SLC22 family of organic cation and anion transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC22 family of transporters is mostly composed of non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role in drug disposition. The family may be divided into three subfamilies based on the nature of the substrate transported: organic cations (OCTs), organic anions (OATs) and organic zwiterrion/cations (OCTN). Membrane topology is predicted to contain 12 TM domains with intracellular termini, and an extended extracellular loop at TM 1/2.

Organic cation transporters (OCT)

Overview

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Organic cation transporters (OCT) are electrogenic, Na+-independent and reversible.

Transporters

OCT1 (Organic cation transporter 1 / SLC22A1) Show summary »

OCT2 (Organic cation transporter 2 / SLC22A2) Show summary »

OCT3 (Organic cation transporter 3 / SLC22A3) Show summary »

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Organic zwitterions/cation transporters (OCTN)

Overview

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Organic zwitterions/cation transporters (OCTN) function as organic cation uniporters, organic cation/proton exchangers or sodium/L-carnitine co-transporters.

Transporters

OCTN1 (Organic cation/carnitine transporter 1 / SLC22A4) Show summary »

OCTN2 (Organic cation/carnitine transporter 2 / SLC22A5) Show summary »

CT2 (Carnitine transporter 2 / SLC22A16) Show summary »

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Organic anion transporters (OATs)

Overview

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Organic anion transporters (OATs) are non-selective transporters prominent in the kidney and intestine

Transporters

OAT1 (Organic anion transporter 1 / SLC22A6) Show summary » More detailed page

OAT2 (Organic anion transporter 2 / SLC22A7) Show summary »

OAT3 (Organic anion transporter 3 / SLC22A8) Show summary » More detailed page

OAT4 (Organic anion transporter 7 / SLC22A9) Show summary »

OAT5 (Organic anion transporter 5 / SLC22A10) Show summary »

Organic anion transporter 4 / SLC22A11 Show summary » More detailed page

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Urate transporter

Transporters

URAT1 (Urate anion exchanger 1 / SLC22A12) Show summary »

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Orphan or poorly characterized SLC22 family members

Transporters

ORCTL3 (Organic cation transporter-like 3 / SLC22A13) Show summary »

ORCTL4 (Organic cation transporter-like 4 / SLC22A14) Show summary »

FLIPT1 (Fly-like putative transporter 1 / SLC22A15) Show summary »

BOIT (Brain-type organic cation transporter / SLC22A17) Show summary »

ORCTL2 (Organic cation transporter-like 2 / SLC22A18) Show summary »

OAT6 / SLC22A20 Show summary »

SLC22A23 Show summary »

SLC22A24 Show summary »

UST6 / SLC22A25 Show summary »

solute carrier family 22, member 31 / SLC22A31 Show summary »

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Further reading

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References

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