BPS/IUPHAR Guide to Pharmacology | GRAC GPCR FAMILIES

Orphan and other 7TM receptors

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Class A Orphans
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Other 7TM proteins
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Adiponectin receptors

Class A Orphans

More information on this family may be found on the IUPHAR-DB family and introduction pages.

Table 1 lists a number of putative GPCRs identified by IUPHAR [21], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.

Table 1: Class A orphan GPCRs with putative endogenous ligands

In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).

Class A orphans CMKLR1 and GPR32 are reported to respond to endogenous ligands resolvin E1 and resolvin D2 respectively and have been grouped together (Resolvin receptors).

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Receptors

BB₃ receptor Show »« Hide

GPR1 Show »« Hide

Nomenclature

GPR1

Other names

GPR1, G-protein coupled receptor 1, probable G-protein coupled receptor 1, G protein-coupled receptor 1

IUPHAR-DB

GPR1

Genes

GPR1 (Hs), Gpr1 (Mm), Gpr1 (Rn)

Ensembl ID

ENSG00000183671 (Hs), ENSMUSG00000046856 (Mm)

Principal transduction

Endogenous agonists
(pK_i)

chemerin C-terminal peptide (Selective) [105]

Comment

Reported to act as a co-receptor for HIV [83].

GPR3 Show »« Hide

Nomenclature	GPR3
Other names	GPCR3, ACCA, Gpcr21, GPR3, G-protein coupled receptor 3, ACCA orphan receptor, adenylate cyclase constitutive activator, G protein-coupled receptor 3, G protein-coupled receptor R4, G-protein-coupled receptor R4, Gpcr20
IUPHAR-DB	GPR3
Genes	GPR3 (Hs), Gpr3 (Mm), Gpr3 (Rn)
Ensembl ID	ENSG00000181773 (Hs), ENSMUSG00000049649 (Mm), ENSRNOG00000009540 (Rn)
Principal transduction	-
Comment	Fails to respond to a variety of lipid-derived agents [102]. Reported to activate adenylyl cyclase constitutively through G_s [19]. Gene disruption results in premature ovarian aging [43], reduced β-amyloid deposition [91] and heightened pain behaviours [80] in mice.

GPR4 Show »« Hide

Nomenclature	GPR4
Other names	MGC116369, GPR4, G-protein coupled receptor 4, G-protein coupled receptor 19, GPR19, Gpr4_predicted, LOC308408, G protein-coupled receptor 4, G protein-coupled receptor 4 (predicted)
IUPHAR-DB	GPR4
Genes	GPR4 (Hs), Gpr4 (Mm), Gpr4 (Rn)
Ensembl ID	ENSG00000177464 (Hs), ENSMUSG00000044317 (Mm), ENSRNOG00000016362 (Rn)
Principal transduction	-
Comment	Reportedly a proton-sensing G-protein-coupled receptor [49,53,92]. An initial report suggesting activation by lysophosphatidylcholine, sphingosylphosphorylcholine [109] has been retracted [1]. Gene disruption is associated with increased perinatal mortality and impaired vascular proliferation [101].

GPR6 Show »« Hide

Nomenclature	GPR6
Other names	Sphingosine 1-phosphate receptor GPR6, GPR6, G-protein coupled receptor 6, Sphingosine 1-phosphate receptor, G protein-coupled receptor 6, putative G protein-coupled receptor (CNL3), AI852874, Gm233
IUPHAR-DB	GPR6
Genes	GPR6 (Hs), Gpr6 (Mm), Gpr6 (Rn)
Ensembl ID	ENSG00000146360 (Hs), ENSMUSG00000046922 (Mm)
Principal transduction	-
Comment	Fails to respond to a variety of lipid-derived agents [102]. Reported to activate adenylyl cyclase constitutively through G_s and to be located intracellularly [73].

GPR12 Show »« Hide

Nomenclature	GPR12
Other names	GPCR21, MGC156481, Gpcr12, Gpcr01, Gpcr20, GPR12, G-protein coupled receptor 12, GPCR12, R334
IUPHAR-DB	GPR12
Genes	GPR12 (Hs), Gpr12 (Mm), Gpr12 (Rn)
Ensembl ID	ENSG00000132975 (Hs), ENSMUSG00000041468 (Mm), ENSRNOG00000039832 (Rn)
Principal transduction	-
Comment	Fails to respond to a variety of lipid-derived agents [102]. Gene disruption results in dyslipidemia and obesity [5].

GPR15 Show »« Hide

Nomenclature	GPR15
Other names	BOB, GPR15, G protein-coupled receptor 15, Brother of Bonzo, G-protein coupled receptor 15, Gpr15_predicted, LOC288181, G protein-coupled receptor 15 (predicted), 4933439K08Rik, BoB
IUPHAR-DB	GPR15
Genes	GPR15 (Hs), Gpr15 (Mm), Gpr15 (Rn)
Ensembl ID	ENSG00000154165 (Hs), ENSMUSG00000047293 (Mm), ENSRNOG00000039680 (Rn)
Principal transduction	-
Comment	Reported to act as a co-receptor for HIV [17].

GPR17 Show »« Hide

Nomenclature

GPR17

Other names

Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, P2Y-like receptor, R12, GPR17, G-protein coupled receptor 17, G protein-coupled receptor 17, uracil nucleotide/cysteinyl leukotriene receptor, AI853548

IUPHAR-DB

GPR17

Genes

GPR17 (Hs), Gpr17 (Mm), Gpr17 (Rn)

Ensembl ID

ENSG00000144230 (Hs), ENSMUSG00000052229 (Mm), ENSRNOG00000025745 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

LTC₄ (pEC₅₀ 7.83 – 9.48) [13]

LTD₄ (pEC₅₀ 8.14 – 8.36) [13]

UDP-glucose (pEC₅₀ 5.92 – 9.52) [4,13]

UDP-galactose (pEC₅₀ 5.96 – 8.92) [4,13]

UDP (pEC₅₀ 5.97 – 8.8) [4,13]

Comment

Dual leukotriene and UDP receptor [13]. Reported to antagonize CysLT1 receptor signalling in vivo and in vitro [57].

GPR18 Show »« Hide

Nomenclature

GPR18

Other names

GPR18, G-protein coupled receptor 18, NAGly receptor, N-arachidonyl glycine receptor, GPCRW, Gpr18_predicted, LOC306191, LOC679957, MGC156838, G protein-coupled receptor 18, G protein-coupled receptor 18 (predicted), similar to G protein-coupled receptor 18

IUPHAR-DB

GPR18

Genes

GPR18 (Hs), Gpr18 (Mm), Gpr18 (Rn)

Ensembl ID

ENSG00000125245 (Hs), ENSMUSG00000050350 (Mm), ENSRNOG00000012628 (Rn)

Principal transduction

G_i/o [40]

Endogenous agonists
(pK_i)

N-arachidonoylglycine [40]

GPR19 Show »« Hide

GPR20 Show »« Hide

Nomenclature	GPR20
Other names	Gpcr5-1, P2Y4, GPR20, G-protein coupled receptor 20, G protein-coupled receptor 20, G protein-coupled receptor 5-1, A430106B11Rik
IUPHAR-DB	GPR20
Genes	GPR20 (Hs), Gpr20 (Mm), Gpr20 (Rn)
Ensembl ID	ENSG00000204882 (Hs), ENSMUSG00000045281 (Mm), ENSRNOG00000007795 (Rn)
Principal transduction	-
Comment	Reported to inhibit adenylyl cyclase constitutively through G_i/o [25].

GPR21 Show »« Hide

Nomenclature	GPR21
Other names	LOC689917, G protein-coupled receptor 21, probable G-protein coupled receptor 21, similar to G protein-coupled receptor 21, C230004C13Rik
IUPHAR-DB	GPR21
Genes	GPR21 (Hs), Gpr21 (Mm), Gpr21 (Rn)
Ensembl ID	ENSG00000188394 (Hs), ENSMUSG00000053164 (Mm), ENSRNOG00000042269 (Rn)
Principal transduction	-

GPR22 Show »« Hide

Nomenclature	GPR22
Other names	Gpr22_predicted, LOC298944, G protein-coupled receptor 22, G protein-coupled receptor 22 (predicted), probable G-protein coupled receptor 22, 2900068K05Rik, AW061316
IUPHAR-DB	GPR22
Genes	GPR22 (Hs), Gpr22 (Mm), Gpr22 (Rn)
Ensembl ID	ENSG00000172209 (Hs), ENSMUSG00000044067 (Mm), ENSRNOG00000008423 (Rn)
Principal transduction	-
Comment	Reported to inhibit adenylyl cyclase constitutively through G_i/o; gene disruption results in increased severity of functional decompensation following aortic banding [2]. Identified as a susceptibility locus for osteoarthritis [20,38,93].

GPR25 Show »« Hide

Nomenclature	GPR25
Other names	GPR25, G-protein coupled receptor 25, probable G-protein coupled receptor 25, Gpr25_predicted, LOC363993, G protein-coupled receptor 25, G protein-coupled receptor 25 (predicted), LOC383563, Gm1300
IUPHAR-DB	GPR25
Genes	GPR25 (Hs), Gpr25 (Mm), Gpr25 (Rn)
Ensembl ID	ENSG00000170128 (Hs), ENSMUSG00000052759 (Mm), ENSRNOG00000008603 (Rn)
Principal transduction	-

GPR26 Show »« Hide

Nomenclature	GPR26
Other names	GPR26, G-protein coupled receptor 26, G protein-coupled receptor 26, probable G-protein coupled receptor 26, 9630036A11Rik
IUPHAR-DB	GPR26
Genes	GPR26 (Hs), Gpr26 (Mm), Gpr26 (Rn)
Ensembl ID	ENSG00000154478 (Hs), ENSMUSG00000040125 (Mm)
Principal transduction	-
Comment	Has been reported to activate adenylyl cyclase constitutively through G_s [34].

GPR27 Show »« Hide

Nomenclature	GPR27
Other names	SREB1, super conserved receptor expressed in brain 1, super-conserved receptor expressed in brain 1, GPR27, G-protein coupled receptor 27, probable G-protein coupled receptor 27, G protein-coupled receptor 27
IUPHAR-DB	GPR27
Genes	GPR27 (Hs), Gpr27 (Mm), Gpr27 (Rn)
Ensembl ID	ENSG00000170837 (Hs), ENSMUSG00000072875 (Mm), ENSRNOG00000010880 (Rn)
Principal transduction	-

GPR31 Show »« Hide

Nomenclature

GPR31

Other names

bA517H2.2, GPR31, G protein-coupled receptor 31, probable G-protein coupled receptor 31, HETER1, 12-HETER, hydroxyeicosatetraenoic (HETE) acid receptor 1, 12-(S)-HETE acid receptor, Gpr31_predicted, LOC292310, G protein-coupled receptor 31 (predicted)

IUPHAR-DB

GPR31

Genes

GPR31 (Hs), Gpr31c (Mm), Gpr31 (Rn)

Ensembl ID

ENSG00000120436 (Hs), ENSMUSG00000071311 (Mm), ENSRNOG00000039255 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

12S-HETE (Selective) (pEC₅₀ 9.55 - Mouse) [23]

GPR32 Show »« Hide

Nomenclature

GPR32

Other names

GPR32, G-protein coupled receptor 32, probable G-protein coupled receptor 32, RvD1, RVDR1, resolvin D1 receptor

IUPHAR-DB

GPR32

Genes

GPR32 (Hs)

Ensembl ID

ENSG00000142511 (Hs)

Principal transduction

Not yet established

Rank order of potency

resolvin D1 > LXA₄

Endogenous agonists
(pK_i)

resolvin D1 (Selective) (pEC₅₀ 11.06) [42]

LXA₄ (Selective) (pEC₅₀ 9.7) [42]

Radioligands
(K_d)

[³H]resolvin D1 (2x10^-10 M) [42]

GPR33 Show »« Hide

Nomenclature	GPR33
Other names	G protein-coupled receptor 33, pseudogene, G protein-coupled receptor 33 pseudogene, G protein-coupled receptor 33, Gpr33, Gpr33_predicted, LOC299007, G protein-coupled receptor 33 (predicted), probable G-protein coupled receptor 33
IUPHAR-DB	GPR33
Genes	GPR33 (Hs), Gpr33 (Mm), Gpr33 (Rn)
Ensembl ID	ENSG00000214943 (Hs), ENSMUSG00000035148 (Mm), ENSRNOG00000038990 (Rn)
Principal transduction	-

GPR34 Show »« Hide

Nomenclature

GPR34

Other names

GPR34, GPR34_predicted, G protein-coupled receptor 34, G-protein-coupled receptor GPR34, G-protein-coupled receptor GPR34 (predicted), probable G-protein coupled receptor 34

IUPHAR-DB

GPR34

Genes

GPR34 (Hs), Gpr34 (Mm), Gpr34 (Rn)

Ensembl ID

ENSG00000171659 (Hs), ENSMUSG00000040229 (Mm), ENSRNOG00000039759 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

lysophosphatidylserine (Selective) (pEC₅₀ 6.57 – 6.89) [39,87]

Comment

Fails to respond to a variety of lipid-derived agents [102]. Gene disruption results in an enhanced immune response [47].

GPR35 Show »« Hide

Nomenclature

GPR35

Other names

GPR35, G-protein coupled receptor 35, G protein-coupled receptor 35, Kynurenic acid receptor, KYNA receptor, G-protein coupled receptor 3, Gpr35_predicted, LOC367315, G protein-coupled receptor 35 (predicted)

IUPHAR-DB

GPR35

Genes

GPR35 (Hs), Gpr35 (Mm), Gpr35 (Rn)

Ensembl ID

ENSG00000178623 (Hs), ENSMUSG00000026271 (Mm), ENSRNOG00000024030 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

LPA (pEC₅₀ 7.3 – 7.52) [71]

kynurenic acid (pEC₅₀ 4.41) [95]

Comment

Reported to respond to the phosphodiesterase inhibitor zaprinast [89] and the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid [90], the pharmaceutical adjuvant pamoic acid [108] and tyrosine kinase inhibitor tyrphostins [15].

GPR37 Show »« Hide

Nomenclature

GPR37

Other names

ETBR-LP-1, PAELR, EDNRBL, Endothelin B receptor-like protein 1, EDNRLB, GPR37, G protein-coupled receptor 37 (endothelin receptor type B-like), hET(B)R-LP, probable G-protein coupled receptor 37, endothelin receptor type B-like, Parkin-associated endothelin receptor-like receptor, MGC105347, G protein-coupled receptor 37, G-protein coupled receptor CNS1, Pael-R, parkin-associated endothelin B-like receptor, AI848630

IUPHAR-DB

GPR37

Genes

GPR37 (Hs), Gpr37 (Mm), Gpr37 (Rn)

Ensembl ID

ENSG00000170775 (Hs), ENSMUSG00000039904 (Mm), ENSRNOG00000002524 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

neuropeptide head activator (pEC₅₀ 7.96 – 8.48) [78]

Comment

Reported to associate and regulate the dopamine transporter [63] and to be a substrate for parkin [61]. Gene disruption results in altered striatal signalling [62].

GPR37L1 Show »« Hide

Nomenclature	GPR37L1
Other names	G-protein coupled receptor 37-like 1, D0Kist8, CAG-18, ETBR-LP-2, GPR37L1, ET(B)R-LP-2, ETBRLP2, G protein-coupled receptor 37 like 1, endothelin B receptor-like protein 2, G-protein coupled receptor CNS2, AW047233
IUPHAR-DB	GPR37L1
Genes	GPR37L1 (Hs), Gpr37l1 (Mm), Gpr37l1 (Rn)
Ensembl ID	ENSG00000170075 (Hs), ENSMUSG00000026424 (Mm), ENSRNOG00000006237 (Rn)
Principal transduction	-

GPR39 Show »« Hide

Nomenclature

GPR39

Other names

MGC149541, GPR39, G-protein coupled receptor 39, Gpr39_predicted, LOC288995, G protein-coupled receptor 39, G protein-coupled receptor 39 (predicted), 4933415E13Rik

IUPHAR-DB

GPR39

Genes

GPR39 (Hs), Gpr39 (Mm), Gpr39 (Rn)

Ensembl ID

ENSG00000183840 (Hs), ENSMUSG00000026343 (Mm), ENSRNOG00000021586 (Rn)

Principal transduction

Selective agonists
(pK_i)

Zn²⁺ [28]

Comment

obestatin was reported initially as an endogenous ligand [106], but subsequent studies failed to reproduce these findings. Has been reported to be down-regulated in adipose tissue in obesity-related diabetes [9]. Gene disruption results in obesity [75].

GPR45 Show »« Hide

Nomenclature	GPR45
Other names	PSP24, PSP24-1, PSP24-alpha, PSP24A, GPR45, G-protein coupled receptor 45, high-affinity lysophosphatidic acid receptor, probable G-protein coupled receptor 45, PSP24(ALPHA), Gpr45_predicted, LOC301372, G protein-coupled receptor 45, G protein-coupled receptor 45 (predicted), PSP24alpha, 9230112G11Rik, AW046772
IUPHAR-DB	GPR45
Genes	GPR45 (Hs), Gpr45 (Mm), Gpr45 (Rn)
Ensembl ID	ENSG00000135973 (Hs), ENSMUSG00000041907 (Mm), ENSRNOG00000016446 (Rn)
Principal transduction	-

GPR50 Show »« Hide

Nomenclature	GPR50
Other names	H9, MGC125342, MTNRL, GPR50, G-protein coupled receptor 50, Mel1c, melatonin-related receptor
IUPHAR-DB	GPR50
Genes	GPR50 (Hs), Gpr50 (Mm), Gpr50 (Rn)
Ensembl ID	ENSG00000102195 (Hs), ENSMUSG00000056380 (Mm), ENSRNOG00000011335 (Rn)
Principal transduction	-
Comment	A potential orthologue of an avian melatonin receptor [16].

GPR52 Show »« Hide

Nomenclature	GPR52
Other names	MGC111751, EG620246, GPR52, G-protein coupled receptor 52, probable G-protein coupled receptor 52, LOC680192, G protein-coupled receptor 52, similar to Probable G-protein coupled receptor 52
IUPHAR-DB	GPR52
Genes	GPR52 (Hs), Gpr52 (Mm), Gpr52 (Rn)
Ensembl ID	ENSG00000203737 (Hs)
Principal transduction	-

GPR55 Show »« Hide

GPR61 Show »« Hide

Nomenclature	GPR61
Other names	BALGR, GPCR3, GPR61, G protein-coupled receptor 61, Biogenic amine receptor-like G-protein coupled receptor, probable G-protein coupled receptor 61, biogenic amine receptor-like GPCR, Gpr61_predicted, LOC310780, G protein-coupled receptor 61 (predicted)
IUPHAR-DB	GPR61
Genes	GPR61 (Hs), Gpr61 (Mm), Gpr61 (Rn)
Ensembl ID	ENSG00000156097 (Hs), ENSMUSG00000046793 (Mm), ENSRNOG00000019738 (Rn)
Principal transduction	-

GPR62 Show »« Hide

Nomenclature	GPR62
Other names	KPG_005, MGC26943, GPCR8, LOC501049, RGD1560166_predicted, similar to Probable G-protein coupled receptor 62 (hGPCR8), similar to Probable G-protein coupled receptor 62 (hGPCR8) (predicted), 4933402E03Rik
IUPHAR-DB	GPR62
Genes	GPR62 (Hs), Gpr62 (Mm), RGD1560166 (Rn)
Ensembl ID	ENSG00000180929 (Hs), ENSMUSG00000091735 (Mm), ENSRNOG00000022567 (Rn)
Principal transduction	-

GPR63 Show »« Hide

Nomenclature	GPR63
Other names	PSP24B, PSP24(beta), PSP24-2, Gpr63_predicted, LOC297952, G protein-coupled receptor 63, G protein-coupled receptor 63 (predicted), probable G-protein coupled receptor 63, PSP24beta
IUPHAR-DB	GPR63
Genes	GPR63 (Hs), Gpr63 (Mm), Gpr63 (Rn)
Ensembl ID	ENSG00000112218 (Hs), ENSMUSG00000040372 (Mm), ENSRNOG00000007675 (Rn)
Principal transduction	-
Comment	Fails to respond to a variety of lipid-derived agents [102].

GPR65 Show »« Hide

Nomenclature	GPR65
Other names	TDAG8, Psychosine receptor, T cell death-associated protein 8, Dig1, Gpcr25, GPR65, G-protein coupled receptor 65, hTDAG8, Gpr65_predicted, LOC299242, G-protein coupled receptor 65 (predicted), T cell death associated protein 8, rCG_20955
IUPHAR-DB	GPR65
Genes	GPR65 (Hs), Gpr65 (Mm), Gpr65 (Rn)
Ensembl ID	ENSG00000140030 (Hs), ENSMUSG00000021886 (Mm), ENSRNOG00000003806 (Rn)
Principal transduction	-
Comment	Reportedly a proton-sensing G-protein-coupled receptor [31,96]. Reported to activate adenylyl cyclase; gene disruption leads to reduced eosinophlia in models of allergic airway disease [41].

GPR68 Show »« Hide

Nomenclature	GPR68
Other names	Sphingosylphosphorylcholine receptor, Ovarian cancer G-protein coupled receptor 1, OGR-1, GPR12A, MGC111379, OGR1, Gpr68_predicted, LOC314386, G protein-coupled receptor 68, G protein-coupled receptor 68 (predicted), BB131428
IUPHAR-DB	GPR68
Genes	GPR68 (Hs), Gpr68 (Mm), Gpr68 (Rn)
Ensembl ID	ENSG00000119714 (Hs), ENSMUSG00000047415 (Mm), ENSRNOG00000027863 (Rn)
Principal transduction	-
Comment	Reportedly a proton-sensing G-protein-coupled receptor [53].

GPR75 Show »« Hide

Nomenclature

GPR75

Other names

GPR-chr2, WI-31133, WI31133, GPR75, G-protein coupled receptor 75, GPRchr2, probable G-protein coupled receptor 75, LOC498434, RGD1566385, RGD1566385_predicted, G protein-coupled receptor 75, G protein-coupled receptor GPR75, similar to G protein-coupled receptor GPR75, similar to G protein-coupled receptor GPR75 (predicted)

IUPHAR-DB

GPR75

Genes

GPR75 (Hs), Gpr75 (Mm), Gpr75 (Rn)

Ensembl ID

ENSG00000119737 (Hs), ENSMUSG00000043999 (Mm), ENSRNOG00000022176 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

CCL5 (pEC₅₀ 9.59) [30]

GPR78 Show »« Hide

Nomenclature	GPR78
Other names	GPR78, G-protein coupled receptor 78
IUPHAR-DB	GPR78
Genes	GPR78 (Hs)
Ensembl ID	ENSG00000155269 (Hs)
Principal transduction	-

GPR82 Show »« Hide

GPR83 Show »« Hide

Nomenclature	GPR83
Other names	GPR72, KIAA1540, glucocorticoid-induced receptor, GIR, RP105, RP39, RP82, GPR83, G-protein coupled receptor 83, G protein-coupled receptor 83, G-protein coupled receptor 72, glucocorticoid induced receptor, probable G-protein coupled receptor, JP05 [7], G protein-coupled receptor 72, probable G-protein coupled receptor 83, AW045253
IUPHAR-DB	GPR83
Genes	GPR83 (Hs), Gpr83 (Mm), Gpr83 (Rn)
Ensembl ID	ENSG00000123901 (Hs), ENSMUSG00000031932 (Mm), ENSRNOG00000030318 (Rn)
Principal transduction	-

GPR84 Show »« Hide

Nomenclature	GPR84
Other names	EX33, GPR84, G-protein coupled receptor 84, G protein-coupled receptor 84, Inflammation-related G-protein coupled receptor EX33, GPCR4, LOC688730, similar to G protein-coupled receptor 84
IUPHAR-DB	GPR84
Genes	GPR84 (Hs), Gpr84 (Mm), Gpr84 (Rn)
Ensembl ID	ENSG00000139572 (Hs), ENSMUSG00000063234 (Mm), ENSRNOG00000036834 (Rn)
Principal transduction	-
Comment	Reportedly binds medium chain fatty acids [94].

GPR85 Show »« Hide

Nomenclature	GPR85
Other names	SREB2, Super Conserved Receptor Expressed in Brain 2, Srep2, MGC105281, GPR85, G protein-coupled receptor 85, Super conserved receptor expressed in brain 2, seven transmembrane helix receptor, probable G-protein coupled receptor 85, SREB, PKrCx1, 2900026B03Rik, rgpr85
IUPHAR-DB	GPR85
Genes	GPR85 (Hs), Gpr85 (Mm), Gpr85 (Rn)
Ensembl ID	ENSG00000164604 (Hs), ENSMUSG00000048216 (Mm), ENSRNOG00000024636 (Rn)
Principal transduction	-

GPR87 Show »« Hide

Nomenclature

GPR87

Other names

GPR95, FKSG78, KPG_002, MGC131898, Gpr87_predicted, LOC310443, G protein-coupled receptor 87, G protein-coupled receptor 87 (predicted), G-protein coupled receptor 87

IUPHAR-DB

GPR87

Genes

GPR87 (Hs), Gpr87 (Mm), Gpr87 (Rn)

Ensembl ID

ENSG00000138271 (Hs), ENSMUSG00000051431 (Mm), ENSRNOG00000013894 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

LPA (pEC₅₀ 7.44) [65,88]

GPR88 Show »« Hide

Nomenclature	GPR88
Other names	Strg, STRG, GPR88, G-protein coupled receptor 88, probable G-protein coupled receptor 88, G protein coupled receptor 88, G protein-coupled receptor 88, striatum-specific G-protein coupled receptor, AW061286
IUPHAR-DB	GPR88
Genes	GPR88 (Hs), Gpr88 (Mm), Gpr88 (Rn)
Ensembl ID	ENSG00000181656 (Hs), ENSMUSG00000068696 (Mm), ENSRNOG00000026953 (Rn)
Principal transduction	-
Comment	Gene disruption results in altered striatal signalling [51].

GPR101 Show »« Hide

Nomenclature	GPR101
Other names	GPCR6, RGD1564196, GPR101, G-protein coupled receptor 101, probable G-protein coupled receptor 101, Gpr101_predicted, LOC317608, RGD1564196_predicted, G protein-coupled receptor 101, G protein-coupled receptor 101 (predicted), similar to G protein-coupled receptor 101, similar to G protein-coupled receptor 101 (predicted), LOC245424, Gm365
IUPHAR-DB	GPR101
Genes	GPR101 (Hs), Gpr101 (Mm), Gpr101 (Rn)
Ensembl ID	ENSG00000165370 (Hs), ENSMUSG00000036357 (Mm), ENSRNOG00000027658 (Rn)
Principal transduction	-

GPR119 Show »« Hide

GPR132 Show »« Hide

Nomenclature	GPR132
Other names	G2A, MGC99642, GPR132, G-protein coupled receptor 132, G2 accumulation protein, G protein-coupled receptor G2A, probable G-protein coupled receptor 132, G2 accumulation, Gpr132_predicted, LOC314480, G protein-coupled receptor 132, G protein-coupled receptor 132 (predicted)
IUPHAR-DB	GPR132
Genes	GPR132 (Hs), Gpr132 (Mm), Gpr132 (Rn)
Ensembl ID	ENSG00000183484 (Hs), ENSMUSG00000021298 (Mm), ENSRNOG00000013914 (Rn)
Principal transduction	-
Comment	Reportedly a proton-sensing G protein-coupled receptor[66]. Reported to respond to lysophosphatidylcholine [35], but later retracted [98].

GPR135 Show »« Hide

Nomenclature	GPR135
Other names	PAFR, HUMNPIIY20, GPR135, G-protein coupled receptor 135, probable G-protein coupled receptor 135, G protein-coupled receptor 135
IUPHAR-DB	GPR135
Genes	GPR135 (Hs), Gpr135 (Mm), Gpr135 (Rn)
Ensembl ID	ENSG00000181619 (Hs), ENSMUSG00000043398 (Mm), ENSRNOG00000004499 (Rn)
Principal transduction	-

GPR139 Show »« Hide

Nomenclature	GPR139
Other names	PGR3, GPRg1, GPR139, G-protein coupled receptor 139, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3, probable G-protein coupled receptor 139, GPRG1, Gpr139_predicted, LOC293545, G protein-coupled receptor 139, G protein-coupled receptor 139 (predicted), LOC209776, Gm495
IUPHAR-DB	GPR139
Genes	GPR139 (Hs), Gpr139 (Mm), Gpr139 (Rn)
Ensembl ID	ENSG00000180269 (Hs), ENSMUSG00000066197 (Mm), ENSRNOG00000023863 (Rn)
Principal transduction	-

GPR141 Show »« Hide

Nomenclature	GPR141
Other names	PGR13, GPR141, G-protein coupled receptor 141, G-protein coupled receptor PGR13, probable G-protein coupled receptor 141, axor115, G protein-coupled receptor 141
IUPHAR-DB	GPR141
Genes	GPR141 (Hs), Gpr141 (Mm), Gpr141 (Rn)
Ensembl ID	ENSG00000187037 (Hs), ENSMUSG00000053101 (Mm), ENSRNOG00000042801 (Rn)
Principal transduction	-

GPR142 Show »« Hide

Nomenclature	GPR142
Other names	PGR2, KIF19, GPR142, G-protein coupled receptor 142, G-protein coupled receptor PGR2, probable G-protein coupled receptor 142, AXOR103, LOC501735, RGD1559926, RGD1559926_predicted, G protein-coupled receptor 142, similar to G protein-coupled receptor 142, similar to G protein-coupled receptor 142 (predicted)
IUPHAR-DB	GPR142
Genes	GPR142 (Hs), Gpr142 (Mm), Gpr142 (Rn)
Ensembl ID	ENSG00000196169 (Hs), ENSMUSG00000034677 (Mm), ENSRNOG00000024446 (Rn)
Principal transduction	-

GPR146 Show »« Hide

Nomenclature	GPR146
Other names	PGR8, GPR146, G-protein coupled receptor 146, G-protein coupled receptor PGR8, AXOR120, LOC498153, RGD1560731, RGD1560731_predicted, G protein-coupled receptor 146, probable G-protein coupled receptor 146, similar to G protein-coupled receptor 146, similar to G protein-coupled receptor 146 (predicted), BC003323
IUPHAR-DB	GPR146
Genes	GPR146 (Hs), Gpr146 (Mm), Gpr146 (Rn)
Ensembl ID	ENSG00000164849 (Hs), ENSMUSG00000044197 (Mm), ENSRNOG00000001288 (Rn)
Principal transduction	-

GPR148 Show »« Hide

Nomenclature	GPR148
Other names	PGR6, BTR, brain and testis restricted GPCR, GPR148, G-protein coupled receptor 148, G-protein coupled receptor PGR6, probable G-protein coupled receptor 148
IUPHAR-DB	GPR148
Genes	GPR148 (Hs)
Ensembl ID	ENSG00000173302 (Hs)
Principal transduction	-

GPR149 Show »« Hide

Nomenclature	GPR149
Other names	PGR10, IEDA, GPR149, G-protein coupled receptor 149, G-protein coupled receptor PGR10, probable G-protein coupled receptor 149, R35, G protein-coupled receptor 149, induced early in differentiating astrocytes gene protein, orphan seven transmembrane receptor, 9630018L10Rik
IUPHAR-DB	GPR149
Genes	GPR149 (Hs), Gpr149 (Mm), Gpr149 (Rn)
Ensembl ID	ENSG00000174948 (Hs), ENSMUSG00000043441 (Mm), ENSRNOG00000014793 (Rn)
Principal transduction	-
Comment	Gene disruption results in enhanced fertility [18].

GPR150 Show »« Hide

Nomenclature	GPR150
Other names	PGR11, GPR150, G-protein coupled receptor 150, seven transmembrane helix receptor, probable G-protein coupled receptor 150, AXOR70, LOC499486, RGD1564729, RGD1564729_predicted, G protein-coupled receptor 150, similar to G protein-coupled receptor 150, similar to G protein-coupled receptor 150 (predicted), C030001A19Rik
IUPHAR-DB	GPR150
Genes	GPR150 (Hs), Gpr150 (Mm), Gpr150 (Rn)
Ensembl ID	ENSG00000178015 (Hs), ENSMUSG00000045509 (Mm), ENSRNOG00000026944 (Rn)
Principal transduction	-

GPR151 Show »« Hide

Nomenclature	GPR151
Other names	PGR7, GALR4, GALRL, GPCR-2037, galanin receptor 4, GPR151, G-protein coupled receptor 151, G protein-coupled receptor 151, G-protein coupled receptor PGR7, putative G-protein coupled receptor, probable G-protein coupled receptor 151, galanin receptor-like GPCR, AXOR40, nGPCR-2037, putative G protein-coupled receptor nGPCR-2037, C130082O03Rik
IUPHAR-DB	GPR151
Genes	GPR151 (Hs), Gpr151 (Mm), Gpr151 (Rn)
Ensembl ID	ENSG00000173250 (Hs), ENSMUSG00000042816 (Mm), ENSRNOG00000027103 (Rn)
Principal transduction	-

GPR152 Show »« Hide

Nomenclature	GPR152
Other names	PGR1, PGR5, MGC148162, GPR152, G-protein coupled receptor 152, G protein-coupled receptor 152, probable G-protein coupled receptor 152, G-protein coupled receptor PGR5, LOC688884, similar to putative G-protein coupled receptor, LOC269053, A930009H15Rik, Gm673
IUPHAR-DB	GPR152
Genes	GPR152 (Hs), Gpr152 (Mm), Gpr152 (Rn)
Ensembl ID	ENSG00000175514 (Hs), ENSMUSG00000044724 (Mm)
Principal transduction	-

GPR153 Show »« Hide

Nomenclature	GPR153
Other names	PGR1, DKFZp762B2210, G protein-coupled receptor 153, probable G-protein coupled receptor 153, 1110065N12Rik, AI449320
IUPHAR-DB	GPR153
Genes	GPR153 (Hs), Gpr153 (Mm), Gpr153 (Rn)
Ensembl ID	ENSG00000158292 (Hs), ENSMUSG00000042804 (Mm)
Principal transduction	-

GPR160 Show »« Hide

GPR161 Show »« Hide

Nomenclature	GPR161
Other names	RE2, FLJ33952, GPR161, G-protein coupled receptor 161, G-protein coupled receptor RE2, LOC289180, RGD1563245, RGD1563245_predicted, G protein-coupled receptor 161, similar to G protein-coupled receptor 161, similar to G protein-coupled receptor 161 (predicted), LOC240888, vl, Gm208Gpr
IUPHAR-DB	GPR161
Genes	GPR161 (Hs), Gpr161 (Mm), Gpr161 (Rn)
Ensembl ID	ENSG00000143147 (Hs), ENSMUSG00000040836 (Mm)
Principal transduction	-
Comment	Gene disruption is associated with a failure of asymmetric embryonic development in zebrafish [45].

GPR162 Show »« Hide

Nomenclature	GPR162
Other names	A-2, GRCA, GPR162, G-protein coupled receptor 162, Gene-rich cluster gene A protein, gene rich cluster, A, probable G-protein coupled receptor 162, Grca_predicted, Gpr162_predicted, LOC362436, G protein-coupled receptor 162, G protein-coupled receptor 162 (predicted), gene rich cluster, A gene (predicted), BC031437
IUPHAR-DB	GPR162
Genes	GPR162 (Hs), Gpr162 (Mm), Gpr162 (Rn)
Ensembl ID	ENSG00000250510 (Hs), ENSMUSG00000038390 (Mm), ENSRNOG00000016143 (Rn)
Principal transduction	-

GPR171 Show »« Hide

Nomenclature	GPR171
Other names	H963, F730001G15Rik, GPR171, G-protein coupled receptor 171, G protein-coupled receptor 171, G-protein coupled receptor H963, platelet activating receptor homolog, probable G-protein coupled receptor 171, LOC688737, similar to G protein-coupled receptor 171
IUPHAR-DB	GPR171
Genes	GPR171 (Hs), Gpr171 (Mm), Gpr171 (Rn)
Ensembl ID	ENSG00000174946 (Hs), ENSMUSG00000050075 (Mm), ENSRNOG00000025297 (Rn)
Principal transduction	-

GPR173 Show »« Hide

Nomenclature	GPR173
Other names	SREB3, Super conserved receptor expressed in brain 3, GPR173, G-protein coupled receptor 173, probable G-protein coupled receptor 173, G protein coupled receptor 173, 3230401K02Rik
IUPHAR-DB	GPR173
Genes	GPR173 (Hs), Gpr173 (Mm), Gpr173 (Rn)
Ensembl ID	ENSG00000184194 (Hs), ENSMUSG00000056679 (Mm), ENSRNOG00000003272 (Rn)
Principal transduction	-

GPR174 Show »« Hide

Nomenclature	GPR174
Other names	FKSG79, RGD1564689, Gpr174_predicted, LOC302373, RGD1564689_predicted, G protein-coupled receptor 174, G protein-coupled receptor 174 (predicted), probable G-protein coupled receptor 174, similar to putative purinergic receptor FKSG79, similar to putative purinergic receptor FKSG79 (predicted), LOC213439, Gm376
IUPHAR-DB	GPR174
Genes	GPR174 (Hs), Gpr174 (Mm), Gpr174 (Rn)
Ensembl ID	ENSG00000147138 (Hs), ENSMUSG00000073008 (Mm), ENSRNOG00000032970 (Rn)
Principal transduction	-

GPR176 Show »« Hide

Nomenclature	GPR176
Other names	AGR9, Gm1012, HB954, GPR176, G-protein coupled receptor 176, HB-954, probable G-protein coupled receptor 176, Gpr, RBU-15, G-protein coupled receptor AGR9, gene model 1012, (NCBI), putative G protein coupled receptor, LOC381413
IUPHAR-DB	GPR176
Genes	GPR176 (Hs), Gpr176 (Mm), Gpr176 (Rn)
Ensembl ID	ENSG00000166073 (Hs), ENSMUSG00000040133 (Mm), ENSRNOG00000005971 (Rn)
Principal transduction	-

GPR182 Show »« Hide

Nomenclature	GPR182
Other names	hrhAMR, AM-R, G10-D, Gpcr17, Gpcr22, MB10, NOW, ADMR, G-protein coupled receptor 182, GPR182, G10D, AMR, gamrh, adrenomedullin receptor, L1-R [77], G protein-coupled receptor 182
IUPHAR-DB	GPR182
Genes	GPR182 (Hs), Gpr182 (Mm), Gpr182 (Rn)
Ensembl ID	ENSG00000166856 (Hs), ENSMUSG00000058396 (Mm), ENSRNOG00000004311 (Rn)
Principal transduction	-

GPR183 Show »« Hide

Nomenclature

GPR183

Other names

EBV-induced G-protein coupled receptor 2, EBI2, Epstein-Barr virus-induced gene 2, lymphocyte-specific G protein-coupled receptor, EBV-induced G protein-coupled receptor 2, GPR183, Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor), LOC679975, G protein-coupled receptor 183, G-protein coupled receptor 183, similar to EBV-induced G-protein coupled receptor 2 (EBI2)

IUPHAR-DB

GPR183

Genes

GPR183 (Hs), Gpr183 (Mm), Gpr183 (Rn)

Ensembl ID

ENSG00000169508 (Hs), ENSMUSG00000051212 (Mm), ENSRNOG00000025094 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

7α,25-dihydroxycholesterol (Selective) (pEC₅₀ 9.85) [48]

7α,27-dihydroxycholesterol (Selective) (pEC₅₀ 8.89) [48]

7β, 25-dihydroxycholesterol (Selective) (pEC₅₀ 8.68) [48]

7β, 27-dihydroxycholesterol (Selective) (pEC₅₀ 7.29) [48]

7α-hydroxycholesterol (Selective) (pEC₅₀ 7.09) [48]

25-hydroxycholesterol (Selective) (pEC₅₀ 6.9) [48]

7β-hydroxycholesterol (Selective) (pEC₅₀ 5.75) [48]

27-hydroxycholesterol (Selective) (pEC₅₀ 5.52) [48]

Comment

The actions of oxysterols at this receptor have also been described in a study by Hannelouche et al., 2011 [24].

LGR4 Show »« Hide

Nomenclature

LGR4

Other names

GPR48, LGR4, leucine-rich repeat-containing G protein-coupled receptor 4, G-protein coupled receptor 48, G protein-coupled receptor 48, leucine-rich repeat-containing G-protein coupled receptor 4, A330106J01Rik, A930009A08Rik

IUPHAR-DB

LGR4

Genes

LGR4 (Hs), Lgr4 (Mm), Lgr4 (Rn)

Ensembl ID

ENSG00000205213 (Hs), ENSMUSG00000050199 (Mm), ENSRNOG00000005715 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

R-spondin-1 (Selective) [8,14]

R-spondin-2 (Selective) [8,14]

R-spondin-3 (Selective) [8,14]

R-spondin-4 (Selective) [8,14]

Comment

Gene disruption leads to multiple developmental disorders [33,54,86,97].

LGR5 Show »« Hide

Nomenclature

LGR5

Other names

GPR67, GPR49, HG38, FEX, MGC117008, LGR5, Leucine-rich repeat-containing G protein-coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, orphan G protein-coupled receptor HG38, leucine-rich repeat-containing G-protein coupled receptor 5, GRP49, leucine-rich repeat-containing G protein-coupled receptor 5, G protein-coupled receptor 49, Gpr49_predicted, LOC299802, G protein-coupled receptor 49 (predicted), leucine rich repeat containing G protein coupled receptor 5

IUPHAR-DB

LGR5

Genes

LGR5 (Hs), Lgr5 (Mm), Lgr5 (Rn)

Ensembl ID

ENSG00000139292 (Hs), ENSMUSG00000020140 (Mm), ENSRNOG00000004221 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

R-spondin-1 (Selective) [8,14]

R-spondin-2 (Selective) [8,14]

R-spondin-3 (Selective) [8,14]

R-spondin-4 (Selective) [8,14]

LGR6 Show »« Hide

Nomenclature

LGR6

Other names

FLJ14471, VTS20631, LGR6, leucine-rich repeat-containing G protein-coupled receptor 6, gonadotropin receptor, leucine-rich repeat-containing G-protein coupled receptor 6, LOC498233, RGD1560339, RGD1560339_predicted, similar to VTS20631, similar to VTS20631 (predicted), A530037C04Rik

IUPHAR-DB

LGR6

Genes

LGR6 (Hs), Lgr6 (Mm), Lgr6 (Rn)

Ensembl ID

ENSG00000133067 (Hs), ENSMUSG00000042793 (Mm), ENSRNOG00000005093 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

R-spondin-1 (Selective) [8,14]

R-spondin-2 (Selective) [8,14]

R-spondin-3 (Selective) [8,14]

R-spondin-4 (Selective) [8,14]

MAS1 Show »« Hide

Nomenclature

MAS1

Other names

MGC119966, MAS, angiotensin 1-7 receptor [76], c-mas, MAS proto-oncogene, MAS1 oncogene, angiotensin-(1-7) receptor, proto-oncogene Mas, Mas-1

IUPHAR-DB

MAS1

Genes

MAS1 (Hs), Mas1 (Mm), Mas1 (Rn)

Ensembl ID

ENSG00000130368 (Hs), ENSMUSG00000068037 (Mm), ENSRNOG00000014971 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

angiotensin-(1-7) (Selective) [82]

MAS1L Show »« Hide

Nomenclature	MAS1L
Other names	MAS-L, MRG, dJ994E9.2, MAS-R, MGC119987, MAS1 oncogene-like
IUPHAR-DB	MAS1L
Genes	MAS1L (Hs)
Ensembl ID	ENSG00000237284 (Hs)
Principal transduction	-

MRGPRD Show »« Hide

Nomenclature

MRGPRD

Other names

TGR7, MRGD, mrgD, MAS-related GPR, member D, MRGPRD, Beta-alanine receptor, G-protein coupled receptor TGR7, mas-related G protein-coupled MRGD, mas-related G-protein coupled receptor member D, MrgD, MAS-related G-protein coupled receptor, member D, MAS-related gene D, MRGD G protein-coupled receptor, LOC211578, Gm499

IUPHAR-DB

MRGPRD

Genes

MRGPRD (Hs), Mrgprd (Mm), Mrgprd (Rn)

Ensembl ID

ENSG00000172938 (Hs), ENSMUSG00000051207 (Mm), ENSRNOG00000013448 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

β-alanine (pEC₅₀ 4.82) [84]

Comment

Potentially exists as a heteromer with MRGPRE (GPR167, ENSG00000184350, [64])

MRGPRE Show »« Hide

Nomenclature	MRGPRE
Other names	mrgE, GPR167, MGC138408, MRGPRE, MRGE, G protein-coupled receptor 167, G-protein coupled receptor 167, mas-related G protein-coupled MRGE, mas-related G-protein coupled receptor member E, MAS-related GPR, member E, MAS-related G-protein coupled receptor, member E, MAS-related gene E, C130069N09Rik
IUPHAR-DB	MRGPRE
Genes	MRGPRE (Hs), Mrgpre (Mm), Mrgpre (Rn)
Ensembl ID	ENSG00000184350 (Hs), ENSMUSG00000048965 (Mm), ENSRNOG00000020735 (Rn)
Principal transduction	-

MRGPRF Show »« Hide

Nomenclature	MRGPRF
Other names	GPR168, GPR140, RTA, MGC21621, mrgF, MAS-related GPR, member F, MRGPRF, MRGF, G protein-coupled receptor 168, G protein-coupled receptor 140, Mas-related gene F protein, G-protein coupled receptor 168, G-protein coupled receptor 14, mas-related G protein-coupled MRGF, seven transmembrane helix receptor, G protein-coupled receptor MrgF, mas-related G-protein coupled receptor member F, LOC266762, G protein coupled receptor (RTA), G protein coupled receptor Rca, G-protein coupled receptor RTA, MAS-related G-protein coupled receptor, member F, MAS-related gene F, BC019711
IUPHAR-DB	MRGPRF
Genes	MRGPRF (Hs), Mrgprf (Mm), Mrgprf (Rn)
Ensembl ID	ENSG00000172935 (Hs), ENSMUSG00000031070 (Mm), ENSRNOG00000013426 (Rn)
Principal transduction	-

MRGPRG Show »« Hide

Nomenclature	MRGPRG
Other names	MAS-related GPR, member G, GPR169, mrgG, MRGG, EBRT2, MRGPRG, G protein-coupled receptor 169, G protein-coupled receptor Mrgg, MAS-related G-protein coupled receptor, member G, MAS-related gene G, mas-related G-protein coupled receptor member G, LOC381974, Gm1098
IUPHAR-DB	MRGPRG
Genes	MRGPRG (Hs), Mrgprg (Mm), Mrgprg (Rn)
Ensembl ID	ENSG00000182170 (Hs), ENSMUSG00000050276 (Mm), ENSRNOG00000020734 (Rn)
Principal transduction	-

MRGPRX1 Show »« Hide

Nomenclature

MRGPRX1

Other names

Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 1, Mrgc, Mrgprc, Mrgprc11, Snsr, Snsr1, MRGX1, SNSR3, SNSR4, Mrgprb2, MRGPRX1, G protein-coupled receptor MRGX1, G protein-coupled receptor SNSR3, MAS-related GPR, member X1, MrgX1

IUPHAR-DB

MRGPRX1

Genes

MRGPRX1 (Hs)

Ensembl ID

ENSG00000170255 (Hs)

Principal transduction

Endogenous agonists
(pK_i)

BAM8-22 (Selective) (pEC₅₀ 7.8) [11,44]

Comment

Reported to mediate the sensation of itch [50,85].

MRGPRX2 Show »« Hide

Nomenclature

MRGPRX2

Other names

MRGX2, Mrgprb10, MAS-related GPR, member X2, MrgX2

IUPHAR-DB

MRGPRX2

Genes

MRGPRX2 (Hs)

Ensembl ID

ENSG00000183695 (Hs)

Principal transduction

Endogenous agonists
(pK_i)

PAMP-20 (Selective) [36]

Selective agonists
(pK_i)

PAMP-12 (human) (pEC₅₀ 7.24 – 7.68) [36]

CST-14 {Sp: Mouse, Rat} (pEC₅₀ 7.31 – 7.6) [36,79]

Comment

Reportedly a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides (PAMP) [36].

MRGPRX3 Show »« Hide

Nomenclature	MRGPRX3
Other names	MrgA, Mrgpra, MRGX3, Mrga10, SNSR1, SNSR2, Sensory neuron-specific G protein-coupled receptor 1/2, MAS-related GPR, member X3
IUPHAR-DB	MRGPRX3
Genes	MRGPRX3 (Hs)
Ensembl ID	ENSG00000179826 (Hs)
Principal transduction	-

MRGPRX4 Show »« Hide

Nomenclature	MRGPRX4
Other names	MGC129753, MGC129754, MAS-related GPR, member X4, SNSR5, SNSR6, MRGX4, Sensory neuron-specific G protein-coupled receptor 5/6, Sensory neuron-specific G-protein coupled receptor 5/6, G protein-coupled receptor SNSR5, G protein-coupled receptor SNSR6, G protein-coupled receptor MRGX4, MRGPRX4
IUPHAR-DB	MRGPRX4
Genes	MRGPRX4 (Hs)
Ensembl ID	ENSG00000179817 (Hs)
Principal transduction	-

OPN3 Show »« Hide

Nomenclature	OPN3
Other names	Opsin-3, Encephalopsin, Panopsin, ECPN, ERO, NMO-1, LOC498289, opsin 3, similar to Opsin-3 (Encephalopsin) (Panopsin)
IUPHAR-DB	OPN3
Genes	OPN3 (Hs), Opn3 (Mm), Opn3 (Rn)
Ensembl ID	ENSG00000054277 (Hs), ENSMUSG00000026525 (Mm), ENSRNOG00000003778 (Rn)
Principal transduction	-

OPN5 Show »« Hide

Nomenclature	OPN5
Other names	opsin 5, transmembrane protein 13, neuropsin, dJ402H5.1, GPR136, PGR12, OPN5, PGR14, G-protein coupled receptor 136, Transmembrane protein 13, Neuropsin, opsin-5, G-protein coupled receptor PGR12, TMEM13, G protein-coupled receptor 136
IUPHAR-DB	OPN5
Genes	OPN5 (Hs), Opn5 (Mm), Opn5 (Rn)
Ensembl ID	ENSG00000124818 (Hs), ENSMUSG00000043972 (Mm), ENSRNOG00000012689 (Rn)
Principal transduction	-

P2RY8 Show »« Hide

Nomenclature	P2RY8
Other names	purinergic receptor P2Y, G-protein coupled, 8, P2Y8, MGC50878, P2RY8, G-protein coupled purinergic receptor P2Y8, purinergic receptor P2Y, G-protein coupled, 8, P2Y purinoceptor 8
IUPHAR-DB	P2RY8
Genes	P2RY8 (Hs)
Ensembl ID	ENSG00000182162 (Hs)
Principal transduction	-

P2RY10 Show »« Hide

Nomenclature

P2RY10

Other names

purinergic receptor P2Y, G-protein coupled, 10, P2Y-like receptor, P2Y10, purinergic receptor, P2Y-like, LOC317219, MGC189289, P2ry10_predicted, RGD1561912, RGD1561912_predicted, purinergic receptor P2Y, G-protein coupled 10 , purinergic receptor P2Y, G-protein coupled 10 (predicted), similar to purinergic receptor P2Y, G-protein coupled 10, similar to purinergic receptor P2Y, G-protein coupled 10 (predicted), 5830408N17Rik

IUPHAR-DB

P2RY10

Genes

P2RY10 (Hs), P2ry10 (Mm), P2ry10 (Rn)

Ensembl ID

ENSG00000078589 (Hs), ENSMUSG00000050921 (Mm), ENSRNOG00000037839 (Rn)

Principal transduction

Endogenous agonists
(pK_i)

sphingosine 1-phosphate (Selective) (pEC₅₀ 7.3) [65]

LPA (Selective) (pEC₅₀ 6.9) [65]

TAAR2 Show »« Hide

Nomenclature	TAAR2
Other names	GPR58, TA₂, trace amine associated receptor 2, TAA2, G protein-coupled receptor 58, Gpr58_predicted, LOC294121, Taar2, G protein-coupled receptor 58 (predicted), G-protein coupled receptor 58, taR-2, trace amine receptor 2, trace amine-associated receptor 2, Gm225
IUPHAR-DB	TAAR2
Genes	TAAR2 (Hs), Taar2 (Mm), Taar2 (Rn)
Ensembl ID	ENSG00000146378 (Hs), ENSMUSG00000059763 (Mm), ENSRNOG00000025951 (Rn)
Principal transduction	G_s
Rank order of potency	β-phenylethylamine > tryptamine [6]

TAAR3 Show »« Hide

Nomenclature	TAAR3
Other names	trace amine associated receptor 3, GPR57, G protein-coupled receptor 57, taR-3, trace amine receptor 3, trace amine-associated receptor 3
IUPHAR-DB	TAAR3
Genes	TAAR3 (Hs), Taar3 (Mm), Taar3 (Rn)
Ensembl ID	ENSG00000179073 (Hs), ENSMUSG00000069708 (Mm), ENSRNOG00000025982 (Rn)
Principal transduction	-

TAAR4P Show »« Hide

Nomenclature	TAAR4P
Other names	Ta2, taR-2, taR-4, trace amine receptor 2, trace amine receptor 4, trace amine-associated receptor 4, trace-amine-associated receptor 4, Gm226
IUPHAR-DB	TAAR4P
Genes	TAAR4P (Hs), Taar4 (Mm), Taar4 (Rn)
Ensembl ID	ENSMUSG00000069707 (Mm), ENSRNOG00000029877 (Rn)
Principal transduction	-

TAAR5 Show »« Hide

Nomenclature	TAAR5
Other names	Putative neurotransmitter receptor, PNR, MGC138414, MGC138416, RP11-295F4.5, TAAR5, Trace amine receptor, Trace amine receptor 5, trace amine-associated receptor 5, TaR-5, trace amine associated receptor 5, LOC215854, Gm227
IUPHAR-DB	TAAR5
Genes	TAAR5 (Hs), Taar5 (Mm), Taar5 (Rn)
Ensembl ID	ENSG00000135569 (Hs), ENSMUSG00000069706 (Mm), ENSRNOG00000039869 (Rn)
Principal transduction	-

TAAR6 Show »« Hide

Nomenclature	TAAR6
Other names	Trace amine-associated receptor 6, Trace amine receptor 4, TaR-4, TA4, TAR4, TRAR4, RP11-295F4.3, SCZD5, TAAR6, TA₄, taR-6, trace amine receptor 6, trace-amine-associated receptor 6, LOC215855, Gm228
IUPHAR-DB	TAAR6
Genes	TAAR6 (Hs), Taar6 (Mm), Taar6 (Rn)
Ensembl ID	ENSG00000146383 (Hs), ENSMUSG00000045111 (Mm), ENSRNOG00000016089 (Rn)
Principal transduction	-

TAAR8 Show »« Hide

Nomenclature	TAAR8
Other names	trace amine associated receptor 8, trace amine receptor 5, TA5, TAR5, GPR102, TRAR5, TA11, TAR11, TRAR11, Gm1149, taR-11, taR-8a, trace amine receptor 11, trace amine receptor 8a, trace amine-associated receptor 8a, trace-amine-associated receptor 8a, LOC215859, Gm230
IUPHAR-DB	TAAR8
Genes	TAAR8 (Hs), Taar8a (Mm), Taar8a (Rn)
Ensembl ID	ENSG00000146385 (Hs), ENSMUSG00000050804 (Mm), ENSRNOG00000030414 (Rn)
Principal transduction	-

TAAR9 Show »« Hide

Nomenclature	TAAR9
Other names	trace amine-associated receptor 9, TA3, TAR3, TRAR3, trace amine receptor 3, trace amine associated receptor 9, taR-3, taR-9, trace amine receptor 9, trace-amine-associated receptor 9, Gm231
IUPHAR-DB	TAAR9
Genes	TAAR9 (Hs), Taar9 (Mm), Taar9 (Rn)
Ensembl ID	ENSG00000237110 (Hs), ENSMUSG00000037424 (Mm), ENSRNOG00000026096 (Rn)
Principal transduction	-

Class B Orphans

More information on this family may be found on the IUPHAR-DB family and introduction pages.

Overview Show »« Hide

With the exception of GPR157, all Class B orphan receptors listed below are adhesion GPCRs.

Adhesion GPCRs
Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a "stalk" motif containing a GPCR proteolytic site. The N-terminus often shares structural homology with proteins such as lectins and immunoglobulins, leading to the term adhesion GPCR [22,103].

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Receptors

BAI1 Show »« Hide

Nomenclature

BAI1

Other names

brain-specific angiogenesis inhibitor 1, FLJ41988, BAI1, GDAIF, Bai1_predicted, LOC362931, brain-specific angiogenesis inhibitor 1 (predicted), B830018M07Rik, R75078

IUPHAR-DB

BAI1

Genes

BAI1 (Hs), Bai1 (Mm), Bai1 (Rn)

Ensembl ID

ENSG00000181790 (Hs), ENSMUSG00000034730 (Mm)

Principal transduction

Endogenous agonists
(pK_i)

phosphatidylserine [74]

Comment

BAI1 is reported to respond to phosphatidylserine [74].

BAI2 Show »« Hide

Nomenclature	BAI2
Other names	brain-specific angiogenesis inhibitor 2, BAI2, Bai2_predicted, LOC313058, brain-specific angiogenesis inhibitor 2 (predicted)
IUPHAR-DB	BAI2
Genes	BAI2 (Hs), Bai2 (Mm), Bai2 (Rn)
Ensembl ID	ENSG00000121753 (Hs), ENSMUSG00000028782 (Mm), ENSRNOG00000014375 (Rn)
Principal transduction	-

BAI3 Show »« Hide

Nomenclature	BAI3
Other names	brain-specific angiogenesis inhibitor 3, MGC133100, KIAA0550, BAI3, Bai3_predicted, LOC301309, brain-specific angiogenesis inhibitor 3 (predicted), A830096D10Rik
IUPHAR-DB	BAI3
Genes	BAI3 (Hs), Bai3 (Mm), Bai3 (Rn)
Ensembl ID	ENSG00000135298 (Hs), ENSMUSG00000033569 (Mm), ENSRNOG00000012045 (Rn)
Principal transduction	-

CD97 Show »« Hide

Nomenclature	CD97
Other names	CD97 molecule, CD97 antigen, EGF-TM7 receptor, TM7LN1, Leukocyte antigen CD97, seven-span transmembrane protein, seven-transmembrane, heterodimeric receptor associated with inflammation, seven transmembrane helix receptor, Cd97_predicted, LOC361383, CD97 antigen (predicted), AA409984
IUPHAR-DB	CD97
Genes	CD97 (Hs), Cd97 (Mm), Cd97 (Rn)
Ensembl ID	ENSG00000123146 (Hs), ENSMUSG00000002885 (Mm), ENSRNOG00000004489 (Rn)
Principal transduction	-

CELSR1 Show »« Hide

Nomenclature	CELSR1
Other names	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila), ME2, HFMI2, FMI2, CDHF9, Cadherin EGF LAG seven-pass G-type receptor 1, flamingo homologue 2, hFmi2, cadherin, EGF LAG seven-pass G-type receptor 1, flamingo (Drosophila) homolog, LOC300128, cadherin, EGF LAG seven-pass G-type receptor 1, flamingo-like protein celsr1, Scy, Crsh, crash
IUPHAR-DB	CELSR1
Genes	CELSR1 (Hs), Celsr1 (Mm), Celsr1 (Rn)
Ensembl ID	ENSG00000075275 (Hs), ENSMUSG00000016028 (Mm), ENSRNOG00000021285 (Rn)
Principal transduction	-

CELSR2 Show »« Hide

Nomenclature	CELSR2
Other names	CDHF10, EGFL2, FLJ34118, FLJ42737, FLJ45143, FLJ45845, Flamingo1, KIAA0279, MEGF3, EGF-like-domain, multiple 2, cadherin EGF LAG seven-pass G-type receptor 2, epidermal growth factor-like 2, multiple epidermal growth factor-like domains 3, flamingo 1, cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog, flamingo-like protein celsr2, multiple EGF-like domains protein 3, multiple epidermal growth factor-like domains protein 3, seven-pass transmembrane cadherin, mfmi1
IUPHAR-DB	CELSR2
Genes	CELSR2 (Hs), Celsr2 (Mm), Celsr2 (Rn)
Ensembl ID	ENSG00000143126 (Hs), ENSMUSG00000068740 (Mm), ENSRNOG00000020058 (Rn)
Principal transduction	-

CELSR3 Show »« Hide

Nomenclature	CELSR3
Other names	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila), CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, Cadherin EGF LAG seven-pass G-type receptor 3, flamingo 1, hFmi1, multiple epidermal growth factor-like domains 2, epidermal growth factor-like 1, flamingo homolog 1, cadherin EGF LAG seven-pass G-type receptor 3, flamingo (Drosophila) homolog, multiple EGF-like domains protein 2, multiple epidermal growth factor-like domains protein 2, flamingo
IUPHAR-DB	CELSR3
Genes	CELSR3 (Hs), Celsr3 (Mm), Celsr3 (Rn)
Ensembl ID	ENSG00000008300 (Hs), ENSMUSG00000023473 (Mm), ENSRNOG00000034005 (Rn)
Principal transduction	-

ELTD1 Show »« Hide

Nomenclature	ELTD1
Other names	EGF, latrophilin seven transmembrane domain containing 1, ETL protein, KPG_003, EGF-TM7-latrophilin-related protein, ETL, EGF, latrophilin and seven transmembrane domain-containing protein 1, EGF, latrophilin and seven transmembrane domain containing 1, EGF, latrophilin and seven transmembrane domain-containing protein 1, EGF-TM7 receptor, 1110033N21Rik
IUPHAR-DB	ELTD1
Genes	ELTD1 (Hs), Eltd1 (Mm), Eltd1 (Rn)
Ensembl ID	ENSG00000162618 (Hs), ENSMUSG00000039167 (Mm), ENSRNOG00000033940 (Rn)
Principal transduction	-

EMR1 Show »« Hide

Nomenclature	EMR1
Other names	TM7LN3, EGF-like module containing, mucin-like, hormone receptor-like sequence 1, DD7A5-7, F4/80, Ly71, EGF-like module-containing mucin-like hormone receptor-like 1, cell surface glycoprotein EMR1, EMR1 hormone receptor, EGF-like module containing, mucin-like, hormone receptor-like 1, EGF-like module receptor 1, EGF-TM7, Gpf480
IUPHAR-DB	EMR1
Genes	EMR1 (Hs), Emr1 (Mm), Emr1 (Rn)
Ensembl ID	ENSG00000174837 (Hs), ENSMUSG00000004730 (Mm)
Principal transduction	-

EMR2 Show »« Hide

Nomenclature	EMR2
Other names	egf-like module containing, mucin-like, hormone receptor-like 2, CD312, EGF-like module-containing mucin-like hormone receptor-like 2, EGF-like module EMR2, CD312 antigen, egf-like module containing, mucin-like, hormone receptor-like sequence 2
IUPHAR-DB	EMR2
Genes	EMR2 (Hs)
Ensembl ID	ENSG00000127507 (Hs)
Principal transduction	-

EMR3 Show »« Hide

Nomenclature	EMR3
Other names	egf-like module containing, mucin-like, hormone receptor-like 3, EGF-like module-containing mucin-like hormone receptor-like 3, EGF-like module-containing mucin-like receptor EMR3
IUPHAR-DB	EMR3
Genes	EMR3 (Hs)
Ensembl ID	ENSG00000131355 (Hs)
Principal transduction	-

GPR56 Show »« Hide

Nomenclature	GPR56
Other names	BFPP, DKFZp781L1398, TM7LN4, TM7XN1, G-protein coupled receptor 56, Cyt28
IUPHAR-DB	GPR56
Genes	GPR56 (Hs), Gpr56 (Mm), Gpr56 (Rn)
Ensembl ID	ENSG00000205336 (Hs), ENSMUSG00000031785 (Mm)
Principal transduction	-
Comment	Reported to bind tissue transglutaminase 2 [99] and collagen, which activates the G_12/13 pathway [55].

GPR64 Show »« Hide

Nomenclature	GPR64
Other names	CTD-2245E12.1, FLJ00282, HE6, MGC104454, MGC138738, MGC138739, TM7LN2, EDDM6, epididymal protein 6, Re6, G protein-coupled receptor 64, G-protein coupled receptor 64, epididymis-specific protein 6, re6 receptor, Me6, AW212196, B830041D06Rik
IUPHAR-DB	GPR64
Genes	GPR64 (Hs), Gpr64 (Mm), Gpr64 (Rn)
Ensembl ID	ENSG00000173698 (Hs), ENSMUSG00000031298 (Mm), ENSRNOG00000032472 (Rn)
Principal transduction	-

GPR97 Show »« Hide

Nomenclature	GPR97
Other names	PGR26, Pb99, GPR-97, PB99, EGF-TM7-like, GPR97, G-protein coupled receptor 97, G-protein coupled receptor PGR26, probable G-protein coupled receptor 97, Gpr97_predicted, LOC291854, G protein-coupled receptor 97, G protein-coupled receptor 97 (predicted), A030001G24Rik, AW214383
IUPHAR-DB	GPR97
Genes	GPR97 (Hs), Gpr97 (Mm), Gpr97 (Rn)
Ensembl ID	ENSG00000182885 (Hs), ENSMUSG00000060470 (Mm), ENSRNOG00000014896 (Rn)
Principal transduction	-

GPR98 Show »« Hide

Nomenclature	GPR98
Other names	DKFZp761P0710, GPR98, USH2B, VLGR1, VLGR1b, FEB4, KIAA0686, MASS1, USH2C, Frings, monogenic audiogenic seizure susceptibility 1 homolog, monogenic, audiogenic seizure susceptibility 1 homolog (mouse), LOC362068, LOC685383, G protein-coupled receptor 98, neurepin, similar to monogenic, audiogenic seizure susceptibility 1, very large G protein-coupled receptor 1, Mgr1
IUPHAR-DB	GPR98
Genes	GPR98 (Hs), Gpr98 (Mm), Gpr98 (Rn)
Ensembl ID	ENSG00000164199 (Hs), ENSMUSG00000069170 (Mm)
Principal transduction	-
Comment	Loss-of-function mutations are associated with Usher syndrome, a sensory deficit disorder [32].

GPR110 Show »« Hide

Nomenclature	GPR110
Other names	PGR19, KPG_012, hGPCR36, FLJ22684, FLJ30646, MGC125952, Gpr110_predicted, LOC301266, G protein-coupled receptor 110, G protein-coupled receptor 110 (predicted), 5031409J19Rik
IUPHAR-DB	GPR110
Genes	GPR110 (Hs), Gpr110 (Mm), Gpr110 (Rn)
Ensembl ID	ENSG00000153292 (Hs), ENSMUSG00000041293 (Mm), ENSRNOG00000025654 (Rn)
Principal transduction	-

GPR111 Show »« Hide

Nomenclature	GPR111
Other names	PGR20, hGPCR35, FLJ44729, Gpr115_predicted, Gpr115, LOC301269, G protein-coupled receptor 111, G protein-coupled receptor 115, G protein-coupled receptor 115 (predicted), probable G-protein coupled receptor 111
IUPHAR-DB	GPR111
Genes	GPR111 (Hs), Gpr111 (Mm), Gpr111 (Rn)
Ensembl ID	ENSG00000164393 (Hs), ENSMUSG00000057899 (Mm), ENSRNOG00000025603 (Rn)
Principal transduction	-

GPR112 Show »« Hide

Nomenclature	GPR112
Other names	RP1-299I16, PGR17, DKFZp781E1948, RGD1564057, RP11-51D15.1, Gpr112, LOC688451, G protein-coupled receptor 112, similar to G-protein coupled receptor 112, LOC236798, Gm367
IUPHAR-DB	GPR112
Genes	GPR112 (Hs), Gpr112 (Mm), Gpr112l (Rn)
Ensembl ID	ENSG00000156920 (Hs), ENSMUSG00000053852 (Mm)
Principal transduction	-

GPR113 Show »« Hide

Nomenclature	GPR113
Other names	FLJ16767, PGR23, hGPCR37, Gpr113_predicted, LOC298857, G protein-coupled receptor 113, G protein-coupled receptor 113 (predicted), probable G-protein coupled receptor 113, LOC381628, Gm1041
IUPHAR-DB	GPR113
Genes	GPR113 (Hs), Gpr113 (Mm), Gpr113 (Rn)
Ensembl ID	ENSG00000173567 (Hs), ENSMUSG00000067642 (Mm), ENSRNOG00000024766 (Rn)
Principal transduction	-

GPR114 Show »« Hide

Nomenclature	GPR114
Other names	PGR27, Gpr114_predicted, LOC307645, G protein-coupled receptor 114, G protein-coupled receptor 114 (predicted), G protein-coupled receptor 114-like, probable G-protein coupled receptor 114, LOC382045, Gm1109
IUPHAR-DB	GPR114
Genes	GPR114 (Hs), Gpr114 (Mm), Gpr114 (Rn)
Ensembl ID	ENSG00000159618 (Hs), ENSMUSG00000061577 (Mm), ENSRNOG00000039891 (Rn)
Principal transduction	-

GPR115 Show »« Hide

Nomenclature	GPR115
Other names	FLJ38076, PGR18, LOC501106, RGD1565216, RGD1565216_predicted, G protein-coupled receptor 115, similar to G-protein coupled receptor 115, similar to G-protein coupled receptor 115 (predicted), 4632435A09Rik, AV239010
IUPHAR-DB	GPR115
Genes	GPR115 (Hs), Gpr115 (Mm), Gpr115 (Rn)
Ensembl ID	ENSG00000153294 (Hs), ENSMUSG00000023918 (Mm)
Principal transduction	-

GPR116 Show »« Hide

Nomenclature	GPR116
Other names	DKFZp564O1923, FLJ90640, KIAA0758, KPG_001, Ig-Hepta homolog, Gprhep, Ig-Hepta, G protein-coupled hepta-helical receptor Ig-Hepta, G protein-coupled receptor 116, G-protein coupled hepta-helical receptor Ig-hepta, probable G-protein coupled receptor 116, 8430401C09Rik, AI528491
IUPHAR-DB	GPR116
Genes	GPR116 (Hs), Gpr116 (Mm), Gpr116 (Rn)
Ensembl ID	ENSG00000069122 (Hs), ENSMUSG00000056492 (Mm), ENSRNOG00000011154 (Rn)
Principal transduction	-

GPR123 Show »« Hide

Nomenclature	GPR123
Other names	KIAA1828, D7Ertd680e, GPR123, G-protein coupled receptor 123, probable G-protein coupled receptor 123, Gpr123_predicted, LOC309097, G protein-coupled receptor 123, G protein-coupled receptor 123 (predicted), 2900059M17Rik
IUPHAR-DB	GPR123
Genes	GPR123 (Hs), Gpr123 (Mm), Gpr123 (Rn)
Ensembl ID	ENSG00000197177 (Hs), ENSMUSG00000025475 (Mm), ENSRNOG00000033646 (Rn)
Principal transduction	-

GPR124 Show »« Hide

Nomenclature	GPR124
Other names	KIAA1531, TEM5, DKFZp434C211, DKFZp434J0911, FLJ14390, Tumour endothelial marker 5, tumor endothelial marker 5, Gpr124_predicted, LOC306543, G protein-coupled receptor 124 (predicted), 8430414O08Rik, 9530074E10Rik
IUPHAR-DB	GPR124
Genes	GPR124 (Hs), Gpr124 (Mm), Gpr124 (Rn)
Ensembl ID	ENSG00000020181 (Hs), ENSMUSG00000031486 (Mm)
Principal transduction	-

GPR125 Show »« Hide

Nomenclature	GPR125
Other names	FLJ38547, PGR21, TEM5-like, TEM5L, Gpr125_predicted, LOC305408, G protein-coupled receptor 125, G protein-coupled receptor 125 (predicted), probable G-protein coupled receptor 125, 3830613O22Rik, AU044632
IUPHAR-DB	GPR125
Genes	GPR125 (Hs), Gpr125 (Mm), Gpr125 (Rn)
Ensembl ID	ENSG00000152990 (Hs), ENSMUSG00000029090 (Mm)
Principal transduction	-

GPR126 Show »« Hide

Nomenclature	GPR126
Other names	FLJ14937, DREG, OTTHUMP00000040178, PS1TP2, VIGR, HBV PreS1-transactivated protein 2, Gpr126_predicted, LOC308376, G protein-coupled receptor 126, G protein-coupled receptor 126 (predicted), G-protein coupled receptor 126, LOC215798, 1190004A11Rik, AI449247, AW045736, Gm222
IUPHAR-DB	GPR126
Genes	GPR126 (Hs), Gpr126 (Mm), Gpr126 (Rn)
Ensembl ID	ENSG00000112414 (Hs), ENSMUSG00000039116 (Mm)
Principal transduction	-

GPR128 Show »« Hide

Nomenclature	GPR128
Other names	FLJ14454, FLJ16382, FLJ29035, MGC142011, MGC163260, Gpr128_predicted, LOC304014, G protein-coupled receptor 128, G protein-coupled receptor 128 (predicted), probable G-protein coupled receptor 128, 9130020O16Rik
IUPHAR-DB	GPR128
Genes	GPR128 (Hs), Gpr128 (Mm), Gpr128 (Rn)
Ensembl ID	ENSG00000144820 (Hs), ENSMUSG00000022755 (Mm), ENSRNOG00000001634 (Rn)
Principal transduction	-

GPR133 Show »« Hide

Nomenclature	GPR133
Other names	DKFZp434B1272, PGR25, FLJ16770, MGC138512, MGC138514, E230012M21Rik
IUPHAR-DB	GPR133
Genes	GPR133 (Hs), Gpr133 (Mm)
Ensembl ID	ENSG00000111452 (Hs), ENSMUSG00000044017 (Mm)
Principal transduction	-

GPR144 Show »« Hide

GPR157 Show »« Hide

Nomenclature	GPR157
Other names	FLJ12132, MGC109533, GPR157, G-protein coupled receptor 157, probable G-protein coupled receptor 157, Gpr157_predicted, LOC313725, G protein-coupled receptor 157, G protein-coupled receptor 157 (predicted), F730108M23Rik
IUPHAR-DB	GPR157
Genes	GPR157 (Hs), Gpr157 (Mm), Gpr157 (Rn)
Ensembl ID	ENSG00000180758 (Hs), ENSMUSG00000047875 (Mm), ENSRNOG00000017528 (Rn)
Principal transduction	-

LPHN1 Show »« Hide

Nomenclature	LPHN1
Other names	KIAA0821, CIRL1, latrophilin 1, lectomedin-2, CL1, LEC2, Latrophilin-1, calcium-independent α-latrotoxin receptor 1, CL1BA, CIRL-1, CL1BA protein, calcium-independent alpha-latrotoxin receptor 1, 2900070I05Rik, AI182398
IUPHAR-DB	LPHN1
Genes	LPHN1 (Hs), Lphn1 (Mm), Lphn1 (Rn)
Ensembl ID	ENSG00000072071 (Hs), ENSMUSG00000013033 (Mm), ENSRNOG00000029134 (Rn)
Principal transduction	-

LPHN2 Show »« Hide

Nomenclature	LPHN2
Other names	KIAA0786, latrophilin 2, Lec1, Lphh1, lectomedin-1, CL2, LEC1, Latrophilin-2, calcium-independent α-latrotoxin receptor 2, latrophilin homologue 1, latrophilin 1, Cirl-2, Cirl2, Cl2ac, calcium-independent alpha-latrotoxin receptor 2, calcium-independent alpha-latrotoxin receptor homolog 2, AI450192
IUPHAR-DB	LPHN2
Genes	LPHN2 (Hs), Lphn2 (Mm), Lphn2 (Rn)
Ensembl ID	ENSG00000117114 (Hs), ENSMUSG00000028184 (Mm), ENSRNOG00000032660 (Rn)
Principal transduction	-

LPHN3 Show »« Hide

Nomenclature	LPHN3
Other names	KIAA0768, latrophilin 3, Lectomedin-3, CIRL3, calcium-independent alpha-latrotoxin receptor homolog 3, LEC3, Latrophilin-3, calcium-independent α-latrotoxin receptor 3, lectomedin-3, CIRL-3, lectomedin 3, 5430402I23Rik, D130075K09Rik
IUPHAR-DB	LPHN3
Genes	LPHN3 (Hs), Lphn3 (Mm), Lphn3 (Rn)
Ensembl ID	ENSG00000150471 (Hs), ENSMUSG00000037605 (Mm), ENSRNOG00000030149 (Rn)
Principal transduction	-

Class C Orphans

More information on this family may be found on the IUPHAR-DB family and introduction pages.

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Receptors

GPR156 Show »« Hide

Nomenclature	GPR156
Other names	ZK180.1-like, MGC142261, PGR28, DEPDC3, DEP.7, FLJ31819, PGR22, GABABL, G protein-coupled receptor 156, GABAB-related G-protein coupled receptor, probable G-protein coupled receptor 156
IUPHAR-DB	GPR156
Genes	GPR156 (Hs), Gpr156 (Mm), Gpr156 (Rn)
Ensembl ID	ENSG00000175697 (Hs), ENSMUSG00000046961 (Mm), ENSRNOG00000002797 (Rn)
Principal transduction	-

GPR158 Show »« Hide

Nomenclature	GPR158
Other names	KIAA1136, FLJ37801, RP11-59G22.1, FLJ12132, Gpr158_predicted, LOC291352, G protein-coupled receptor 158, G protein-coupled receptor 158 (predicted), probable G-protein coupled receptor 158, 5330427M13Rik
IUPHAR-DB	GPR158
Genes	GPR158 (Hs), Gpr158 (Mm), Gpr158 (Rn)
Ensembl ID	ENSG00000151025 (Hs), ENSMUSG00000045967 (Mm), ENSRNOG00000024832 (Rn)
Principal transduction	-

GPR179 Show »« Hide

Nomenclature	GPR179
Other names	GPR158L1, GPR158-like 1, GPR179, LOC287657, RGD1560033, RGD1560033_predicted, G protein-coupled receptor 179, similar to GPR158-like 1, similar to GPR158-like 1 (predicted), 5330439C02Rik
IUPHAR-DB	GPR179
Genes	GPR179 (Hs), Gpr179 (Mm), Gpr179 (Rn)
Ensembl ID	ENSG00000188888 (Hs), ENSMUSG00000070337 (Mm)
Principal transduction	-

GPRC5A Show »« Hide

Nomenclature	GPRC5A
Other names	RAIG1, Gprc5a, retinoic acid induced 3, RAIG₁, Retinoic acid-induced protein 3, G protein-coupled receptor family C group 5 member A, retinoic acid-induced gene 1 protein, RAIG-1, orphan G protein-coupling receptor PEIG-1, RAI3, GPCR5A, LOC312790, MGC156777, Rai3_predicted, G protein-coupled receptor, family C, group 5, member A, retinoic acid induced 3 (predicted)
IUPHAR-DB	GPRC5A
Genes	GPRC5A (Hs), Gprc5a (Mm), Gprc5a (Rn)
Ensembl ID	ENSG00000013588 (Hs), ENSMUSG00000046733 (Mm), ENSRNOG00000008412 (Rn)
Principal transduction	-

GPRC5B Show »« Hide

Nomenclature	GPRC5B
Other names	RAIG-2, RAIG₂, G protein-coupled receptor family C group 5 member B, retinoic acid-induced gene 2 protein, A-69G12.1, G protein-coupled receptor, family C, group 1, member B, Gprc5b_predicted, LOC293546, G protein-coupled receptor, family C, group 5, member B, G protein-coupled receptor, family C, group 5, member B (predicted), G-protein coupled receptor family C group 5 member B, hypothetical protein, clone 2-63, AW125761
IUPHAR-DB	GPRC5B
Genes	GPRC5B (Hs), Gprc5b (Mm), Gprc5b (Rn)
Ensembl ID	ENSG00000167191 (Hs), ENSMUSG00000008734 (Mm), ENSRNOG00000016013 (Rn)
Principal transduction	-

CCRL2	GPR17	GPR37	GPR84	GPR161	MRGPRX1
GPR1	GPR20	GRP39	GPR87	GPR183	MRGPRX2
GPR3	GPR22	GPR50	GPR88	LGR4	P2RY10
GRP4	GPR26	GPR63	GPR120	LGR5	OXGR1
GPR6	GPR31	GPR65	GPR132	LGR6	SUCNR1
GPR12	GPR34	GPR68	GPR143	MAS1	TAAR2
GPR15	GPR35	GPR75	GPR149	MRGPRD