Organic cation transporters (OCT) are electrogenic, Na⁺-independent and reversible.

Corticosterone and quinine are able to inhibit all three organic cation transporters.

* Key recommended reading is highlighted with an asterisk

Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med, 34 (2-3): 413-35. [PMID:23506881]

* Koepsell H. (2020) Organic Cation Transporters in Health and Disease. Pharmacol Rev, 72 (1): 253-319. [PMID:31852803]

* Lozano E, Herraez E, Briz O, Robledo VS, Hernandez-Iglesias J, Gonzalez-Hernandez A, Marin JJ. (2013) Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology. Biomed Res Int, 2013: 692071. [PMID:23984399]

* Pelis RM, Wright SH. (2014) SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties. Curr Top Membr, 73: 233-61. [PMID:24745985]

* Samodelov SL, Kullak-Ublick GA, Gai Z, Visentin M. (2020) Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology. Int J Mol Sci, 21 (21). [PMID:33114309]

* Yee SW, Giacomini KM. (2021) Emerging Roles of the Human Solute Carrier 22 Family. Drug Metab Dispos, 50 (9): 1193-210. [PMID:34921098]

* Yin J, Wang J. (2016) Renal drug transporters and their significance in drug-drug interactions. Acta Pharm Sin B, 6 (5): 363-373. [PMID:27709005]

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5. Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med, 34 (2-3): 413-35. [PMID:23506881]

6. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG et al.. (2007) Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest, 117 (5): 1422-31. [PMID:17476361]

7. Zhang L, Schaner ME, Giacomini KM. (1998) Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther, 286 (1): 354-61. [PMID:9655880]

8. Zhu HJ, Appel DI, Gründemann D, Markowitz JS. (2010) Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem, 114 (1): 142-9. [PMID:20402963]