 (Ki >3x10-5 M) [60]
OPC-21268 Hs Antagonist 4.5 pKi 80
pKi 4.5 [80]
View species-specific antagonist tables
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  67
Tissue Distribution
Lung.
Species:  Human
Technique:  RT-PCR and Northern Blotting.
References:  25
Adult: cerebellum (no change during development).
Newborn: cerebellum, choroid plexus, hippocampus.
Species:  Human
Technique:  RT-PCR and Immunohistochemistry.
References:  38
Kidney: collecting duct, distal convoluted tubule/connecting tubule.
Species:  Rat
Technique:  Immunohistochemistry.
References:  27
Hippocampus.
Species:  Rat
Technique:  RT-PCR.
References:  35
Adult: kidney.
Newborn: brain, kidney.
Species:  Rat
Technique:  RT-PCR.
References:  34
Kidney.
Species:  Rat
Technique:  in situ hybridisation.
References:  55
Kidney: cortical collecting duct, outer medullary collecting duct, inner medullary collecting duct > inner medullary thick limbs, medullary thick ascending limbs, initial cortical collecting duct.
Species:  Rat
Technique:  RT-PCR.
References:  79
Kidney: medullary thick ascending limb, cortical thick ascending limb, cortical collecting duct, outer medullary collecting duct, inner medullary collecting duct.
Species:  Rat
Technique:  Immunohistochemistry.
References:  50
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP levels in CHO cells transfected with the human V2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  75
Measurement of cAMP-sensitive reporter gene activity levels in L cells transfected with the rat V2 receptor.
Species:  Rat
Tissue:  L cells.
Response measured:  Stimulation of acitivity of cAMP-sensitive reporter gene.
References:  44
Measurement of cAMP levels in cultured hippocampal neurons endogenously expressing the putative rat V2 receptor.
Species:  Rat
Tissue:  Cultured hippocampal neurons.
Response measured:  Stimulation of cAMP accumulation.
References:  22
Measurement of cAMP levels in a tubular suspension of medullary thick ascending limb of Henle's loop endogenously expressing the V2 receptor.
Species:  Rat
Tissue:  Medullary thick ascending limb of Henle's loop.
Response measured:  Stimulation of cAMP accumulation.
References:  40
Physiological Functions
Water homeostasis (antidiuretic).
Species:  Rat
Tissue:  In vivo (kidney).
References:  39,47
Nitric oxide production (via the phosphoinositide pathway).
Species:  Rat
Tissue:  Inner medullary collecting duct.
References:  51
Stimulation of an increase in osmotic water permeability.
Species:  Rat
Tissue:  Inner medullary collecting duct.
References:  14
Potentiation of pilocarpine-induced seizures.
Species:  Rat
Tissue:  In vivo (brain).
References:  18
Modulation of nociception.
Species:  Rat
Tissue:  Periaqueductal gray.
References:  88
Regulation of aquaporin-2 (AQP2) expression.
Species:  Rat
Tissue:  In vivo (kidney).
References:  59
Stimulation of renal medullary blood flow.
Species:  Rat
Tissue:  In vivo (kidney).
References:  49
Physiological Consequences of Altering Gene Expression
Mice with siRNA-mediated inhibition of V2 receptor expression in the kidney exhibit a reduced antidiuretic action in response to vasopressin.
Species:  Mouse
Tissue: 
Technique:  RNA interference.
References:  33
Rats with siRNA-mediated inhibition of V2 receptor expression in the periaqueductal gray exhibit a decreased pain threshold.
Species:  Rat
Tissue: 
Technique:  RNA interference.
References:  88
Gene transfer of human AVPR2 into rat myocardium in vivo results in a positive inotropic effect.
Species:  Human
Tissue: 
Technique:  Adenoviral gene transfer.
References:  84
Gene transfer of human AVPR2 into rat cardiomyocyes results in potentiation of contractile force.
Species:  Human
Tissue: 
Technique:  Adenoviral gene transfer.
References:  43
Induction of a nonsense mutation into the AVPR2 receptor gene (Glu198 -> STOP) results in an X-linked nephrogenic diabetes insipidus-like phenotype.
Species:  Mouse
Tissue: 
Technique:  Induced mutation.
References:  89
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Avpr2+|Avpr2tm1Jwe Avpr2tm1Jwe/Avpr2+
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0002136 abnormal kidney physiology PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0001262 decreased body weight PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0002988 decreased urine osmolality PMID: 11104789 
Avpr2+|Avpr2tm1Jwe Avpr2tm1Jwe/Avpr2+
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0002988 decreased urine osmolality PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0003853 dry skin PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0000519 hydronephrosis PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0000189 hypoglycemia PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0003019 increased circulating chloride level PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0005633 increased circulating sodium level PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0002608 increased hematocrit PMID: 11104789 
Avpr2+|Avpr2tm1Jwe Avpr2tm1Jwe/Avpr2+
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0001426 polydipsia PMID: 11104789 
Avpr2+|Avpr2tm1Jwe Avpr2tm1Jwe/Avpr2+
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0001762 polyuria PMID: 11104789 
Avpr2tm1Jwe Avpr2tm1Jwe/Y
involves: 129S1/Sv * 129X1/SvJ * CF-1
MGI:88123  MP:0002082 postnatal lethality PMID: 11104789 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Nephrogenic diabetes insipidus
Disease Ontology: DOID:12387
OMIM: 304800
Orphanet: ORPHA223
Comments: 
References:  2-3,5-7,10,12,20,23,30,36-37,41-42,44-46,53-54,56-57,61-62,65,68-69,74,78,82-83,85
Disease:  Nephrogenic syndrome of inappropriate antidiuresis
Synonyms: Inappropriate antidiuretic hormone secretion syndrome [Orphanet: ORPHA83449]
OMIM: 300539
Orphanet: ORPHA83449
Comments: 
References:  26,31,63
Biologically Significant Variants
Type:  Splice variants
Species:  Rat
Description:  Two splice variants of the V2 receptor have been found in the rat kidney tubules. The longer most abundent form, V2(L), and the shorter form, V2(S), which lacks the 7th transmembrane domain and does not couple to the AC pathway.
References:  28
General Comments
One of the main endocrine functions of arginine vasopressin (AVP, also called ADH) is the facilitation of water re-absorption by the kidney through its action on the V2 vasopressin receptor. Vasopressin inhibits diuresis by binding to V2 vasopressin receptors present on the basolateral membrane of the renal collecting duct cells. The activation of the V2 receptor in renal collecting tubules stimulates adenylate cyclase type 6 through Gs and promotes the cyclic adenosine monophosphate- and protein kinase A-mediated incorporation of water channels (aquaporin 2) into the luminal surface of these cells. Long-term V2 receptor occupation also increases the total aquaporin-2 in the cell through a transcriptional mechanism. The AVP analog dDAVP (desmopressin) is a selective V2 agonist used for the treatment of central diabetes insipidus. It is also used to treat bleeding episodes in patients suffering from hemophilia A and Von Willebrand?s disease, the most frequent congenital bleeding disorders. The possible existence of other extra-renal V2 receptors in mammals is still an open question.

Some molecular biological studies suggesting the presence of extra-renal V2 receptors should be interpreted with caution since the ARHGAP4 (a member of the RhoGTPase activating protein family) gene is immediately adjacent to and orientated towards the V2 receptor gene on opposite strands - the transcriptional units of each gene overlap [29]. Molecular probes (e.g., cDNAs) or primers (e.g., for PCR) to detect V2 receptor mRNA must be carefully designed to exclude detection of ARHGAP4 mRNA. ARHGAP4 is present in specific brain regions including hippocampus, brainstem, striatum and cerebellum [29].

References

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1. Akerlund M, Bossmar T, Brouard R, Kostrzewska A, Laudanski T, Lemancewicz A, Serradeil-Le Gal C, Steinwall M. (1999) Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women. Br J Obstet Gynaecol, 106: 1047-1053. [PMID:10519430]

2. Ala Y, Morin D, Mouillac B, Sabatier N, Vargas R, Cotte N, Déchaux M, Antignac C, Arthus MF, Lonergan M, Turner MS, Balestre MN, Alonso G, Hibert M, Barberis C, Hendy GN, Bichet DG, Jard S. (1998) Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype. J Am Soc Nephrol, 9: 1861-1872. [PMID:9773787]

3. Albertazzi E, Zanchetta D, Barbier P, Faranda S, Frattini A, Vezzoni P, Procaccio M, Bettinelli A, Guzzi F, Parenti M, Chini B. (2000) Nephrogenic diabetes insipidus: functional analysis of new AVPR2 mutations identified in Italian families. J Am Soc Nephrol, 11: 1033-1043. [PMID:10820167]

4. Albright JD, Reich MF, Delos Santos EG, Dusza JP, Sum FW, Venkatesan AM, Coupet J, Chan PS, Ru X, Mazandarani H et al.. (1998) 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J. Med. Chem., 41 (14): 2442-4. [PMID:9651149]

5. Bichet DG. (2006) Nephrogenic diabetes insipidus. Adv Chronic Kidney Dis, 13: 96-104. [PMID:16580609]

6. Bichet DG, Turner M, Morin D. (1998) Vasopressin receptor mutations causing nephrogenic diabetes insipidus. Proc Assoc Am Physicians, 110: 387-394. [PMID:9756088]

7. Birnbaumer M. (1999) Vasopressin receptor mutations and nephrogenic diabetes insipidus. Arch Med Res, 30: 465-474. [PMID:10714359]

8. Birnbaumer M, Seibold A, Gilbert S, Ishido M, Barberis C, Antaramian A, Brabet P, Rosenthal W. (1992) Molecular cloning of the receptor for human antidiuretic hormone. Nature., 357: 333-335. [PMID:1534149]

9. Breton C, Chellil H, Kabbaj-Benmansour M, Carnazzi E, Seyer R, Phalipou S, Morin D, Durroux T, Zingg HH, Barberis C, Mouillac B. (2001) Direct identification of human oxytocin receptor-binding domains using a photoactivatable cyclic peptide antagonist: comparison with the human V1a vasopressin receptor. J Biol Chem, 276: 26931-26941. [PMID:11337500]

10. Chan Seem CP, Dossetor JF, Penney MD. (1999) Nephrogenic diabetes insipidus due to a new mutation of the arginine vasopressin V2 receptor gene in a girl presenting with non-accidental injury. Ann Clin Biochem, 36: 779-782. [PMID:10586320]

11. Cheng LL, Stoev S, Manning M, Derick S, Pena A, Mimoun MB, Guillon G. (2004) Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem, 47: 2375-2388. [PMID:15084136]

12. Cheong HI, Park HW, Ha IS, Moon HN, Choi Y, Ko KW, Jun JK. (1997) Six novel mutations in the vasopressin V2 receptor gene causing nephrogenic diabetes insipidus. Nephron, 75: 431-437. [PMID:9127330]

13. Chini B, Mouillac B, Ala Y, Balestre MN, Trumpp-Kallmeyer S, Hoflack J, Elands J, Hibert M, Manning M, Jard S et al.. (1995) Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor. EMBO J., 14 (10): 2176-82. [PMID:7774575]

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Stephen Lolait, Daniel Bichet, Michel Bouvier, Bice Chini, Gerald Gimpl, Gilles Guillon, Tadashi Kimura, Mark Knepper, Maurice Manning, Bernard Mouillac, Claudine Serradeil-Le Gal, Melvyn Soloff, Joseph G. Verbalis, Mark Wheatley, Hans H. Zingg.
Vasopressin and oxytocin receptors: V2 receptor. Last modified on 21/02/2018. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=368.