Orphan and other 7TM receptors | G protein-coupled receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Orphan and other 7TM receptors

Orphan and other 7TM receptors C

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Subfamilies
Further reading
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Subfamilies

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Further reading

* Key recommended reading is highlighted with an asterisk

Andres-Barquin PJ, Conte C. (2004) Molecular basis of bitter taste: the T2R family of G protein-coupled receptors. Cell Biochem. Biophys., 41 (1): 99-112. [PMID:15371642]

Bachmanov AA, Beauchamp GK. (2007) Taste receptor genes. Annu. Rev. Nutr., 27: 389-414. [PMID:17444812]

* Blaho VA, Hla T. (2011) Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem. Rev., 111 (10): 6299-320. [PMID:21939239]

* Chi H. (2011) Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol. Sci., 32 (1): 16-24. [PMID:21159389]

* Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. (2010) International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol. Rev., 62 (4): 579-87. [PMID:21079037]

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. (2000) International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev., 52: 415-472. [PMID:10977869]

DeSimone JA, Lyall V. (2006) Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue. Am. J. Physiol. Gastrointest. Liver Physiol., 291 (6): G1005-10. [PMID:16809639]

Ellis B, Li XC, Miguel-Qin E, Gu V, Zhuo JL. (2012) Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol., 302 (5): R494-509. [PMID:22170616]

Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]

Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol, 63: 1256-1272. [PMID:12761335]

Kinnamon SC. (2011) Taste receptor signalling - from tongues to lungs. Acta Physiol (Oxf), [Epub ahead of print]. [PMID:21481196]

Lagerström MC, Schiöth HB. (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov, 7 (4): 339-57. [PMID:18382464]

* Maceyka M, Harikumar KB, Milstien S, Spiegel S. (2012) Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol., 22 (1): 50-60. [PMID:22001186]

MacKenzie A. (2011) Endothelium-derived vasoactive agents, AT1 receptors and inflammation. Pharmacol. Ther., 131 (2): 187-203. [PMID:21115037]

Meyerhof W. (2005) Elucidation of mammalian bitter taste. Rev. Physiol. Biochem. Pharmacol., 154: 37-72. [PMID:16032395]

* Mutoh T, Rivera R, Chun J. (2012) Insights into the pharmacological relevance of lysophospholipid receptors. Br. J. Pharmacol., 165 (4): 829-44. [PMID:21838759]

* O'Sullivan C, Dev KK. (2013) The structure and function of the S1P1 receptor. Trends Pharmacol. Sci., 34 (7): 401-12. [PMID:23763867]

Overington JP, Al-Lazikani B, Hopkins AL. (2006) How many drug targets are there?. Nat Rev Drug Discov, 5 (12): 993-6. [PMID:17139284]

Patel BM, Mehta AA. (2012) Aldosterone and angiotensin: Role in diabetes and cardiovascular diseases. Eur. J. Pharmacol., 697 (1-3): 1-12. [PMID:23041273]

Putnam K, Shoemaker R, Yiannikouris F, Cassis LA. (2012) The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome. Am. J. Physiol. Heart Circ. Physiol., 302 (6): H1219-30. [PMID:22227126]

* Pyne S, Pyne NJ. (2011) Translational aspects of sphingosine 1-phosphate biology. Trends Mol Med, 17 (8): 463-72. [PMID:21514226]

Renwick AG, Molinary SV. (2010) Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release. Br. J. Nutr., 104 (10): 1415-20. [PMID:20619074]

Ross RA. (2009) The enigmatic pharmacology of GPR55. Trends Pharmacol. Sci., 30 (3): 156-63. [PMID:19233486]

Rozengurt E. (2006) Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am. J. Physiol. Gastrointest. Liver Physiol., 291 (2): G171-7. [PMID:16710053]

Rozengurt E, Sternini C. (2007) Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol, 7 (6): 557-62. [PMID:18024184]

Sevá Pessôa B, van der Lubbe N, Verdonk K, Roks AJ, Hoorn EJ, Danser AH. (2013) Key developments in renin-angiotensin-aldosterone system inhibition. Nat Rev Nephrol, 9 (1): 26-36. [PMID:23165302]

* Spiegel S, Milstien S. (2011) The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol., 11 (6): 403-15. [PMID:21546914]

Temussi PA. (2009) Sweet, bitter and umami receptors: a complex relationship. Trends Biochem. Sci., 34 (6): 296-302. [PMID:19443222]

Tepper BJ. (2008) Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu. Rev. Nutr., 28: 367-88. [PMID:18407743]

Yarmolinsky DA, Zuker CS, Ryba NJ. (2009) Common sense about taste: from mammals to insects. Cell, 139 (2): 234-44. [PMID:19837029]

Yona S, Lin HH, Siu WO, Gordon S, Stacey M. (2008) Adhesion-GPCRs: emerging roles for novel receptors. Trends Biochem. Sci., 33 (10): 491-500. [PMID:18789697]

How to cite this family page

Database page citation:

Orphan and other 7TM receptors. Accessed on 24/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=115.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.