PGE2

Ligand id: 1883

Name: PGE2

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 12
Topological polar surface area 94.83
Molecular weight 352.22
XLogP 2.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Metabolite or derivative
Approved drug? Yes (source: FDA (1977))
IUPAC Name
(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
International Nonproprietary Names
INN number INN
3075 dinoprostone
Synonyms
Cervidil®
minprositin E2
minprostin E2
Propess®
prostaglandin E2
Database Links
CAS Registry No. 363-24-6
ChEBI CHEBI:116390
ChEMBL Ligand CHEMBL548
DrugBank Ligand DB00917
Human Metabolome Database HMDB01220
PharmGKB Drug PA449345
PubChem CID 5280360
Search Google for chemical match using the InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N
Search Google for chemicals with the same backbone XEYBRNLFEZDVAW
Search PubMed clinical trials dinoprostone
Search PubMed titles dinoprostone
Search PubMed titles/abstracts dinoprostone
Wikipedia Prostaglandin_E2
Comments
PGE2 is an endogenous prostaglandin. Synthetic PGE2 is known as dinoprostone. PGE2 activates prostanoid family GPCRs.