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BB3 receptor
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GPR1
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| Nomenclature |
GPR1
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| Previous and unofficial names |
GPR1,
G-protein coupled receptor 1,
probable G-protein coupled receptor 1,
G protein-coupled receptor 1
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| Genes |
GPR1 (Hs), Gpr1 (Mm), Gpr1 (Rn) |
| Ensembl ID |
ENSG00000183671 (Hs), ENSMUSG00000046856 (Mm), ENSRNOG00000045532 (Rn)
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| UniProtKB AC |
P46091 (Hs), Q8K087 (Mm), P46090 (Rn)
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| Principal transduction |
-
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| Endogenous agonists |
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| Comment |
Reported to act as a co-receptor for HIV [106].
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GPR3
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| Nomenclature |
GPR3
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| Previous and unofficial names |
GPCR3,
Gpcr21,
ACCA,
GPR3,
G-protein coupled receptor 3,
ACCA orphan receptor,
adenylate cyclase constitutive activator,
G protein-coupled receptor 3,
G protein-coupled receptor R4,
G-protein-coupled receptor R4,
Gpcr20
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| Genes |
GPR3 (Hs), Gpr3 (Mm), Gpr3 (Rn) |
| Ensembl ID |
ENSG00000181773 (Hs), ENSMUSG00000049649 (Mm), ENSRNOG00000009540 (Rn)
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| UniProtKB AC |
P46089 (Hs), P35413 (Mm), Q8K1Q3 (Rn)
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| Principal transduction |
Gs
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| Comment |
sphingosine 1-phosphate was reported to be an endogenous agonist [117], but this finding was not replicated in subsequent studies [128]. Reported to activate adenylyl cyclase constitutively through Gs [25]. Gene disruption results in premature ovarian aging [64], reduced β-amyloid deposition [116] and hypersensitivity to thermal pain [101] in mice.
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GPR4
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| Nomenclature |
GPR4
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| Previous and unofficial names |
MGC116369,
GPR4,
G-protein coupled receptor 4,
G-protein coupled receptor 19,
GPR19,
Gpr4_predicted,
LOC308408,
G protein-coupled receptor 4,
G protein-coupled receptor 4 (predicted)
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| Genes |
GPR4 (Hs), Gpr4 (Mm), Gpr4 (Rn) |
| Ensembl ID |
ENSG00000177464 (Hs), ENSMUSG00000044317 (Mm), ENSRNOG00000016362 (Rn)
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| UniProtKB AC |
P46093 (Hs), Q8BUD0 (Mm), Q4KLH9 (Rn)
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| Principal transduction |
Gs
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Endogenous ligand
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Protons
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| Comment |
An initial report suggesting activation by lysophosphatidylcholine and sphingosylphosphorylcholine [134] has been retracted [135]. GPR4, GPR65, GPR68 and GPR132 are now thought to function as protein-sensing receptors detecting acidic pH [20,105]. Gene disruption is associated with increased perinatal mortality and impaired vascular proliferation [126].
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GPR6
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| Nomenclature |
GPR6
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| Previous and unofficial names |
Sphingosine 1-phosphate receptor GPR6,
GPR6,
G-protein coupled receptor 6,
Sphingosine 1-phosphate receptor,
G protein-coupled receptor 6,
putative G protein-coupled receptor (CNL3),
AI852874,
Gm233
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| Genes |
GPR6 (Hs), Gpr6 (Mm), Gpr6 (Rn) |
| Ensembl ID |
ENSG00000146360 (Hs), ENSMUSG00000046922 (Mm), ENSRNOG00000049580 (Rn)
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| UniProtKB AC |
P46095 (Hs), Q6YNI2 (Mm), P51651 (Rn)
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| Principal transduction |
Gs
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| Comment |
An initial report that sphingosine 1-phosphate (S1P) was a high-affinity ligand (EC50 value of 39nM) [42,117] was not repeated by β-Arrestin PathHunter[TM] assays [110,128]. Reported to activate adenylyl cyclase constitutively through Gs and to be located intracellularly [93]. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selected alterations in instrumental conditioning in vitro. [72].
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GPR12
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| Nomenclature |
GPR12
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| Previous and unofficial names |
MGC156481,
Gpcr12,
Gpcr01,
Gpcr20,
GPCR21,
GPR12,
G-protein coupled receptor 12,
GPCR12,
R334
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| Genes |
GPR12 (Hs), Gpr12 (Mm), Gpr12 (Rn) |
| Ensembl ID |
ENSG00000132975 (Hs), ENSMUSG00000041468 (Mm), ENSRNOG00000039832 (Rn)
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| UniProtKB AC |
P47775 (Hs), P35412 (Mm), P30951 (Rn)
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| Principal transduction |
-
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| Comment |
Reports that sphingosine 1-phosphate was a ligand of GPR12 [41,117] have not been replicated in β-arrestin-based assays [110,128]. Gene disruption results in dyslipidemia and obesity [7].
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GPR15
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| Nomenclature |
GPR15
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| Previous and unofficial names |
BOB,
GPR15,
G protein-coupled receptor 15,
Brother of Bonzo,
G-protein coupled receptor 15,
Gpr15_predicted,
LOC288181,
G protein-coupled receptor 15 (predicted),
4933439K08Rik,
BoB
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| Genes |
GPR15 (Hs), Gpr15 (Mm), Gpr15 (Rn) |
| Ensembl ID |
ENSG00000154165 (Hs), ENSMUSG00000047293 (Mm), ENSRNOG00000039680 (Rn)
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| UniProtKB AC |
P49685 (Hs), Q0VDU3 (Mm)
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| Principal transduction |
-
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| Comment |
Reported to act as a co-receptor for HIV [23]. In an infection-induced colitis model, Gpr15 knockout mice were more prone to tissue damage and inflammatory cytokine expression [54].
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GPR17
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| Nomenclature |
GPR17
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| Previous and unofficial names |
Uracil nucleotide/cysteinyl leukotriene receptor,
UDP/CysLT receptor,
P2Y-like receptor,
R12,
GPR17,
G-protein coupled receptor 17,
G protein-coupled receptor 17,
uracil nucleotide/cysteinyl leukotriene receptor,
AI853548
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| Genes |
GPR17 (Hs), Gpr17 (Mm), Gpr17 (Rn) |
| Ensembl ID |
ENSG00000144230 (Hs), ENSMUSG00000052229 (Mm), ENSRNOG00000025745 (Rn)
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| UniProtKB AC |
Q13304 (Hs), Q6NS65 (Mm), Q09QM4 (Rn)
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| Principal transduction |
-
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| Endogenous agonists |
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| Comment |
Reported to be a dual leukotriene and UDP receptor [19]. Another group instead proposed that GPR17 functions as a negative regulator of the CysLT1 receptor response to leukotriene D4 (LTD4). For further discussion, see [20]. Reported to antagonize CysLT1 receptor signalling in vivo and in vitro [76].
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GPR18
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| Nomenclature |
GPR18
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| Previous and unofficial names |
GPR18,
G-protein coupled receptor 18,
NAGly receptor,
GPCRW,
N-arachidonoyol glycine receptor,
Gpr18_predicted,
LOC306191,
LOC679957,
MGC156838,
G protein-coupled receptor 18,
G protein-coupled receptor 18 (predicted),
similar to G protein-coupled receptor 18
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| Genes |
GPR18 (Hs), Gpr18 (Mm), Gpr18 (Rn) |
| Ensembl ID |
ENSG00000125245 (Hs), ENSMUSG00000050350 (Mm), ENSRNOG00000012628 (Rn)
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| UniProtKB AC |
Q14330 (Hs), Q8K1Z6 (Mm), A1A5S3 (Rn)
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| Principal transduction |
Gi/o [56]
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| Endogenous agonists |
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| Comment |
The pairing of N-arachidonoylglycine with GPR18 was not replicated in two studies based on β-arrestin assays [110,128].
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GPR19
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GPR20
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| Nomenclature |
GPR20
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| Previous and unofficial names |
Gpcr5-1,
P2Y4,
GPR20,
G-protein coupled receptor 20,
G protein-coupled receptor 20,
G protein-coupled receptor 5-1,
A430106B11Rik
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| Genes |
GPR20 (Hs), Gpr20 (Mm), Gpr20 (Rn) |
| Ensembl ID |
ENSG00000204882 (Hs), ENSMUSG00000045281 (Mm), ENSRNOG00000007795 (Rn)
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| UniProtKB AC |
Q99678 (Hs), Q8BYC4 (Mm), O35797 (Rn)
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| Principal transduction |
-
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| Comment |
Reported to inhibit adenylyl cyclase constitutively through Gi/o [35]. GPR20 deficient mice exhibit hyperactivity characterised by increased total distance travelled in an open field test [9].
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GPR21
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| Nomenclature |
GPR21
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| Previous and unofficial names |
LOC689917,
G protein-coupled receptor 21,
probable G-protein coupled receptor 21,
similar to G protein-coupled receptor 21,
C230004C13Rik
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| Genes |
GPR21 (Hs), Gpr21 (Mm), Gpr21 (Rn) |
| Ensembl ID |
ENSG00000188394 (Hs), ENSMUSG00000053164 (Mm), ENSRNOG00000042269 (Rn)
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| UniProtKB AC |
Q99679 (Hs), Q8BX79 (Mm)
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| Principal transduction |
Gq/11
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| Comment |
Gpr21 knockout mice were resistant to diet-induced obesity, exhibiting an increase in glucose tolerance and insulin sensitivity and a modest lean phenotype [91].
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GPR22
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| Nomenclature |
GPR22
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| Previous and unofficial names |
Gpr22_predicted,
LOC298944,
G protein-coupled receptor 22,
G protein-coupled receptor 22 (predicted),
probable G-protein coupled receptor 22,
2900068K05Rik,
AW061316
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| Genes |
GPR22 (Hs), Gpr22 (Mm), Gpr22 (Rn) |
| Ensembl ID |
ENSG00000172209 (Hs), ENSMUSG00000044067 (Mm), ENSRNOG00000008423 (Rn)
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| UniProtKB AC |
Q99680 (Hs), Q8BZL4 (Mm), D4A3U0 (Rn)
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| Principal transduction |
Gi/o
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| Comment |
Gene disruption results in increased severity of functional decompensation following aortic banding [1]. Identified as a susceptibility locus for osteoarthritis [27,53,118].
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GPR25
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| Nomenclature |
GPR25
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| Previous and unofficial names |
GPR25,
G-protein coupled receptor 25,
probable G-protein coupled receptor 25,
Gpr25_predicted,
LOC363993,
G protein-coupled receptor 25,
G protein-coupled receptor 25 (predicted),
LOC383563,
Gm1300
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| Genes |
GPR25 (Hs), Gpr25 (Mm), Gpr25 (Rn) |
| Ensembl ID |
ENSG00000170128 (Hs), ENSMUSG00000052759 (Mm), ENSRNOG00000008603 (Rn)
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| UniProtKB AC |
O00155 (Hs), P0C5I1 (Mm)
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| Principal transduction |
-
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GPR26
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| Nomenclature |
GPR26
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| Previous and unofficial names |
GPR26,
G-protein coupled receptor 26,
G protein-coupled receptor 26,
probable G-protein coupled receptor 26,
9630036A11Rik
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| Genes |
GPR26 (Hs), Gpr26 (Mm), Gpr26 (Rn) |
| Ensembl ID |
ENSG00000154478 (Hs), ENSMUSG00000040125 (Mm), ENSRNOG00000047057 (Rn)
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| UniProtKB AC |
Q8NDV2 (Hs), Q8BZA7 (Mm), Q9QXI3 (Rn)
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| Principal transduction |
Gs
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| Comment |
Has been reported to activate adenylyl cyclase constitutively through Gs [46]. Gpr26 knockout mice show increased levels of anxiety and depression-like behaviours [131].
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GPR27
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| Nomenclature |
GPR27
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| Previous and unofficial names |
super conserved receptor expressed in brain 1,
SREB1,
super-conserved receptor expressed in brain 1,
GPR27,
G-protein coupled receptor 27,
probable G-protein coupled receptor 27,
G protein-coupled receptor 27
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| Genes |
GPR27 (Hs), Gpr27 (Mm), Gpr27 (Rn) |
| Ensembl ID |
ENSG00000170837 (Hs), ENSMUSG00000072875 (Mm), ENSRNOG00000010880 (Rn)
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| UniProtKB AC |
Q9NS67 (Hs), O54897 (Mm), Q9JJH3 (Rn)
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| Principal transduction |
Gq/G11
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| Comment |
Knockdown of Gpr27 reduces endogenous mouse insulin promotor activity and glucose stimulated insulin secretion [61].
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GPR31
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| Nomenclature |
GPR31
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| Previous and unofficial names |
bA517H2.2,
GPR31,
G protein-coupled receptor 31,
probable G-protein coupled receptor 31,
HETER1,
12-HETER,
hydroxyeicosatetraenoic (HETE) acid receptor 1,
12-(S)-HETE acid receptor,
Gpr31_predicted,
LOC292310,
G protein-coupled receptor 31 (predicted),
G protein-coupled receptor 31, D17Leh66c region (pseudogene)
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| Genes |
GPR31 (Hs), Gpr31c (Mm), Gpr31 (Rn) |
| Ensembl ID |
ENSG00000120436 (Hs), ENSMUSG00000071311 (Mm), ENSRNOG00000039255 (Rn)
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| UniProtKB AC |
O00270 (Hs), F8VQN3 (Mm)
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| Principal transduction |
-
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| Endogenous agonists |
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GPR32
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| Nomenclature |
GPR32
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| Previous and unofficial names |
GPR32,
G-protein coupled receptor 32,
probable G-protein coupled receptor 32,
RvD1,
RVDR1,
resolvin D1 receptor
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| Genes |
GPR32 (Hs) |
| Ensembl ID |
ENSG00000142511 (Hs)
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| UniProtKB AC |
O75388 (Hs)
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| Principal transduction |
Not yet established
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Rank order of potency
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resolvin D1 > LXA4
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| Endogenous agonists |
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| Labelled ligands |
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| Comment |
resolvin D1 has been demonstrated to activate GPR32 in two publications [17,60]. The pairing was not replicated in a recent study based on β-arrestin recruitment [110]. GPR32 is a pseudogene in mice and rats.
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GPR33
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| Nomenclature |
GPR33
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| Previous and unofficial names |
G protein-coupled receptor 33, pseudogene,
G protein-coupled receptor 33 pseudogene,
G protein-coupled receptor 33,
Gpr33,
Gpr33_predicted,
LOC299007,
G protein-coupled receptor 33 (predicted),
probable G-protein coupled receptor 33
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| Genes |
GPR33 (Hs), Gpr33 (Mm), Gpr33 (Rn) |
| Ensembl ID |
ENSG00000214943 (Hs), ENSMUSG00000035148 (Mm), ENSRNOG00000038990 (Rn)
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| UniProtKB AC |
Q49SQ1 (Hs), O88416 (Mm), Q49SP8 (Rn)
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| Principal transduction |
Gi/Go
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| Comment |
GPR33 is a pseudogene in most individuals, containing a premature stop codon within the coding sequence of the second intracellular loop [104].
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GPR34
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| Nomenclature |
GPR34
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| Previous and unofficial names |
GPR34,
GPR34_predicted,
G protein-coupled receptor 34,
G-protein-coupled receptor GPR34,
G-protein-coupled receptor GPR34 (predicted),
probable G-protein coupled receptor 34
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| Genes |
GPR34 (Hs), Gpr34 (Mm), Gpr34 (Rn) |
| Ensembl ID |
ENSG00000171659 (Hs), ENSMUSG00000040229 (Mm), ENSRNOG00000039759 (Rn)
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| UniProtKB AC |
Q9UPC5 (Hs), Q9R1K6 (Mm), Q6XCE7 (Rn)
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| Principal transduction |
Gi/Go
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| Endogenous agonists |
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| Comment |
Lysophosphatidylserine has been reported to be a ligand of GPR34 in several publications, but the pairing was not replicated in a recent study based on β-arrestin recruitment [110]. Fails to respond to a variety of lipid-derived agents [128]. Gene disruption results in an enhanced immune response [69].
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GPR35
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| Nomenclature |
GPR35
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| Previous and unofficial names |
GPR35,
G-protein coupled receptor 35,
G protein-coupled receptor 35,
Kynurenic acid receptor,
KYNA receptor,
G-protein coupled receptor 3,
Gpr35_predicted,
LOC367315,
G protein-coupled receptor 35 (predicted)
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| Genes |
GPR35 (Hs), Gpr35 (Mm), Gpr35 (Rn) |
| Ensembl ID |
ENSG00000178623 (Hs), ENSMUSG00000026271 (Mm), ENSRNOG00000024030 (Rn)
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| UniProtKB AC |
Q9HC97 (Hs), Q9ES90 (Mm), Q33BM1 (Rn)
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| Principal transduction |
-
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| Endogenous agonists |
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| Comment |
Several studies have shown that kynurenic acid is an agonist of GPR35 but it remains controversial whether the proposed endogenous ligand reaches sufficient tissue concentrations to activate the receptor [62]. 2-oleoyl-LPA has also been proposed as an endogenous ligand [89] but these results were not replicated in in a recent β-arrestin assay [110]. The phosphodiesterase inhibitor zaprinast [115] has become widely used as a surrogate agonist to investigate GPR35 pharmacology and signaliing [115]. GPR35 is also activated by the pharmaceutical adjunct pamoic acid [133].
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GPR37
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| Nomenclature |
GPR37
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| Previous and unofficial names |
ETBR-LP-1,
EDNRBL,
Endothelin B receptor-like protein 1,
PAELR,
EDNRLB,
GPR37,
G protein-coupled receptor 37 (endothelin receptor type B-like),
hET(B)R-LP,
probable G-protein coupled receptor 37,
endothelin receptor type B-like,
Parkin-associated endothelin receptor-like receptor,
MGC105347,
G protein-coupled receptor 37,
G-protein coupled receptor CNS1,
Pael-R,
parkin-associated endothelin B-like receptor,
AI848630
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| Genes |
GPR37 (Hs), Gpr37 (Mm), Gpr37 (Rn) |
| Ensembl ID |
ENSG00000170775 (Hs), ENSMUSG00000039904 (Mm), ENSRNOG00000002524 (Rn)
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| UniProtKB AC |
O15354 (Hs), Q9QY42 (Mm), Q9QYC6 (Rn)
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| Principal transduction |
Gi/Go
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| Selective agonists |
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| Comment |
Reported to associate and regulate the dopamine transporter [81] and to be a substrate for parkin [79]. Gene disruption results in altered striatal signalling [80].
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GPR37L1
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| Nomenclature |
GPR37L1
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| Previous and unofficial names |
G-protein coupled receptor 37-like 1,
D0Kist8,
CAG-18,
ETBR-LP-2,
GPR37L1,
ET(B)R-LP-2,
ETBRLP2,
G protein-coupled receptor 37 like 1,
endothelin B receptor-like protein 2,
G-protein coupled receptor CNS2,
AW047233
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| Genes |
GPR37L1 (Hs), Gpr37l1 (Mm), Gpr37l1 (Rn) |
| Ensembl ID |
ENSG00000170075 (Hs), ENSMUSG00000026424 (Mm), ENSRNOG00000006237 (Rn)
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| UniProtKB AC |
O60883 (Hs), Q99JG2 (Mm), Q9QYC5 (Rn)
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| Principal transduction |
Gi/Go
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GPR39
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| Nomenclature |
GPR39
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| Previous and unofficial names |
MGC149541,
GPR39,
G-protein coupled receptor 39,
Gpr39_predicted,
LOC288995,
G protein-coupled receptor 39,
G protein-coupled receptor 39 (predicted),
4933415E13Rik
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| Genes |
GPR39 (Hs), Gpr39 (Mm), Gpr39 (Rn) |
| Ensembl ID |
ENSG00000183840 (Hs), ENSMUSG00000026343 (Mm), ENSRNOG00000021586 (Rn)
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| UniProtKB AC |
O43194 (Hs), Q5U431 (Mm)
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| Principal transduction |
Gq/G11
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| Endogenous agonists |
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| Comment |
Zn2+ has been reported to be a potent and efficacious agonist of human, mouse and rat GPR39 [127]. obestatin (GHRL, Q9UBU3), a fragment from the ghrelin precursor, was reported initially as an endogenous ligand, but subsequent studies failed to reproduce these findings. Has been reported to be down-regulated in adipose tissue in obesity-related diabetes [12]. Gene disruption results in obesity and altered adipocyte metabolism [95].
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GPR42
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| Nomenclature |
GPR42
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| Previous and unofficial names |
FFAR1L,
GPR41L,
GPR42P,
FFAR3L,
G protein-coupled receptor 42 pseudogene
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| Genes |
GPR42 (Hs) |
| Ensembl ID |
ENSG00000126251 (Hs)
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| UniProtKB AC |
O15529 (Hs)
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| Principal transduction |
-
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GPR45
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| Nomenclature |
GPR45
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| Previous and unofficial names |
PSP24-1,
PSP24-alpha,
PSP24A,
PSP24,
GPR45,
G-protein coupled receptor 45,
high-affinity lysophosphatidic acid receptor,
probable G-protein coupled receptor 45,
PSP24(ALPHA),
Gpr45_predicted,
LOC301372,
G protein-coupled receptor 45,
G protein-coupled receptor 45 (predicted),
PSP24alpha,
9230112G11Rik,
AW046772
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| Genes |
GPR45 (Hs), Gpr45 (Mm), Gpr45 (Rn) |
| Ensembl ID |
ENSG00000135973 (Hs), ENSMUSG00000041907 (Mm), ENSRNOG00000016446 (Rn)
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| UniProtKB AC |
Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
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| Principal transduction |
-
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GPR50
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| Nomenclature |
GPR50
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| Previous and unofficial names |
MGC125342,
MTNRL,
H9,
GPR50,
G-protein coupled receptor 50,
Mel1c,
melatonin-related receptor
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| Genes |
GPR50 (Hs), Gpr50 (Mm), Gpr50 (Rn) |
| Ensembl ID |
ENSG00000102195 (Hs), ENSMUSG00000056380 (Mm), ENSRNOG00000011335 (Rn)
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| UniProtKB AC |
Q13585 (Hs), O88495 (Mm), Q62953 (Rn)
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| Principal transduction |
-
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| Comment |
GPR50 is structurally related to MT1 and MT2 melatonin receptors, with which it heterodimerises constitutively and specifically [67]. GPR50 knockout mice display abnormal thermoregulation and are much more likely than wild-type mice to enter fasting-induced torpor [4].
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GPR52
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| Nomenclature |
GPR52
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| Previous and unofficial names |
MGC111751,
EG620246,
GPR52,
G-protein coupled receptor 52,
probable G-protein coupled receptor 52,
LOC680192,
G protein-coupled receptor 52,
similar to Probable G-protein coupled receptor 52
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| Genes |
GPR52 (Hs), Gpr52 (Mm), Gpr52 (Rn) |
| Ensembl ID |
ENSG00000203737 (Hs)
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| UniProtKB AC |
Q9Y2T5 (Hs), P0C5J4 (Mm)
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| Principal transduction |
-
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GPR55
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| Nomenclature |
GPR55
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| Previous and unofficial names |
GPR55,
G protein-coupled receptor 55,
Gpr55_predicted,
G protein-coupled receptor 55 (predicted),
G-protein coupled receptor 55,
LOC227326,
Gm218
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| Genes |
GPR55 (Hs), Gpr55 (Mm), Gpr55 (Rn) |
| Ensembl ID |
ENSG00000135898 (Hs), ENSMUSG00000049608 (Mm), ENSRNOG00000017521 (Rn)
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| UniProtKB AC |
Q9Y2T6 (Hs), Q3UJF0 (Mm), Q9WU09 (Rn)
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| Principal transduction |
G12/13[103]
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| Endogenous agonists |
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| Selective agonists |
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GPR61
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| Nomenclature |
GPR61
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| Previous and unofficial names |
GPCR3,
BALGR,
GPR61,
G protein-coupled receptor 61,
Biogenic amine receptor-like G-protein coupled receptor,
probable G-protein coupled receptor 61,
biogenic amine receptor-like GPCR,
Gpr61_predicted,
LOC310780,
G protein-coupled receptor 61 (predicted)
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| Genes |
GPR61 (Hs), Gpr61 (Mm), Gpr61 (Rn) |
| Ensembl ID |
ENSG00000156097 (Hs), ENSMUSG00000046793 (Mm), ENSRNOG00000019738 (Rn)
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| UniProtKB AC |
Q9BZJ8 (Hs), Q8C010 (Mm)
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| Principal transduction |
Gs
|
| Comment |
GPR61 deficient mice exhibit obesity associated with hyperphagia [84]. Although no endogenous ligands have been identified, 5-(nonyloxy)tryptamine has been reported to be a low affinity inverse agonist [114].
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|
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GPR62
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| Nomenclature |
GPR62
|
| Previous and unofficial names |
KPG_005,
MGC26943,
GPCR8,
LOC501049,
RGD1560166_predicted,
similar to Probable G-protein coupled receptor 62 (hGPCR8),
similar to Probable G-protein coupled receptor 62 (hGPCR8) (predicted),
4933402E03Rik
|
| Genes |
GPR62 (Hs), Gpr62 (Mm), Gpr62 (Rn) |
| Ensembl ID |
ENSG00000180929 (Hs), ENSMUSG00000091735 (Mm), ENSRNOG00000022567 (Rn)
|
| UniProtKB AC |
Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn)
|
| Principal transduction |
-
|
|
|
GPR63
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| Nomenclature |
GPR63
|
| Previous and unofficial names |
PSP24(beta),
PSP24-2,
PSP24B,
Gpr63_predicted,
LOC297952,
G protein-coupled receptor 63,
G protein-coupled receptor 63 (predicted),
probable G-protein coupled receptor 63,
PSP24beta
|
| Genes |
GPR63 (Hs), Gpr63 (Mm), Gpr63 (Rn) |
| Ensembl ID |
ENSG00000112218 (Hs), ENSMUSG00000040372 (Mm), ENSRNOG00000007675 (Rn)
|
| UniProtKB AC |
Q9BZJ6 (Hs), Q9EQQ3 (Mm)
|
| Principal transduction |
-
|
| Comment |
sphingosine 1-phosphate and dioleoylphosphatidic acid have been reported to be low affinity agonists for GPR63 [86] but this finding was not replicated in a β-arrestin-based assay [128].
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|
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GPR65
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| Nomenclature |
GPR65
|
| Previous and unofficial names |
Psychosine receptor,
T cell death-associated protein 8,
Dig1,
Gpcr25,
TDAG8,
GPR65,
G-protein coupled receptor 65,
hTDAG8,
Gpr65_predicted,
LOC299242,
G-protein coupled receptor 65 (predicted),
T cell death associated protein 8,
rCG_20955
|
| Genes |
GPR65 (Hs), Gpr65 (Mm), Gpr65 (Rn) |
| Ensembl ID |
ENSG00000140030 (Hs), ENSMUSG00000021886 (Mm), ENSRNOG00000003806 (Rn)
|
| UniProtKB AC |
Q8IYL9 (Hs), Q61038 (Mm)
|
| Principal transduction |
Gs
|
|
Endogenous ligand
|
Protons
|
| Comment |
GPR4, GPR65, GPR68 and GPR132 are now thought to function as proton-sensing receptors detecting acidic pH [20,105]. Reported to activate adenylyl cyclase; gene disruption leads to reduced eosinophlia in models of allergic airway disease [59].
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|
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GPR68
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| Nomenclature |
GPR68
|
| Previous and unofficial names |
Ovarian cancer G-protein coupled receptor 1,
OGR-1,
GPR12A,
MGC111379,
sphingosylphosphorylcholine receptor,
OGR1,
Gpr68_predicted,
LOC314386,
G protein-coupled receptor 68,
G protein-coupled receptor 68 (predicted),
BB131428
|
| Genes |
GPR68 (Hs), Gpr68 (Mm), Gpr68 (Rn) |
| Ensembl ID |
ENSG00000119714 (Hs), ENSMUSG00000047415 (Mm), ENSRNOG00000027863 (Rn)
|
| UniProtKB AC |
Q15743 (Hs), Q8BFQ3 (Mm)
|
| Principal transduction |
-
|
|
Endogenous ligand
|
Protons
|
| Comment |
Gpr68 was previously identified as a receptor for sphingosylphosphorylcholine (SPC) [124], but the original publication has been retracted [125]. GPR4, GPR65, GPR68 and GPR132 are now thought to function as protein-sensing receptors detecting acidic pH [20,105]. A family of 3,5-disubstituted isoxazoles were identified as agonists of GPR68 [102].
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|
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GPR75
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More detailed page
| Nomenclature |
GPR75
|
| Previous and unofficial names |
GPR-chr2,
WI-31133,
WI31133,
GPR75,
G-protein coupled receptor 75,
GPRchr2,
probable G-protein coupled receptor 75,
LOC498434,
RGD1566385,
RGD1566385_predicted,
G protein-coupled receptor 75,
G protein-coupled receptor GPR75,
similar to G protein-coupled receptor GPR75,
similar to G protein-coupled receptor GPR75 (predicted)
|
| Genes |
GPR75 (Hs), Gpr75 (Mm), Gpr75 (Rn) |
| Ensembl ID |
ENSG00000119737 (Hs), ENSMUSG00000043999 (Mm), ENSRNOG00000022176 (Rn)
|
| UniProtKB AC |
O95800 (Hs), Q6X632 (Mm), D3Z826 (Rn)
|
| Principal transduction |
Gq/G11
|
| Comment |
CCL5 (CCL5, P13501) was reported to be an agonist of GPR75 [43], but the pairing could not be repeated in a recent β-arrestin assay [110].
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|
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GPR78
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| Nomenclature |
GPR78
|
| Previous and unofficial names |
GPR78,
G-protein coupled receptor 78
|
| Genes |
GPR78 (Hs) |
| Ensembl ID |
ENSG00000155269 (Hs)
|
| UniProtKB AC |
Q96P69 (Hs)
|
| Principal transduction |
Gs
|
| Comment |
GPR78 has been reported to be constitutively active, coupled to elevated cAMP production [46].
|
|
|
GPR79
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| Nomenclature |
GPR79
|
| Previous and unofficial names |
G protein-coupled receptor 79 pseudogene,
GPR79,
GPR79P
|
| Genes |
GPR79 (Hs) |
| Ensembl ID |
ENSG00000232374 (Hs)
|
| UniProtKB AC |
-
|
| Principal transduction |
-
|
|
|
GPR82
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More detailed page
| Nomenclature |
GPR82
|
| Previous and unofficial names |
-
|
| Genes |
GPR82 (Hs), Gpr82 (Mm) |
| Ensembl ID |
ENSG00000171657 (Hs), ENSMUSG00000047678 (Mm)
|
| UniProtKB AC |
Q96P67 (Hs), Q8BZR0 (Mm)
|
| Principal transduction |
-
|
| Comment |
Mice with Gpr82 knockout have a lower body weight and body fat content associated with reduced food intake, decreased serum triglyceride levels, higher insulin sensitivity and glucose tolerance [26].
|
|
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GPR83
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More detailed page
| Nomenclature |
GPR83
|
| Previous and unofficial names |
GPR72,
KIAA1540,
glucocorticoid-induced receptor,
GIR,
RP105,
RP39,
RP82,
GPR83,
G-protein coupled receptor 83,
G protein-coupled receptor 83,
G-protein coupled receptor 72,
glucocorticoid induced receptor,
probable G-protein coupled receptor,
JP05 [10],
G protein-coupled receptor 72,
probable G-protein coupled receptor 83,
AW045253
|
| Genes |
GPR83 (Hs), Gpr83 (Mm), Gpr83 (Rn) |
| Ensembl ID |
ENSG00000123901 (Hs), ENSMUSG00000031932 (Mm), ENSRNOG00000030318 (Rn)
|
| UniProtKB AC |
Q9NYM4 (Hs), P30731 (Mm)
|
| Principal transduction |
-
|
| Comment |
One isoform has been implicated in the induction of CD4(+)CD25(+) regulatory T cells (Tregs) during inflammatory immune responses [34].
|
|
|
GPR84
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| Nomenclature |
GPR84
|
| Previous and unofficial names |
EX33,
GPR84,
G-protein coupled receptor 84,
G protein-coupled receptor 84,
Inflammation-related G-protein coupled receptor EX33,
GPCR4,
LOC688730,
similar to G protein-coupled receptor 84
|
| Genes |
GPR84 (Hs), Gpr84 (Mm), Gpr84 (Rn) |
| Ensembl ID |
ENSG00000139572 (Hs), ENSMUSG00000063234 (Mm), ENSRNOG00000036834 (Rn)
|
| UniProtKB AC |
Q9NQS5 (Hs), Q8CIM5 (Mm)
|
| Principal transduction |
Gi/Go
|
| Selective agonists |
|
| Comment |
Medium chain free fatty acids with carbon chain lengths of 9-14 activate GPR84 [112,121]. A surrogate ligand for GPR84, 6-n-octylaminouracil has also been proposed [112].
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|
|
GPR85
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| Nomenclature |
GPR85
|
| Previous and unofficial names |
Super Conserved Receptor Expressed in Brain 2,
Srep2,
MGC105281,
SREB2,
GPR85,
G protein-coupled receptor 85,
Super conserved receptor expressed in brain 2,
seven transmembrane helix receptor,
probable G-protein coupled receptor 85,
SREB,
PKrCx1,
2900026B03Rik,
rgpr85
|
| Genes |
GPR85 (Hs), Gpr85 (Mm), Gpr85 (Rn) |
| Ensembl ID |
ENSG00000164604 (Hs), ENSMUSG00000048216 (Mm), ENSRNOG00000024636 (Rn)
|
| UniProtKB AC |
P60893 (Hs), P60894 (Mm), P60895 (Rn)
|
| Principal transduction |
-
|
| Comment |
Proposed to regulate of hippocampal adult neurogenesis and neurogenesis-dependent learning and memory [16].
|
|
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GPR87
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| Nomenclature |
GPR87
|
| Previous and unofficial names |
FKSG78,
KPG_002,
MGC131898,
GPR95,
Gpr87_predicted,
LOC310443,
G protein-coupled receptor 87,
G protein-coupled receptor 87 (predicted),
G-protein coupled receptor 87
|
| Genes |
GPR87 (Hs), Gpr87 (Mm), Gpr87 (Rn) |
| Ensembl ID |
ENSG00000138271 (Hs), ENSMUSG00000051431 (Mm), ENSRNOG00000013894 (Rn)
|
| UniProtKB AC |
Q9BY21 (Hs), Q99MT7 (Mm)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
|
|
GPR88
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| Nomenclature |
GPR88
|
| Previous and unofficial names |
Strg,
STRG,
GPR88,
G-protein coupled receptor 88,
probable G-protein coupled receptor 88,
G protein coupled receptor 88,
G protein-coupled receptor 88,
striatum-specific G-protein coupled receptor,
AW061286
|
| Genes |
GPR88 (Hs), Gpr88 (Mm), Gpr88 (Rn) |
| Ensembl ID |
ENSG00000181656 (Hs), ENSMUSG00000068696 (Mm), ENSRNOG00000026953 (Rn)
|
| UniProtKB AC |
Q9GZN0 (Hs), Q9EPB7 (Mm), Q9ESP4 (Rn)
|
| Principal transduction |
-
|
| Comment |
Gene disruption results in altered striatal signalling [73].
|
|
|
GPR101
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| Nomenclature |
GPR101
|
| Previous and unofficial names |
GPCR6,
RGD1564196,
GPR101,
G-protein coupled receptor 101,
probable G-protein coupled receptor 101,
Gpr101_predicted,
LOC317608,
RGD1564196_predicted,
G protein-coupled receptor 101,
G protein-coupled receptor 101 (predicted),
similar to G protein-coupled receptor 101,
similar to G protein-coupled receptor 101 (predicted),
LOC245424,
Gm365
|
| Genes |
GPR101 (Hs), Gpr101 (Mm), Gpr101 (Rn) |
| Ensembl ID |
ENSG00000165370 (Hs), ENSMUSG00000036357 (Mm), ENSRNOG00000027658 (Rn)
|
| UniProtKB AC |
Q96P66 (Hs), Q80T62 (Mm), D4ABK4 (Rn)
|
| Principal transduction |
Gs
|
|
|
GPR119
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| Nomenclature |
GPR119
|
| Previous and unofficial names |
hGPCR2,
GPCR2,
SNORF25,
GPR119,
G-protein coupled receptor 119,
G-protein coupled receptor 2,
glucose-dependent insulinotropic receptor,
G protein-coupled receptor 119
|
| Genes |
GPR119 (Hs), Gpr119 (Mm), Gpr119 (Rn) |
| Ensembl ID |
ENSG00000147262 (Hs), ENSMUSG00000051209 (Mm), ENSRNOG00000024517 (Rn)
|
| UniProtKB AC |
Q8TDV5 (Hs), Q7TQP3 (Mm), Q7TQN8 (Rn)
|
| Principal transduction |
Gs [87,92]
|
|
Rank order of potency
|
N-oleoylethanolamide, N-palmitoylethanolamine > SEA (anandamide is ineffective)
[92]
|
| Endogenous agonists |
|
| Selective agonists |
|
|
|
GPR132
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| Nomenclature |
GPR132
|
| Previous and unofficial names |
MGC99642,
G2A,
GPR132,
G-protein coupled receptor 132,
G2 accumulation protein,
G protein-coupled receptor G2A,
probable G-protein coupled receptor 132,
G2 accumulation,
Gpr132_predicted,
LOC314480,
G protein-coupled receptor 132,
G protein-coupled receptor 132 (predicted)
|
| Genes |
GPR132 (Hs), Gpr132 (Mm), Gpr132 (Rn) |
| Ensembl ID |
ENSG00000183484 (Hs), ENSMUSG00000021298 (Mm), ENSRNOG00000013914 (Rn)
|
| UniProtKB AC |
Q9UNW8 (Hs), Q9Z282 (Mm), D3ZIH1 (Rn)
|
| Principal transduction |
Gs
|
|
Endogenous ligand
|
Protons
|
| Comment |
GPR4, GPR65, GPR68 and GPR132 are now thought to function as protein-sensing receptors detecting acidic pH [20,105]. Reported to respond to lysophosphatidylcholine [47], but later retracted [123].
|
|
|
GPR135
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| Nomenclature |
GPR135
|
| Previous and unofficial names |
PAFR,
HUMNPIIY20,
GPR135,
G-protein coupled receptor 135,
probable G-protein coupled receptor 135,
G protein-coupled receptor 135
|
| Genes |
GPR135 (Hs), Gpr135 (Mm), Gpr135 (Rn) |
| Ensembl ID |
ENSG00000181619 (Hs), ENSMUSG00000043398 (Mm), ENSRNOG00000004499 (Rn)
|
| UniProtKB AC |
Q8IZ08 (Hs), Q7TQP2 (Mm), Q7TQN7 (Rn)
|
| Principal transduction |
-
|
|
|
GPR139
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| Nomenclature |
GPR139
|
| Previous and unofficial names |
GPRg1,
PGR3,
GPR139,
G-protein coupled receptor 139,
G(q)-coupled orphan receptor GPRg1,
G-protein-coupled receptor PGR3,
probable G-protein coupled receptor 139,
GPRG1,
Gpr139_predicted,
LOC293545,
G protein-coupled receptor 139,
G protein-coupled receptor 139 (predicted),
LOC209776,
Gm495
|
| Genes |
GPR139 (Hs), Gpr139 (Mm), Gpr139 (Rn) |
| Ensembl ID |
ENSG00000180269 (Hs), ENSMUSG00000066197 (Mm), ENSRNOG00000023863 (Rn)
|
| UniProtKB AC |
Q6DWJ6 (Hs), Q80UC8 (Mm), P0C0W8 (Rn)
|
| Principal transduction |
Gq/G11
|
|
|
GPR141
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| Nomenclature |
GPR141
|
| Previous and unofficial names |
PGR13,
GPR141,
G-protein coupled receptor 141,
G-protein coupled receptor PGR13,
probable G-protein coupled receptor 141,
axor115,
G protein-coupled receptor 141
|
| Genes |
GPR141 (Hs), Gpr141 (Mm), Gpr141 (Rn) |
| Ensembl ID |
ENSG00000187037 (Hs), ENSMUSG00000053101 (Mm), ENSRNOG00000042801 (Rn)
|
| UniProtKB AC |
Q7Z602 (Hs), Q7TQP0 (Mm), Q7TQN5 (Rn)
|
| Principal transduction |
-
|
|
|
GPR142
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| Nomenclature |
GPR142
|
| Previous and unofficial names |
PGR2,
KIF19,
GPR142,
G-protein coupled receptor 142,
G-protein coupled receptor PGR2,
probable G-protein coupled receptor 142,
AXOR103,
LOC501735,
RGD1559926,
RGD1559926_predicted,
G protein-coupled receptor 142,
similar to G protein-coupled receptor 142,
similar to G protein-coupled receptor 142 (predicted)
|
| Genes |
GPR142 (Hs), Gpr142 (Mm), Gpr142 (Rn) |
| Ensembl ID |
ENSG00000196169 (Hs), ENSMUSG00000034677 (Mm), ENSRNOG00000024446 (Rn)
|
| UniProtKB AC |
Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
|
| Principal transduction |
-
|
|
|
GPR146
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| Nomenclature |
GPR146
|
| Previous and unofficial names |
PGR8,
GPR146,
G-protein coupled receptor 146,
G-protein coupled receptor PGR8,
AXOR120,
LOC498153,
RGD1560731,
RGD1560731_predicted,
G protein-coupled receptor 146,
probable G-protein coupled receptor 146,
similar to G protein-coupled receptor 146,
similar to G protein-coupled receptor 146 (predicted),
BC003323
|
| Genes |
GPR146 (Hs), Gpr146 (Mm), Gpr146 (Rn) |
| Ensembl ID |
ENSG00000164849 (Hs), ENSMUSG00000044197 (Mm), ENSRNOG00000001288 (Rn)
|
| UniProtKB AC |
Q96CH1 (Hs), Q99LE2 (Mm)
|
| Principal transduction |
-
|
| Comment |
Yosten et al. demonstrated inhibition of proinsulin C-peptide (INS, P01308)-induced stimulation of cFos expression folllowing knockdown of GPR146 in KATOIII cells, suggesting proinsulin C-peptide as an endogenous ligand of the receptor [130].
|
|
|
GPR148
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More detailed page
| Nomenclature |
GPR148
|
| Previous and unofficial names |
BTR,
PGR6,
brain and testis restricted GPCR,
GPR148,
G-protein coupled receptor 148,
G-protein coupled receptor PGR6,
probable G-protein coupled receptor 148
|
| Genes |
GPR148 (Hs) |
| Ensembl ID |
ENSG00000173302 (Hs)
|
| UniProtKB AC |
Q8TDV2 (Hs)
|
| Principal transduction |
-
|
|
|
GPR149
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| Nomenclature |
GPR149
|
| Previous and unofficial names |
PGR10,
IEDA,
GPR149,
G-protein coupled receptor 149,
G-protein coupled receptor PGR10,
probable G-protein coupled receptor 149,
R35,
G protein-coupled receptor 149,
induced early in differentiating astrocytes gene protein,
orphan seven transmembrane receptor,
9630018L10Rik
|
| Genes |
GPR149 (Hs), Gpr149 (Mm), Gpr149 (Rn) |
| Ensembl ID |
ENSG00000174948 (Hs), ENSMUSG00000043441 (Mm), ENSRNOG00000014793 (Rn)
|
| UniProtKB AC |
Q86SP6 (Hs), Q3UVY1 (Mm), Q924Y8 (Rn)
|
| Principal transduction |
-
|
| Comment |
Gpr149 knockout mice displayed increased fertility and enhanced ovulation, with increased levels of FSH receptor and cyclin D2 mRNA levels [24].
|
|
|
GPR150
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| Nomenclature |
GPR150
|
| Previous and unofficial names |
PGR11,
GPR150,
G-protein coupled receptor 150,
seven transmembrane helix receptor,
probable G-protein coupled receptor 150,
AXOR70,
RGD1564729,
LOC499486,
RGD1564729_predicted,
G protein-coupled receptor 150,
similar to G protein-coupled receptor 150,
similar to G protein-coupled receptor 150 (predicted),
C030001A19Rik
|
| Genes |
GPR150 (Hs), Gpr150 (Mm), Gpr150 (Rn) |
| Ensembl ID |
ENSG00000178015 (Hs), ENSMUSG00000045509 (Mm), ENSRNOG00000026944 (Rn)
|
| UniProtKB AC |
Q8NGU9 (Hs), Q8BL07 (Mm)
|
| Principal transduction |
-
|
|
|
GPR151
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| Nomenclature |
GPR151
|
| Previous and unofficial names |
GALRL,
galanin receptor 4,
PGR7,
GALR4,
GPCR-2037,
GPR151,
G-protein coupled receptor 151,
G protein-coupled receptor 151,
G-protein coupled receptor PGR7,
putative G-protein coupled receptor,
probable G-protein coupled receptor 151,
galanin receptor-like GPCR,
AXOR40,
nGPCR-2037,
putative G protein-coupled receptor nGPCR-2037,
C130082O03Rik
|
| Genes |
GPR151 (Hs), Gpr151 (Mm), Gpr151 (Rn) |
| Ensembl ID |
ENSG00000173250 (Hs), ENSMUSG00000042816 (Mm), ENSRNOG00000027103 (Rn)
|
| UniProtKB AC |
Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
|
| Principal transduction |
-
|
| Comment |
GPR151 responded to galanin with an EC50 value of 2 µM, suggesting that the endogenous ligand shares structural features with galanin (GAL, P22466) [40].
|
|
|
GPR152
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| Nomenclature |
GPR152
|
| Previous and unofficial names |
PGR1,
MGC148162,
PGR5,
GPR152,
G-protein coupled receptor 152,
G protein-coupled receptor 152,
probable G-protein coupled receptor 152,
G-protein coupled receptor PGR5,
LOC688884,
similar to putative G-protein coupled receptor,
LOC269053,
A930009H15Rik,
Gm673
|
| Genes |
GPR152 (Hs), Gpr152 (Mm), Gpr152 (Rn) |
| Ensembl ID |
ENSG00000175514 (Hs), ENSMUSG00000044724 (Mm), ENSRNOG00000021912 (Rn)
|
| UniProtKB AC |
Q8TDT2 (Hs), Q8BXS7 (Mm)
|
| Principal transduction |
-
|
|
|
GPR153
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| Nomenclature |
GPR153
|
| Previous and unofficial names |
DKFZp762B2210,
PGR1,
G protein-coupled receptor 153,
probable G-protein coupled receptor 153,
1110065N12Rik,
AI449320
|
| Genes |
GPR153 (Hs), Gpr153 (Mm), Gpr153 (Rn) |
| Ensembl ID |
ENSG00000158292 (Hs), ENSMUSG00000042804 (Mm), ENSRNOG00000010718 (Rn)
|
| UniProtKB AC |
Q6NV75 (Hs), Q8K0Z9 (Mm), Q3KR68 (Rn)
|
| Principal transduction |
-
|
|
|
GPR160
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| Nomenclature |
GPR160
|
| Previous and unofficial names |
GPCR150,
GPCR1,
G protein-coupled receptor 160,
probable G-protein coupled receptor 160,
1700025D19Rik
|
| Genes |
GPR160 (Hs), Gpr160 (Mm), Gpr160 (Rn) |
| Ensembl ID |
ENSG00000173890 (Hs), ENSMUSG00000037661 (Mm), ENSRNOG00000009487 (Rn)
|
| UniProtKB AC |
Q9UJ42 (Hs), Q3U3F9 (Mm), Q66H29 (Rn)
|
| Principal transduction |
-
|
|
|
GPR161
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| Nomenclature |
GPR161
|
| Previous and unofficial names |
FLJ33952,
RE2,
GPR161,
G-protein coupled receptor 161,
G-protein coupled receptor RE2,
LOC289180,
RGD1563245,
RGD1563245_predicted,
G protein-coupled receptor 161,
similar to G protein-coupled receptor 161,
similar to G protein-coupled receptor 161 (predicted),
LOC240888,
vl,
Gm208Gpr
|
| Genes |
GPR161 (Hs), Gpr161 (Mm), Gpr161 (Rn) |
| Ensembl ID |
ENSG00000143147 (Hs), ENSMUSG00000040836 (Mm), ENSRNOG00000003073 (Rn)
|
| UniProtKB AC |
Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn)
|
| Principal transduction |
-
|
| Comment |
A C-terminal truncation (deletion) mutation in Gpr61 causes congenital cataracts and neural tube defects in the vacuolated lens (vl) mouse mutant [82]. The mutated receptor is associated with cataract, spina bifida and white belly spot phenotypes in mice [58]. Gene disruption is associated with a failure of asymmetric embryonic development in zebrafish [66].
|
|
|
GPR162
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| Nomenclature |
GPR162
|
| Previous and unofficial names |
A-2,
GRCA,
GPR162,
G-protein coupled receptor 162,
Gene-rich cluster gene A protein,
gene rich cluster, A,
probable G-protein coupled receptor 162,
Gpr162_predicted,
Grca_predicted,
LOC362436,
G protein-coupled receptor 162,
G protein-coupled receptor 162 (predicted),
gene rich cluster, A gene (predicted),
BC031437
|
| Genes |
GPR162 (Hs), Gpr162 (Mm), Gpr162 (Rn) |
| Ensembl ID |
ENSG00000250510 (Hs), ENSMUSG00000038390 (Mm), ENSRNOG00000016143 (Rn)
|
| UniProtKB AC |
Q16538 (Hs), Q3UN16 (Mm)
|
| Principal transduction |
-
|
|
|
GPR171
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| Nomenclature |
GPR171
|
| Previous and unofficial names |
F730001G15Rik,
H963,
GPR171,
G-protein coupled receptor 171,
G protein-coupled receptor 171,
G-protein coupled receptor H963,
platelet activating receptor homolog,
probable G-protein coupled receptor 171,
LOC688737,
similar to G protein-coupled receptor 171
|
| Genes |
GPR171 (Hs), Gpr171 (Mm), Gpr171 (Rn) |
| Ensembl ID |
ENSG00000174946 (Hs), ENSMUSG00000050075 (Mm), ENSRNOG00000025297 (Rn)
|
| UniProtKB AC |
O14626 (Hs), Q8CIF3 (Mm)
|
| Principal transduction |
-
|
| Comment |
GPR171 has been shown to be activated by endogenous peptide BigLEN. This receptor-peptide interaction is believed to be involved in regulating feeding and metabolism responses [31].
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|
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GPR173
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| Nomenclature |
GPR173
|
| Previous and unofficial names |
SREB3,
Super conserved receptor expressed in brain 3,
GPR173,
G-protein coupled receptor 173,
probable G-protein coupled receptor 173,
G protein coupled receptor 173,
3230401K02Rik
|
| Genes |
GPR173 (Hs), Gpr173 (Mm), Gpr173 (Rn) |
| Ensembl ID |
ENSG00000184194 (Hs), ENSMUSG00000056679 (Mm), ENSRNOG00000003272 (Rn)
|
| UniProtKB AC |
Q9NS66 (Hs), Q6PI62 (Mm), Q9JJH2 (Rn)
|
| Principal transduction |
-
|
|
|
GPR174
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| Nomenclature |
GPR174
|
| Previous and unofficial names |
RGD1564689,
FKSG79,
Gpr174_predicted,
LOC302373,
RGD1564689_predicted,
G protein-coupled receptor 174,
G protein-coupled receptor 174 (predicted),
probable G-protein coupled receptor 174,
similar to putative purinergic receptor FKSG79,
similar to putative purinergic receptor FKSG79 (predicted),
Gm376,
LOC213439
|
| Genes |
GPR174 (Hs), Gpr174 (Mm), Gpr174 (Rn) |
| Ensembl ID |
ENSG00000147138 (Hs), ENSMUSG00000073008 (Mm), ENSRNOG00000032970 (Rn)
|
| UniProtKB AC |
Q9BXC1 (Hs), Q3U507 (Mm)
|
| Principal transduction |
Gs
|
| Endogenous agonists |
|
|
|
GPR176
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More detailed page
| Nomenclature |
GPR176
|
| Previous and unofficial names |
AGR9,
Gm1012,
HB954,
GPR176,
G-protein coupled receptor 176,
HB-954,
probable G-protein coupled receptor 176,
Gpr,
RBU-15,
G-protein coupled receptor AGR9,
gene model 1012, (NCBI),
putative G protein coupled receptor,
LOC381413
|
| Genes |
GPR176 (Hs), Gpr176 (Mm), Gpr176 (Rn) |
| Ensembl ID |
ENSG00000166073 (Hs), ENSMUSG00000040133 (Mm), ENSRNOG00000005971 (Rn)
|
| UniProtKB AC |
Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn)
|
| Principal transduction |
-
|
|
|
GPR182
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More detailed page
| Nomenclature |
GPR182
|
| Previous and unofficial names |
Gpcr22,
MB10,
hrhAMR,
AM-R,
G10-D,
Gpcr17,
NOW,
ADMR,
G-protein coupled receptor 182,
GPR182,
G10D,
AMR,
gamrh,
adrenomedullin receptor,
L1-R [97],
G protein-coupled receptor 182
|
| Genes |
GPR182 (Hs), Gpr182 (Mm), Gpr182 (Rn) |
| Ensembl ID |
ENSG00000166856 (Hs), ENSMUSG00000058396 (Mm), ENSRNOG00000004311 (Rn)
|
| UniProtKB AC |
O15218 (Hs), P43142 (Mm), P31392 (Rn)
|
| Principal transduction |
-
|
| Comment |
Rat GPR182 was first proposed as adrenomedullin receptor [49]. However, it was later reported that rat and human GPR182 did not respond to adrenomedullin [52] and GPR182 is not currently considered to be a genuine adrenomedullin receptor [36].
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|
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GPR183
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| Nomenclature |
GPR183
|
| Previous and unofficial names |
EBV-induced G-protein coupled receptor 2,
EBI2,
Epstein-Barr virus-induced gene 2,
lymphocyte-specific G protein-coupled receptor,
EBV-induced G protein-coupled receptor 2,
GPR183,
Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor),
LOC679975,
G protein-coupled receptor 183,
G-protein coupled receptor 183,
similar to EBV-induced G-protein coupled receptor 2 (EBI2)
|
| Genes |
GPR183 (Hs), Gpr183 (Mm), Gpr183 (Rn) |
| Ensembl ID |
ENSG00000169508 (Hs), ENSMUSG00000051212 (Mm), ENSRNOG00000025094 (Rn)
|
| UniProtKB AC |
P32249 (Hs), Q3U6B2 (Mm), D4A7K7 (Rn)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
| Comment |
Two independent publications have shown that 7α,25-dihydroxycholesterol is an agonist of GPR183 and have demonstrated by mass spectrometry that this oxysterol is present endogenously in tissues [33,70]. Gpr183-deficient mice show reduction in the early antibody response to a T-dependent antigen. GPR183-deficient B cells fail to migrate to the outer follicle and instead stay in the follicle centre [51,94].
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|
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LGR4
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| Nomenclature |
LGR4
|
| Previous and unofficial names |
GPR48,
LGR4,
leucine-rich repeat-containing G protein-coupled receptor 4,
G-protein coupled receptor 48,
G protein-coupled receptor 48,
leucine-rich repeat-containing G-protein coupled receptor 4,
A330106J01Rik,
A930009A08Rik
|
| Genes |
LGR4 (Hs), Lgr4 (Mm), Lgr4 (Rn) |
| Ensembl ID |
ENSG00000205213 (Hs), ENSMUSG00000050199 (Mm), ENSRNOG00000005715 (Rn)
|
| UniProtKB AC |
Q9BXB1 (Hs), A2ARI4 (Mm), Q9Z2H4 (Rn)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
| Comment |
LGR4 does not couple to heterotrimeric G proteins or to β-arrestin when stimulated by the R-spondins, indicating a unique mechanism of action. R-spondins bind to LGR4, which specifically associates with Frizzled and LRPs—proteins that are activated by the extracellular Wnt molecules and then trigger canonical Wnt signalling to increase gene expression [11,21,100]. Gene disruption leads to multiple developmental disorders [45,75,109,122].
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|
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LGR5
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| Nomenclature |
LGR5
|
| Previous and unofficial names |
GPR49,
LGR5,
GPR67,
FEX,
HG38,
MGC117008,
Leucine-rich repeat-containing G protein-coupled receptor 5,
G-protein coupled receptor 49,
G-protein coupled receptor 67,
G-protein coupled receptor HG38,
orphan G protein-coupled receptor HG38,
leucine-rich repeat-containing G-protein coupled receptor 5,
GRP49,
leucine-rich repeat-containing G protein-coupled receptor 5,
G protein-coupled receptor 49,
Gpr49_predicted,
LOC299802,
G protein-coupled receptor 49 (predicted),
leucine rich repeat containing G protein coupled receptor 5
|
| Genes |
LGR5 (Hs), Lgr5 (Mm), Lgr5 (Rn) |
| Ensembl ID |
ENSG00000139292 (Hs), ENSMUSG00000020140 (Mm), ENSRNOG00000004221 (Rn)
|
| UniProtKB AC |
O75473 (Hs), Q9Z1P4 (Mm)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
| Comment |
The four R-spondins can bind to LGR4, LGR5, and LGR6, which specifically associate with Frizzled and LRPs—proteins that are activated by extracellular Wnt molecules- and then trigger canonical Wnt signalling to increase gene expression [11,21].
|
|
|
LGR6
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| Nomenclature |
LGR6
|
| Previous and unofficial names |
FLJ14471,
VTS20631,
LGR6,
leucine-rich repeat-containing G protein-coupled receptor 6,
gonadotropin receptor,
leucine-rich repeat-containing G-protein coupled receptor 6,
LOC498233,
RGD1560339,
RGD1560339_predicted,
similar to VTS20631,
similar to VTS20631 (predicted),
A530037C04Rik
|
| Genes |
LGR6 (Hs), Lgr6 (Mm), Lgr6 (Rn) |
| Ensembl ID |
ENSG00000133067 (Hs), ENSMUSG00000042793 (Mm), ENSRNOG00000005093 (Rn)
|
| UniProtKB AC |
Q9HBX8 (Hs), Q3UVD5 (Mm)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
|
|
MAS1
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| Nomenclature |
MAS1
|
| Previous and unofficial names |
MGC119966,
MAS,
angiotensin 1-7 receptor [96],
c-mas,
MAS proto-oncogene,
MAS1 oncogene,
angiotensin-(1-7) receptor,
proto-oncogene Mas,
Mas-1
|
| Genes |
MAS1 (Hs), Mas1 (Mm), Mas1 (Rn) |
| Ensembl ID |
ENSG00000130368 (Hs), ENSMUSG00000068037 (Mm), ENSRNOG00000014971 (Rn)
|
| UniProtKB AC |
P04201 (Hs), P30554 (Mm), P12526 (Rn)
|
| Principal transduction |
Gq/G11
|
| Selective agonists |
|
|
|
MAS1L
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More detailed page
| Nomenclature |
MAS1L
|
| Previous and unofficial names |
MAS-L,
MRG,
dJ994E9.2,
MAS-R,
MGC119987,
MAS1 oncogene-like
|
| Genes |
MAS1L (Hs) |
| Ensembl ID |
ENSG00000237284 (Hs)
|
| UniProtKB AC |
P35410 (Hs)
|
| Principal transduction |
-
|
|
|
MRGPRD
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| Nomenclature |
MRGPRD
|
| Previous and unofficial names |
MRGD,
mrgD,
MAS-related GPR, member D,
TGR7,
Beta-alanine receptor,
MRGPRD,
G-protein coupled receptor TGR7,
mas-related G protein-coupled MRGD,
mas-related G-protein coupled receptor member D,
MrgD,
MAS-related G-protein coupled receptor, member D,
MAS-related gene D,
MRGD G protein-coupled receptor,
LOC211578,
Gm499
|
| Genes |
MRGPRD (Hs), Mrgprd (Mm), Mrgprd (Rn) |
| Ensembl ID |
ENSG00000172938 (Hs), ENSMUSG00000051207 (Mm), ENSRNOG00000013448 (Rn)
|
| UniProtKB AC |
Q8TDS7 (Hs), Q91ZB8 (Mm), Q7TN41 (Rn)
|
| Principal transduction |
Gi/Go
|
| Endogenous agonists |
|
| Comment |
An endogenous peptide with a high degree of sequence similarity to angiotensin-(1-7) (AGT, P01019), alamandine, was shown to promote NO release in MrgD-transfected cells. The binding of alamandine to MRGPRD to was shown to be blocked by D-Pro7-angiotensin-(1–7), β-alanine and PD123319 [63]. Genetic ablation of MRGPRD+ neurons of adult mice decreased behavioural sensitivity to mechanical stimuli but not to thermal stimuli [13].
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|
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MRGPRE
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| Nomenclature |
MRGPRE
|
| Previous and unofficial names |
mrgE,
GPR167,
MGC138408,
MRGPRE,
MRGE,
G protein-coupled receptor 167,
G-protein coupled receptor 167,
mas-related G protein-coupled MRGE,
mas-related G-protein coupled receptor member E,
MAS-related GPR, member E,
MAS-related G-protein coupled receptor, member E,
MAS-related gene E,
C130069N09Rik
|
| Genes |
MRGPRE (Hs), Mrgpre (Mm), Mrgpre (Rn) |
| Ensembl ID |
ENSG00000184350 (Hs), ENSMUSG00000048965 (Mm), ENSRNOG00000020735 (Rn)
|
| UniProtKB AC |
Q86SM8 (Hs), Q91ZB7 (Mm), Q7TN40 (Rn)
|
| Principal transduction |
-
|
|
|
MRGPRF
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| Nomenclature |
MRGPRF
|
| Previous and unofficial names |
GPR140,
MGC21621,
mrgF,
MAS-related GPR, member F,
MRGPRF,
GPR168,
RTA,
MRGF,
G protein-coupled receptor 168,
G protein-coupled receptor 140,
Mas-related gene F protein,
G-protein coupled receptor 168,
G-protein coupled receptor 14,
mas-related G protein-coupled MRGF,
seven transmembrane helix receptor,
G protein-coupled receptor MrgF,
mas-related G-protein coupled receptor member F,
LOC266762,
G protein coupled receptor (RTA),
G protein coupled receptor Rca,
G-protein coupled receptor RTA,
MAS-related G-protein coupled receptor, member F,
MAS-related gene F,
BC019711
|
| Genes |
MRGPRF (Hs), Mrgprf (Mm), Mrgprf (Rn) |
| Ensembl ID |
ENSG00000172935 (Hs), ENSMUSG00000031070 (Mm), ENSRNOG00000013426 (Rn)
|
| UniProtKB AC |
Q96AM1 (Hs), Q8VCJ6 (Mm), P23749 (Rn)
|
| Principal transduction |
-
|
| Comment |
MRGPRF has been reported to respond to stimulation by angiotensin metabolites [29].
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|
|
MRGPRG
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| Nomenclature |
MRGPRG
|
| Previous and unofficial names |
MAS-related GPR, member G,
GPR169,
mrgG,
MRGG,
EBRT2,
MRGPRG,
G protein-coupled receptor 169,
G protein-coupled receptor Mrgg,
MAS-related G-protein coupled receptor, member G,
MAS-related gene G,
mas-related G-protein coupled receptor member G,
LOC381974,
Gm1098
|
| Genes |
MRGPRG (Hs), Mrgprg (Mm), Mrgprg (Rn) |
| Ensembl ID |
ENSG00000182170 (Hs), ENSMUSG00000050276 (Mm), ENSRNOG00000020734 (Rn)
|
| UniProtKB AC |
Q86SM5 (Hs), Q91ZB5 (Mm), Q7TN39 (Rn)
|
| Principal transduction |
-
|
|
|
MRGPRX1
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| Nomenclature |
MRGPRX1
|
| Previous and unofficial names |
Mas-related G-protein coupled receptor member X1,
Sensory neuron-specific G-protein coupled receptor 1,
Mrgc,
Mrgprc,
Mrgprc11,
Snsr,
Snsr1,
MRGX1,
SNSR3,
Mrgprb2,
SNSR4,
MRGPRX1,
G protein-coupled receptor MRGX1,
G protein-coupled receptor SNSR3,
MAS-related GPR, member X1,
MrgX1
|
| Genes |
MRGPRX1 (Hs) |
| Ensembl ID |
ENSG00000170255 (Hs)
|
| UniProtKB AC |
Q96LB2 (Hs)
|
| Principal transduction |
Gq/G11
|
| Endogenous agonists |
|
| Comment |
Reported to mediate the sensation of itch [71,108]. Reports that BAM8-22 (PENK, P01210) was the most potent of a series of proenkephalin A–derived peptides as an agonist of MRGPRX1 in assays of calcium mobilisation and radioligand binding [65] were replicated in an independent study using a β-arrestin recruitment assay [110].
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|
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MRGPRX2
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| Nomenclature |
MRGPRX2
|
| Previous and unofficial names |
MRGX2,
Mrgprb10,
MAS-related GPR, member X2,
MrgX2
|
| Genes |
MRGPRX2 (Hs) |
| Ensembl ID |
ENSG00000183695 (Hs)
|
| UniProtKB AC |
Q96LB1 (Hs)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
| Selective agonists |
|
| Comment |
A diverse range of substances has been reported to be agonists of MRGPRX2, with cortistatin 14 the highest potency agonist in assays of calcium mobilisation [99], also confirmed in an independent study using a β-arrestin recruitment assay [110].
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|
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MRGPRX3
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| Nomenclature |
MRGPRX3
|
| Previous and unofficial names |
MrgA,
Mrgpra,
MRGX3,
Mrga10,
SNSR1,
SNSR2,
Sensory neuron-specific G protein-coupled receptor 1/2,
MAS-related GPR, member X3
|
| Genes |
MRGPRX3 (Hs) |
| Ensembl ID |
ENSG00000179826 (Hs)
|
| UniProtKB AC |
Q96LB0 (Hs)
|
| Principal transduction |
Gq/G11
|
|
|
MRGPRX4
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| Nomenclature |
MRGPRX4
|
| Previous and unofficial names |
MGC129753,
MGC129754,
MAS-related GPR, member X4,
SNSR5,
SNSR6,
MRGX4,
Sensory neuron-specific G protein-coupled receptor 5/6,
Sensory neuron-specific G-protein coupled receptor 5/6,
G protein-coupled receptor SNSR5,
G protein-coupled receptor SNSR6,
G protein-coupled receptor MRGX4,
MRGPRX4
|
| Genes |
MRGPRX4 (Hs) |
| Ensembl ID |
ENSG00000179817 (Hs)
|
| UniProtKB AC |
Q96LA9 (Hs)
|
| Principal transduction |
Gq/G11
|
|
|
OPN3
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| Nomenclature |
OPN3
|
| Previous and unofficial names |
Opsin-3,
Encephalopsin,
Panopsin,
ECPN,
ERO,
NMO-1,
LOC498289,
opsin 3,
similar to Opsin-3 (Encephalopsin) (Panopsin)
|
| Genes |
OPN3 (Hs), Opn3 (Mm), Opn3 (Rn) |
| Ensembl ID |
ENSG00000054277 (Hs), ENSMUSG00000026525 (Mm), ENSRNOG00000003778 (Rn)
|
| UniProtKB AC |
Q9H1Y3 (Hs), Q9WUK7 (Mm)
|
| Principal transduction |
-
|
|
|
OPN4
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|
|
OPN5
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| Nomenclature |
OPN5
|
| Previous and unofficial names |
opsin 5,
transmembrane protein 13,
dJ402H5.1,
GPR136,
PGR12,
OPN5,
neuropsin,
PGR14,
G-protein coupled receptor 136,
Transmembrane protein 13,
Neuropsin,
opsin-5,
G-protein coupled receptor PGR12,
TMEM13,
G protein-coupled receptor 136
|
| Genes |
OPN5 (Hs), Opn5 (Mm), Opn5 (Rn) |
| Ensembl ID |
ENSG00000124818 (Hs), ENSMUSG00000043972 (Mm), ENSRNOG00000012689 (Rn)
|
| UniProtKB AC |
Q6U736 (Hs), Q6VZZ7 (Mm), Q7TQN6 (Rn)
|
| Principal transduction |
Gi/Go
|
| Comment |
Evidence indicates OPN5 triggers a UV-sensitive Gi-mediated signalling pathway in mammalian tissues [57].
|
|
|
P2RY8
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| Nomenclature |
P2RY8
|
| Previous and unofficial names |
purinergic receptor P2Y, G-protein coupled, 8,
P2Y8,
MGC50878,
P2RY8,
G-protein coupled purinergic receptor P2Y8,
purinergic receptor P2Y,
G-protein coupled, 8,
P2Y purinoceptor 8
|
| Genes |
P2RY8 (Hs) |
| Ensembl ID |
ENSG00000182162 (Hs)
|
| UniProtKB AC |
Q86VZ1 (Hs)
|
| Principal transduction |
-
|
|
|
P2RY10
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| Nomenclature |
P2RY10
|
| Previous and unofficial names |
purinergic receptor P2Y, G-protein coupled, 10,
P2Y-like receptor,
P2Y10,
purinergic receptor,
P2Y-like,
LOC317219,
MGC189289,
P2ry10_predicted,
RGD1561912,
RGD1561912_predicted,
purinergic receptor P2Y, G-protein coupled 10 ,
purinergic receptor P2Y, G-protein coupled 10 (predicted),
similar to purinergic receptor P2Y, G-protein coupled 10,
similar to purinergic receptor P2Y, G-protein coupled 10 (predicted),
5830408N17Rik
|
| Genes |
P2RY10 (Hs), P2ry10 (Mm), P2ry10 (Rn) |
| Ensembl ID |
ENSG00000078589 (Hs), ENSMUSG00000050921 (Mm), ENSRNOG00000037839 (Rn)
|
| UniProtKB AC |
O00398 (Hs), Q7TMT1 (Mm)
|
| Principal transduction |
-
|
| Endogenous agonists |
|
|
|
TAAR2
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| Nomenclature |
TAAR2
|
| Previous and unofficial names |
GPR58,
TA2,
trace amine associated receptor 2,
TAA2,
G protein-coupled receptor 58,
Gpr58_predicted,
LOC294121,
Taar2,
G protein-coupled receptor 58 (predicted),
G-protein coupled receptor 58,
taR-2,
trace amine receptor 2,
trace amine-associated receptor 2,
Gm225
|
| Genes |
TAAR2 (Hs), Taar2 (Mm), Taar2 (Rn) |
| Ensembl ID |
ENSG00000146378 (Hs), ENSMUSG00000059763 (Mm), ENSRNOG00000025951 (Rn)
|
| UniProtKB AC |
Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn)
|
| Principal transduction |
Gs
|
|
Rank order of potency
|
β-phenylethylamine > tryptamine
[8]
|
| Comment |
Probable pseudogene in 10–15% of Asians due to a polymorphism (rs8192646) producing a premature stop codon at amino acid 168 [20].
|
|
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TAAR3
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| Nomenclature |
TAAR3
|
| Previous and unofficial names |
trace amine associated receptor 3,
GPR57,
G protein-coupled receptor 57,
taR-3,
trace amine receptor 3,
trace amine-associated receptor 3
|
| Genes |
TAAR3 (Hs), Taar3 (Mm), Taar3 (Rn) |
| Ensembl ID |
ENSG00000179073 (Hs), ENSMUSG00000069708 (Mm), ENSRNOG00000025982 (Rn)
|
| UniProtKB AC |
Q9P1P4 (Hs), Q5QD16 (Mm), Q5QD24 (Rn)
|
| Principal transduction |
-
|
| Comment |
TAAR3 is thought to be a pseudogene in man though functional in rodents [20]
|
|
|
TAAR4P
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| Nomenclature |
TAAR4P
|
| Previous and unofficial names |
trace amine receptor 2,
taR-4,
Ta2,
taR-2,
trace amine receptor 4,
trace amine-associated receptor 4,
trace-amine-associated receptor 4,
Gm226
|
| Genes |
TAAR4P (Hs), Taar4 (Mm), Taar4 (Rn) |
| Ensembl ID |
ENSG00000237449 (Hs), ENSMUSG00000069707 (Mm), ENSRNOG00000029877 (Rn)
|
| UniProtKB AC |
Q5QD15 (Mm), Q923Y7 (Rn)
|
| Principal transduction |
Gs
|
| Comment |
Pseudogene in man but functional in rodents [20].
|
|
|
TAAR5
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| Nomenclature |
TAAR5
|
| Previous and unofficial names |
Putative neurotransmitter receptor,
PNR,
MGC138414,
MGC138416,
RP11-295F4.5,
TAAR5,
Trace amine receptor,
Trace amine receptor 5,
trace amine-associated receptor 5,
TaR-5,
trace amine associated receptor 5,
LOC215854,
Gm227
|
| Genes |
TAAR5 (Hs), Taar5 (Mm), Taar5 (Rn) |
| Ensembl ID |
ENSG00000135569 (Hs), ENSMUSG00000069706 (Mm), ENSRNOG00000039869 (Rn)
|
| UniProtKB AC |
O14804 (Hs), Q5QD14 (Mm), Q5QD23 (Rn)
|
| Principal transduction |
-
|
|
|
TAAR6
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More detailed page
| Nomenclature |
TAAR6
|
| Previous and unofficial names |
Trace amine-associated receptor 6,
Trace amine receptor 4,
TaR-4,
TA4,
TAR4,
TRAR4,
RP11-295F4.3,
SCZD5,
TAAR6,
TA4,
taR-6,
trace amine receptor 6,
trace-amine-associated receptor 6,
LOC215855,
Gm228
|
| Genes |
TAAR6 (Hs), Taar6 (Mm), Taar6 (Rn) |
| Ensembl ID |
ENSG00000146383 (Hs), ENSMUSG00000045111 (Mm), ENSRNOG00000016089 (Rn)
|
| UniProtKB AC |
Q96RI8 (Hs), Q5QD13 (Mm), Q923Y5 (Rn)
|
| Principal transduction |
-
|
|
|
TAAR8
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More detailed page
| Nomenclature |
TAAR8
|
| Previous and unofficial names |
trace amine associated receptor 8,
trace amine receptor 5,
TA5,
TAR5,
GPR102,
TRAR5,
TA11,
TAR11,
TRAR11,
Gm1149,
taR-11,
taR-8a,
trace amine receptor 11,
trace amine receptor 8a,
trace amine-associated receptor 8a,
trace-amine-associated receptor 8a,
LOC215859,
Gm230
|
| Genes |
TAAR8 (Hs), Taar8a (Mm), Taar8a (Rn) |
| Ensembl ID |
ENSG00000146385 (Hs), ENSMUSG00000050804 (Mm), ENSRNOG00000030414 (Rn)
|
| UniProtKB AC |
Q969N4 (Hs), Q5QD06 (Mm), Q923X9 (Rn)
|
| Principal transduction |
-
|
|
|
TAAR9
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More detailed page
| Nomenclature |
TAAR9
|
| Previous and unofficial names |
trace amine-associated receptor 9,
TA3,
TAR3,
TRAR3,
trace amine receptor 3,
trace amine associated receptor 9,
taR-3,
taR-9,
trace amine receptor 9,
trace-amine-associated receptor 9,
Gm231
|
| Genes |
TAAR9 (Hs), Taar9 (Mm), Taar9 (Rn) |
| Ensembl ID |
ENSG00000237110 (Hs), ENSMUSG00000037424 (Mm), ENSRNOG00000026096 (Rn)
|
| UniProtKB AC |
Q96RI9 (Hs), Q5QD04 (Mm), Q923Y6 (Rn)
|
| Principal transduction |
-
|
| Comment |
TAAR9 appears to be functional in most individuals but has a polymorphic premature stop codon at amino acid 61 (rs2842899) with an allele frequency of 10–30% in different populations [119].
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