Orphan and other 7TM receptors | G protein-coupled receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Orphan and other 7TM receptors

Orphan and other 7TM receptors C

Contents

Subfamilies
Further reading
How to cite this family page

Subfamilies

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Class A Orphans C Class B Orphans Class C Orphans C Opsin receptors Taste 1 receptors C Taste 2 receptors C Other 7TM proteins C

Further reading

* Key recommended reading is highlighted with an asterisk

Andres-Barquin PJ, Conte C. (2004) Molecular basis of bitter taste: the T2R family of G protein-coupled receptors. Cell Biochem. Biophys., 41 (1): 99-112. [PMID:15371642]

Bachmanov AA, Beauchamp GK. (2007) Taste receptor genes. Annu. Rev. Nutr., 27: 389-414. [PMID:17444812]

* Blaho VA, Hla T. (2011) Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem. Rev., 111 (10): 6299-320. [PMID:21939239]

* Chi H. (2011) Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol. Sci., 32 (1): 16-24. [PMID:21159389]

* Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. (2010) International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol. Rev., 62 (4): 579-87. [PMID:21079037]

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. (2000) International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev., 52: 415-472. [PMID:10977869]

DeSimone JA, Lyall V. (2006) Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue. Am. J. Physiol. Gastrointest. Liver Physiol., 291 (6): G1005-10. [PMID:16809639]

Ellis B, Li XC, Miguel-Qin E, Gu V, Zhuo JL. (2012) Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol., 302 (5): R494-509. [PMID:22170616]

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]

Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol, 63: 1256-1272. [PMID:12761335]

Kinnamon SC. (2012) Taste receptor signalling - from tongues to lungs. Acta Physiol (Oxf), 204 (2): 158-68. [PMID:21481196]

Lagerström MC, Schiöth HB. (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov, 7 (4): 339-57. [PMID:18382464]

* Maceyka M, Harikumar KB, Milstien S, Spiegel S. (2012) Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol., 22 (1): 50-60. [PMID:22001186]

MacKenzie A. (2011) Endothelium-derived vasoactive agents, AT1 receptors and inflammation. Pharmacol. Ther., 131 (2): 187-203. [PMID:21115037]

Meyerhof W. (2005) Elucidation of mammalian bitter taste. Rev. Physiol. Biochem. Pharmacol., 154: 37-72. [PMID:16032395]

* Mutoh T, Rivera R, Chun J. (2012) Insights into the pharmacological relevance of lysophospholipid receptors. Br. J. Pharmacol., 165 (4): 829-44. [PMID:21838759]

* O'Sullivan C, Dev KK. (2013) The structure and function of the S1P1 receptor. Trends Pharmacol. Sci., 34 (7): 401-12. [PMID:23763867]

Overington JP, Al-Lazikani B, Hopkins AL. (2006) How many drug targets are there?. Nat Rev Drug Discov, 5 (12): 993-6. [PMID:17139284]

Patel BM, Mehta AA. (2012) Aldosterone and angiotensin: Role in diabetes and cardiovascular diseases. Eur. J. Pharmacol., 697 (1-3): 1-12. [PMID:23041273]

Putnam K, Shoemaker R, Yiannikouris F, Cassis LA. (2012) The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome. Am. J. Physiol. Heart Circ. Physiol., 302 (6): H1219-30. [PMID:22227126]

* Pyne S, Pyne NJ. (2011) Translational aspects of sphingosine 1-phosphate biology. Trends Mol Med, 17 (8): 463-72. [PMID:21514226]

Renwick AG, Molinary SV. (2010) Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release. Br. J. Nutr., 104 (10): 1415-20. [PMID:20619074]

Ross RA. (2009) The enigmatic pharmacology of GPR55. Trends Pharmacol. Sci., 30 (3): 156-63. [PMID:19233486]

Rozengurt E. (2006) Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am. J. Physiol. Gastrointest. Liver Physiol., 291 (2): G171-7. [PMID:16710053]

Rozengurt E, Sternini C. (2007) Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol, 7 (6): 557-62. [PMID:18024184]

Sevá Pessôa B, van der Lubbe N, Verdonk K, Roks AJ, Hoorn EJ, Danser AH. (2013) Key developments in renin-angiotensin-aldosterone system inhibition. Nat Rev Nephrol, 9 (1): 26-36. [PMID:23165302]

* Spiegel S, Milstien S. (2011) The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol., 11 (6): 403-15. [PMID:21546914]

Temussi PA. (2009) Sweet, bitter and umami receptors: a complex relationship. Trends Biochem. Sci., 34 (6): 296-302. [PMID:19443222]

Tepper BJ. (2008) Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu. Rev. Nutr., 28: 367-88. [PMID:18407743]

Yarmolinsky DA, Zuker CS, Ryba NJ. (2009) Common sense about taste: from mammals to insects. Cell, 139 (2): 234-44. [PMID:19837029]

Yona S, Lin HH, Siu WO, Gordon S, Stacey M. (2008) Adhesion-GPCRs: emerging roles for novel receptors. Trends Biochem. Sci., 33 (10): 491-500. [PMID:18789697]

How to cite this family page

Database page citation:

Orphan and other 7TM receptors. Accessed on 26/05/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=115.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.