BPS/IUPHAR Guide to Pharmacology | GRAC TRANSPORTER FAMILIES

F-type and V-type ATPases

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F-type ATPase
V-type ATPase

The F-type (ATP synthase) and the V-type (vacuolar or vesicular proton pump) ATPases, although having distinct subcellular locations and roles, exhibit marked similarities in subunit structure and mechanism. They are both composed of a ‘soluble’ complex (termed F₁ or V₁) and a membrane complex (F_o or V_o). Within each ATPase complex, the two individual sectors appear to function as connected opposing rotary motors, coupling catalysis of ATP synthesis or hydrolysis to proton transport. Both the F-type and V-type ATPases have been assigned enzyme commission number E.C. 3.6.3.14

F-type ATPase

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The F-type ATPase, also known as ATP synthase or ATP phosphohydrolase (H⁺-transporting), is a mitochondrial membrane-associated multimeric complex consisting of two domains, an F₀ channel domain in the membrane and an F₁ domain extending into the lumen. Proton transport across the inner mitochondrial membrane is used to drive the synthesis of ATP, although it is also possible for the enzyme to function as an ATPase. The ATP5O subunit (oligomycin sensitivity-conferring protein, OSCP, ENSG00000241837), which acts as a connector between F₁ and F₀ motors.

The F₁ motor, responsible for ATP turnover, has the subunit composition α3β3γδε.

The F₀ motor, responsible for ion translocation, is complex in mammals, with probably nine subunits centring on A, B, and C subunits in the membrane, together with D, E, F2, F6, G2 and 8 subunits. Multiple pseudogenes for the F₀ motor proteins have been defined in the human genome.

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

α Show »« Hide

Nomenclature	α
Other names	ATP5A, ATP5AL2, ATPM, hATP1, OMR, ORM, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle, ATP synthase subunit alpha, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, mitochondrial H+-ATP synthase alpha subunit, D18Ertd206e, Mom2, atp synthase, h+ transporting, mitochondrial f1 complex, alpha subunit, isoform 1
Genes	ATP5A1 (Hs), Atp5a1 (Mm), Atp5a1 (Rn)
Ensembl ID	ENSG00000152234 (Hs), ENSMUSG00000025428 (Mm), ENSRNOG00000017032 (Rn)

β Show »« Hide

Nomenclature	β
Other names	ATPSB, ATP synthase subunit beta, mitochondrial, ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit, mitochondrial ATP synthase beta subunit
Genes	ATP5B (Hs), Atp5b (Mm), Atp5b (Rn)
Ensembl ID	ENSG00000110955 (Hs), ENSMUSG00000025393 (Mm), ENSRNOG00000002840 (Rn)

γ Show »« Hide

Nomenclature	γ
Other names	ATP5C, ATP5CL1, ATP synthase subunit gamma, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, F-ATPase gamma subunit, F1 gamma
Genes	ATP5C1 (Hs), Atp5c1 (Mm), Atp5c1 (Rn)
Ensembl ID	ENSG00000165629 (Hs), ENSMUSG00000025781 (Mm), ENSRNOG00000019223 (Rn)

δ Show »« Hide

Nomenclature	δ
Other names	ATP synthase subunit delta, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, F-ATPase delta subunit
Genes	ATP5D (Hs), Atp5d (Mm), Atp5d (Rn)
Ensembl ID	ENSG00000099624 (Hs), ENSMUSG00000003072 (Mm), ENSRNOG00000014625 (Rn)

ε Show »« Hide

Nomenclature	ε
Other names	ATP synthase subunit epsilon, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit, ATPase subunit epsilon
Genes	ATP5E (Hs), Atp5e (Mm), Atp5e (Rn)
Ensembl ID	ENSG00000124172 (Hs), ENSMUSG00000016252 (Mm), ENSRNOG00000025873 (Rn)

A Show »« Hide

Nomenclature	A
Other names	F-ATPase protein 6, MTATP6, RP, ATP6, ATPase-6, Su6m, ATP synthase 6, spicular retinitis pigmentosa with dementia, seizures, ataxia, proximal muscle weakness and sensory deficit, ATP synthase 6, mitochondrial, ATP synthase F0 subunit 6, ATPase subunit 6, ATPASE6
Genes	MT-ATP6 (Hs), mt-Atp6 (Mm), Mt-atp6 (Rn)
Ensembl ID	ENSG00000198899 (Hs), ENSMUSG00000064357 (Mm), ENSRNOG00000031979 (Rn)

B Show »« Hide

Nomenclature	B
Other names	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1, ATP synthase subunit b, mitochondrial, ATPase subunit b, C76477
Genes	ATP5F1 (Hs), Atp5f1 (Mm), Atp5f1 (Rn)
Ensembl ID	ENSG00000116459 (Hs), ENSMUSG00000000563 (Mm), ENSRNOG00000016000 (Rn)

C Show »« Hide

Nomenclature	C
Other names	ATP5G, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9), ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9), ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9), ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9) isoform 1, ATP synthase lipid-binding protein, mitochondrial, ATP synthase proteolipid P1, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 , ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1, ATPase protein 9, ATPase subunit c, ATP synthase proteolipid P3, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 3, ATP synthase proteolipid P2
Genes	ATP5G1 (Hs), ATP5G2 (Hs), ATP5G3 (Hs), Atp5g2 (Mm), Atp5g3 (Mm), Atp5g1 (Mm), Atp5g3 (Rn), Atp5g1 (Rn), Atp5g2 (Rn)
Ensembl ID	ENSG00000135390 (Hs), ENSG00000154518 (Hs), ENSG00000159199 (Hs), ENSMUSG00000006057 (Mm), ENSMUSG00000018770 (Mm), ENSMUSG00000062683 (Mm), ENSRNOG00000001596 (Rn), ENSRNOG00000007235 (Rn), ENSRNOG00000015320 (Rn)

D Show »« Hide

Nomenclature	D
Other names	ATP5JD, ATPQ, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d, ATP synthase subunit d, ATP synthase subunit d, mitochondrial, ATPase subunit d
Genes	ATP5H (Hs), Atp5h (Mm), Atp5h (Rn)
Ensembl ID	ENSG00000167863 (Hs), ENSMUSG00000034566 (Mm), ENSRNOG00000003626 (Rn)

E Show »« Hide

Nomenclature	E
Other names	ATP5K, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e, ATP synthase subunit e, mitochondrial, ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e, ATPase subunit e, Lfm1
Genes	ATP5I (Hs), Atp5k (Mm), Atp5i (Rn)
Ensembl ID	ENSG00000169020 (Hs), ENSMUSG00000050856 (Mm), ENSRNOG00000000064 (Rn)

F2 Show »« Hide

Nomenclature	F2
Other names	ATP5JL, F1Fo-ATPase, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2, F1Fo-ATPase synthase f subunit, ATP synthase f chain, mitochondrial, F1Fo-ATP synthase complex Fo membrane domain f subunit, LOC690441, ATP synthase subunit f, mitochondrial, ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2, similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2, hypothetical protein, clone:2-31
Genes	ATP5J2 (Hs), Atp5j2 (Mm), Atp5j2 (Rn)
Ensembl ID	ENSG00000241468 (Hs), ENSMUSG00000038690 (Mm), ENSRNOG00000027049 (Rn)

F6 Show »« Hide

Nomenclature	F6
Other names	ATP5, ATP5A, ATPM, CF6, ATP synthase-coupling factor 6, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6, coupling factor 6, ATP synthase-coupling factor 6, mitochondrial, ATPase subunit F6
Genes	ATP5J (Hs), Atp5j (Mm), Atp5j (Rn)
Ensembl ID	ENSG00000154723 (Hs), ENSMUSG00000022890 (Mm), ENSRNOG00000001551 (Rn)

G2 Show »« Hide

Nomenclature	G2
Other names	ATP5K2, dJ222E13.5, ATP synthase, H+ transporting, mitochondrial F1F0, subunit g, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, isoform 2, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G2 pseudogene, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G2, OTTMUSG00000002778
Genes	ATP5L2 (Hs), Atp5l2 (Mm)
Ensembl ID	ENSG00000249222 (Hs), ENSMUSG00000084168 (Mm)

8 Show »« Hide

V-type ATPase

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The V-type ATPase is most prominently associated with lysosomes in mammals, but also appears to be expressed on the plasma membrane and neuronal synaptic vesicles.

The V₁ motor, responsible for ATP turnover, has eight subunits with a composition of A-H.

The V_o motor, responsible for ion translocation, has six subunits (a-e).

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

A Show »« Hide

Nomenclature	A
Other names	ATP6A1, ATP6V1A1, VA68, Vma1, VPP2, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD, isoform 1, LOC685232, ATPase, H+ transporting, lysosomal V1 subunit A, V-type proton ATPase catalytic subunit A, similar to ATPase, H+ transporting, V1 subunit A, isoform 1, lysosomal 70kDa
Genes	ATP6V1A (Hs), Atp6v1a (Mm), Atp6v1a (Rn)
Ensembl ID	ENSG00000114573 (Hs), ENSMUSG00000052459 (Mm), ENSRNOG00000001992 (Rn)

B1 Show »« Hide

Nomenclature	B1
Other names	ATP6B1, RTA1B, VATB, Vma2, VPP3, vacuolar proton pump 3, Renal tubular acidosis with deafness, Atp6v1b1_predicted, LOC312488, ATPase, H transporting, lysosomal V1 subunit B1, ATPase, H transporting, lysosomal V1 subunit B1 (predicted), ATPase, H+ transporting, V1 subunit B, isoform 1, ATPase, H+ transporting, V1 subunit B, isoform 1 (predicted), V-type proton ATPase subunit B, kidney isoform, Vpp-3, lysosomal 56/58kDa
Genes	ATP6V1B1 (Hs), Atp6v1b1 (Mm), Atp6v1b1 (Rn)
Ensembl ID	ENSG00000116039 (Hs), ENSMUSG00000006269 (Mm), ENSRNOG00000013573 (Rn)

B2 Show »« Hide

Nomenclature	B2
Other names	ATP6B2, HO57, VATB, Vma2, VPP3, ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide, 56/58kD, isoform 2, ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2, Atp6b1b2, ATPase, H+ transporting, V1 subunit B, isoform 2, ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2, V-ATPase, V-ATPase subunit B 2, V-type proton ATPase subunit B, brain isoform, endomembrane proton pump 58 kDa subunit, vacuolar H+ATPase B2, vacuolar proton pump subunit B 2
Genes	ATP6V1B2 (Hs), Atp6v1b2 (Mm), Atp6v1b2 (Rn)
Ensembl ID	ENSG00000147416 (Hs), ENSMUSG00000006273 (Mm), ENSRNOG00000011891 (Rn)

C1 Show »« Hide

Nomenclature	C1
Other names	ATP6C, ATP6D, VATC, Vma5, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 42kD, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1, V-ATPase subunit C 1, Atp6v1c1_predicted, LOC299971, MGC109315, ATPase, H+ transporting, V1 subunit C, isoform 1, ATPase, H+ transporting, V1 subunit C, isoform 1 (predicted), ATPase, H+ transporting, lysosomal V1 subunit C1, V-type proton ATPase subunit C 1, vacuolar proton pump subunit C 1
Genes	ATP6V1C1 (Hs), Atp6v1c1 (Mm), Atp6v1c1 (Rn)
Ensembl ID	ENSG00000155097 (Hs), ENSMUSG00000022295 (Mm), ENSRNOG00000004846 (Rn)

C2 Show »« Hide

Nomenclature	C2
Other names	ATP6C2, VMA5, ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2, LOC362802, ATPase, H+ transporting, V1 subunit C, isoform 2, V-ATPase subunit C 2, V-type ATPase C2 subunit a isoform, V-type proton ATPase subunit C 2, similar to RIKEN cDNA 1110038G14, vacuolar H+ ATPase C2, vacuolar proton pump subunit C 2
Genes	ATP6V1C2 (Hs), Atp6v1c2 (Mm), Atp6v1c2 (Rn)
Ensembl ID	ENSG00000143882 (Hs), ENSMUSG00000020566 (Mm)

D Show »« Hide

Nomenclature	D
Other names	ATP6M, VATD, VMA8, ATPase, H+ transporting, lysosomal (vacuolar proton pump), ATPase, H+ transporting, V1 subunit D, ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D, ATPase, H+ transporting, lysosomal V1 subunit D, V-type proton ATPase subunit D, lysosomal 34kDa
Genes	ATP6V1D (Hs), Atp6v1d (Mm), Atp6v1d (Rn)
Ensembl ID	ENSG00000100554 (Hs), ENSMUSG00000021114 (Mm), ENSRNOG00000009080 (Rn)

E1 Show »« Hide

Nomenclature	E1
Other names	ATP6E, ATP6E2, ATP6V1E, P31, Vma4, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD, ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1, MGC72933, ATPase, H+ transporting, V1 subunit E, ATPase, H+ transporting, V1 subunit E isoform 1, ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E, V-ATPase subunit E 1, V-type proton ATPase subunit E 1, VATPase, H+ transporting, lysosomal V1 subunit E1, vacuolar H(+)-ATPase, E subunit, vacuolar H+ ATPase E1, vacuolar proton pump subunit E 1, H+ ATPase subunit E, H(+)-ATPase E-like protein, E2, lysosomal 31kDa, D6Ertd385e
Genes	ATP6V1E1 (Hs), Atp6v1e1 (Mm), Atp6v1e1 (Rn)
Ensembl ID	ENSG00000131100 (Hs), ENSMUSG00000019210 (Mm), ENSRNOG00000011905 (Rn)

E2 Show »« Hide

Nomenclature	E2
Other names	ATP6E1, ATP6EL2, ATP6V1EL2, MGC9341, VMA4, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD-like 2, ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 2, Atp6v1e2_predicted, LOC366545, ATPase, H transporting, lysosomal V1 subunit E2, ATPase, H transporting, lysosomal V1 subunit E2 (predicted), ATPase, H+ transporting, V1 subunit E-like 2, ATPase, H+ transporting, V1 subunit E-like 2 isoform 2 (predicted), V-type proton ATPase subunit E 2, E1, lysosomal 31kDa
Genes	ATP6V1E2 (Hs), Atp6v1e2 (Mm), Atp6v1e2 (Rn)
Ensembl ID	ENSG00000250565 (Hs), ENSMUSG00000053375 (Mm), ENSRNOG00000015566 (Rn)

F Show »« Hide

Nomenclature	F
Other names	ATP6S14, VATF, Vma7, ATPase, H transporting, lysosomal V1 subunit F, ATPase, H+ transporting, V1 subunit F, ATPase, vacuolar, 14 kD, V-ATPase 14 kDa subunit, V-ATPase subunit F, V-type proton ATPase subunit F, vacuolar proton pump subunit F
Genes	ATP6V1F (Hs), Atp6v1f (Mm), Atp6v1f (Rn)
Ensembl ID	ENSG00000128524 (Hs), ENSMUSG00000004285 (Mm), ENSRNOG00000007392 (Rn)

G1 Show »« Hide

Nomenclature	G1
Other names	ATP6G, ATP6G1, ATP6GL, ATP6J, DKFZp547P234, Vma10, ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J, ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1, Atp6v1g1_predicted, LOC298103, ATPase, H transporting, lysosomal V1 subunit G1, ATPase, H transporting, lysosomal V1 subunit G1 (predicted), ATPase, H+ transporting, V1 subunit G, ATPase, H+ transporting, V1 subunit G isoform 1 (predicted), V-type proton ATPase subunit G 1, VAG1, lysosomal 13kDa
Genes	ATP6V1G1 (Hs), Atp6v1g1 (Mm), Atp6v1g1 (Rn)
Ensembl ID	ENSG00000136888 (Hs), ENSMUSG00000039105 (Mm), ENSRNOG00000008163 (Rn)

G2 Show »« Hide

Nomenclature	G2
Other names	ATP6G, ATP6G2, Em:AC004181.3, NG38, Vma10, ATPase, H+ transporting, lysosomal (vacuolar proton pump), ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2, ATPase, H+ transporting, V1 subunit G, ATPase, H+ transporting, V1 subunit G isoform 2, V-type proton ATPase subunit G 2, vacuolar ATPase NG38, VAG2, lysosomal 13kDa
Genes	ATP6V1G2 (Hs), Atp6v1g2 (Mm), Atp6v1g2 (Rn)
Ensembl ID	ENSG00000213760 (Hs), ENSMUSG00000024403 (Mm), ENSRNOG00000000840 (Rn)

G3 Show »« Hide

Nomenclature	G3
Other names	ATP6G3, Vma10, ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3, ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 3, Atp6v1g3_predicted, LOC289407, ATPase, H transporting, lysosomal V1 subunit G3 , ATPase, H transporting, lysosomal V1 subunit G3 (predicted), ATPase, H+ transporting, V1 subunit G, isoform 3, ATPase, H+ transporting, V1 subunit G, isoform 3 (predicted), ATPase, H+ transporting, lysosomal V1 subunit G3, V-type proton ATPase subunit G 3
Genes	ATP6V1G3 (Hs), Atp6v1g3 (Mm), Atp6v1g3 (Rn)
Ensembl ID	ENSG00000151418 (Hs), ENSMUSG00000026394 (Mm), ENSRNOG00000022480 (Rn)

H Show »« Hide

Nomenclature	H
Other names	CGI-11, SFD, SFDalpha, SFDbeta, VMA13, ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H, vacuolar ATP synthase subunit H, ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, ATPase, H+ transporting, lysosomal V1 subunit H, V-ATPase H subunit, V-type proton ATPase subunit H, vacuolar ATPase subunit H, vacuolar proton pump H subunit
Genes	ATP6V1H (Hs), Atp6v1h (Mm), Atp6v1h (Rn)
Ensembl ID	ENSG00000047249 (Hs), ENSMUSG00000033793 (Mm), ENSRNOG00000030862 (Rn)

a1 Show »« Hide

Nomenclature	a1
Other names	ATP6N1, ATP6N1A, Stv1, Vph1, VPP1, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD), ATPase, H+ transporting, lysosomal V0 subunit a isoform 1, ATPase, H+ transporting, lysosomal V0 subunit A1, ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa), ATPase H+ transporting lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa), ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a, ATPase, H+ transporting, lysosomal V0 subunit a, ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a, V-ATPase 116 kDa, V-type proton ATPase 116 kDa subunit a, V-type proton ATPase 116 kDa subunit a isoform 1, clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, v-H+ATPase subunit a1, vacuolar adenosine triphosphatase subunit Ac116, vacuolar proton pump subunit 1, vacuolar proton translocating ATPase 116 kDa subunit a, V-ATPase a1, Vpp-1
Genes	ATP6V0A1 (Hs), Atp6v0a1 (Mm), Atp6v0a1 (Rn)
Ensembl ID	ENSG00000033627 (Hs), ENSMUSG00000019302 (Mm)

a2 Show »« Hide

Nomenclature	a2
Other names	ATP6a2, ATP6N1D, J6B7, Stv1, TJ6, TJ6M, TJ6s, Vph1, infantile malignant osteopetrosis, ATPase, H+ transporting, lysosomal V0 subunit a isoform 2, ATPase, H+ transporting, lysosomal V0 subunit A2, Atp6v0a2_predicted, Cc1-3, LOC304467, ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 (predicted), T-cell expressing clone j6, V-type proton ATPase 116 kDa subunit a, V-type proton ATPase 116 kDa subunit a isoform 2, Atp6n2, V-ATPase a2
Genes	ATP6V0A2 (Hs), Atp6v0a2 (Mm), Atp6v0a2 (Rn)
Ensembl ID	ENSG00000185344 (Hs), ENSMUSG00000038023 (Mm), ENSRNOG00000001019 (Rn)

a3 Show »« Hide

Nomenclature	a3
Other names	T-cell immune regulator 1, Atp6i, ATP6N1C, ATP6V0A3, OC-116, OC116, TIRC7, T-cell, immune regulator 1, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3, T-cell immune response cDNA 7, MGC72583, ATPase, H+ transporting, lysosomal V0 protein a, T cell immune response cDNA7 protein, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, V-type proton ATPase 116 kDa subunit a, V-type proton ATPase 116 kDa subunit a isoform 3, osteoclastic proton pump, v-ATPase 116-kDa, v-H+ATPase subunit a3, V-ATPase a3, ATP6a3
Genes	TCIRG1 (Hs), Tcirg1 (Mm), Tcirg1 (Rn)
Ensembl ID	ENSG00000110719 (Hs), ENSMUSG00000001750 (Mm), ENSRNOG00000017220 (Rn)

a4 Show »« Hide

Nomenclature	a4
Other names	ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, Stv1, Vph1, VPP2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B, ATPase, H+ transporting, lysosomal V0 subunit a isoform 4, ATPase, H+ transporting, lysosomal V0 subunit A4, Atp6v0a4_predicted, LOC296981, ATPase, H+ transporting, lysosomal V0 subunit A, ATPase, H+ transporting, lysosomal V0 subunit A isoform 4 (predicted), V-type proton ATPase 116 kDa subunit a, V-type proton ATPase 116 kDa subunit a isoform 4, V-ATPase alpha 4
Genes	ATP6V0A4 (Hs), Atp6v0a4 (Mm), Atp6v0a4 (Rn)
Ensembl ID	ENSG00000105929 (Hs), ENSMUSG00000038600 (Mm), ENSRNOG00000013428 (Rn)

b Show »« Hide

Nomenclature	b
Other names	ATP6F, HATPL, VMA16, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD, ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'', Atp6v0b_predicted, LOC298451, ATPase, H+ transporting, V0 subunit B, ATPase, H+ transporting, V0 subunit B (predicted), ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b, V-type proton ATPase 21 kDa proteolipid subunit
Genes	ATP6V0B (Hs), Atp6v0b (Mm), Atp6v0b (Rn)
Ensembl ID	ENSG00000117410 (Hs), ENSMUSG00000033379 (Mm), ENSRNOG00000019655 (Rn)

c Show »« Hide

Nomenclature	c
Other names	ATP6C, ATP6L, ATPL, VATL, Vma3, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD, ATPase, H transporting, lysosomal V0 subunit c, ATPase, H+ transporting, V0 subunit C, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit C, ATPase, H+ transporting, lysosomal 1, ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c, V-ATPase 16 kDa proteolipid subunit, V-type proton ATPase 16 kDa proteolipid subunit, vacuolar proton pump 16 kDa proteolipid subunit, proteolipid, PL16, H(+)-ATPase (mvp), Atpl-rs1, Atp6c2
Genes	ATP6V0C (Hs), Atp6v0c (Mm), Atp6v0c (Rn)
Ensembl ID	ENSG00000185883 (Hs), ENSMUSG00000024121 (Mm), ENSRNOG00000006542 (Rn)

d1 Show »« Hide

Nomenclature	d1
Other names	ATP6D, ATP6DV, P39, VATX, Vma6, VPATPD, ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1, Atp6v0d1_predicted, LOC291969, ATPase, H+ transporting, V0 subunit D, ATPase, H+ transporting, V0 subunit D isoform 1, ATPase, H+ transporting, V0 subunit D isoform 1 (predicted), V-type proton ATPase subunit d 1, Ac39, lysosomal 38kDa
Genes	ATP6V0D1 (Hs), Atp6v0d1 (Mm), Atp6v0d1 (Rn)
Ensembl ID	ENSG00000159720 (Hs), ENSMUSG00000013160 (Mm), ENSRNOG00000017235 (Rn)

d2 Show »« Hide

Nomenclature	d2
Other names	ATP6D2, FLJ38708, VMA6, ATPase, H+ transporting, lysosomal 38kD, V0 subunit d isoform 2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D2, Atp6v0d2_predicted, LOC297932, MGC109196, ATPase, H+ transporting, V0 subunit D, isoform 2, ATPase, H+ transporting, V0 subunit D, isoform 2 (predicted), V-ATPase subunit d 2, V-type proton ATPase subunit d 2, vacuolar proton pump subunit d 2
Genes	ATP6V0D2 (Hs), Atp6v0d2 (Mm), Atp6v0d2 (Rn)
Ensembl ID	ENSG00000147614 (Hs), ENSMUSG00000028238 (Mm), ENSRNOG00000006926 (Rn)

e1 Show »« Hide

Nomenclature	e1
Other names	ATP6H, ATP6V0E, M9.2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9kD, ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e, Atp6k, Dsr-1A, dsr-1, ATPase, H+ transporting, V0 subunit, ATPase, H+ transporting, V0 subunit E, ATPase, H+ transporting, V0 subunit E isoform 1, ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1, ATPase, H+ transporting, lysosomal V0 subunit E1, D-serine-regulated transcript 1 protein, V-ATPase 9.2 kDa membrane accessory protein, V-ATPase M9.2 subunit, V-ATPase subunit e 1, V-type proton ATPase subunit e 1, vacuolar proton pump subunit e 1, vacuolar proton-ATPase subunit M9.2, lysosomal 9kDa
Genes	ATP6V0E1 (Hs), Atp6v0e (Mm), Atp6v0e1 (Rn)
Ensembl ID	ENSG00000113732 (Hs), ENSMUSG00000015575 (Mm), ENSRNOG00000003269 (Rn)

e2 Show »« Hide

Nomenclature	e2
Other names	ATP6V0E2L, C7orf32, chromosome 7 open reading frame 32, ATPase, H+ transporting V0 subunit E isoform 2-like (rat), NM9.2, ATPase, H+ transporting, V0 subunit, ATPase, H+ transporting, V0 subunit E, ATPase, H+ transporting, V0 subunit E isoform 2, ATPase, H+ transporting, lysosomal V0 subunit E2, V-ATPase subunit e 2, V-type proton ATPase subunit e 2, vacuolar proton pump subunit e 2
Genes	ATP6V0E2 (Hs), Atp6v0e2 (Mm), Atp6v0e2 (Rn)
Ensembl ID	ENSG00000171130 (Hs), ENSMUSG00000039347 (Mm), ENSRNOG00000008218 (Rn)