ABCB subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

MDR1, PGP1 (ABCB1) Show summary »« Hide summary

Target Id	768
Systematic nomenclature	ABCB1
Common abbreviation	MDR1, PGP1
Previous and unofficial names	P-glycoprotein 1, ABC20, CD243, CLCS, GP170, MDR1, PGY1, colchicin sensitivity, multidrug resistance protein 1, Abcb1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, ATP-binding cassette, subfamily B (MDR/TAP), member 1A, Mdr1a, multiple drug resistant 1a, Evi32, MDR3, mdr-3, Pgp, Pgy3, Pgy-3, P-gp
Genes	ABCB1 (Hs), Abcb1a (Mm), Abcb1a (Rn)
Ensembl ID	ENSG00000085563 (Hs), ENSMUSG00000040584 (Mm), ENSRNOG00000008012 (Rn)
UniProtKB AC	P08183 (Hs), P21447 (Mm)
Comment	Responsible for the cellular export of many therapeutic drugs. The mouse and rat have two Mdr1 genes (gene names; Mdr1a and Mdr1b) while the human has only the one gene, MDR1,

TAP1 (ABCB2) Show summary »« Hide summary

Target Id	769
Systematic nomenclature	ABCB2
Common abbreviation	TAP1
Previous and unofficial names	Antigen peptide transporter 1, APT1, peptide supply factor 1 (PSF-1), peptide transporter TAP1, RING4, ATP-binding cassette sub-family B member 2, Cim, Transporter 1 ABC (ATP binding cassette), Ham1, TAP, MTP1, peptide transporter involved in antigen processing 1
Genes	TAP1 (Hs), Tap1 (Mm), Tap1 (Rn)
Ensembl ID	ENSG00000168394 (Hs), ENSMUSG00000037321 (Mm), ENSRNOG00000000457 (Rn)
UniProtKB AC	Q03518 (Hs), P21958 (Mm), P36370 (Rn)
Comment	Endoplasmic reticulum peptide transporter, possibly requires heterodimerdimerization with TAP2.

TAP2 (ABCB3) Show summary »« Hide summary

Target Id	770
Systematic nomenclature	ABCB3
Common abbreviation	TAP2
Previous and unofficial names	Antigen peptide transporter 2 (APT2), peptide supply factor 2 (PSF-2), Peptide transporter TAP2, ATP-binding cassette sub-family B member 3, Cim, Transporter 2 ABC (ATP binding cassette), Ham2, MTP2, peptide transporter involved in antigen processing 2, RING11
Genes	TAP2 (Hs), Tap2 (Mm), Tap2 (Rn)
Ensembl ID	ENSG00000204267 (Hs), ENSMUSG00000024339 (Mm), ENSRNOG00000000455 (Rn)
UniProtKB AC	Q03519 (Hs), P36371 (Mm), P36372 (Rn)
Comment	Endoplasmic reticulum peptide transporter, possibly as requires heterodimerization with TAP1.

PGY3 (ABCB4) Show summary »« Hide summary

Target Id	771
Systematic nomenclature	ABCB4
Common abbreviation	PGY3
Previous and unofficial names	P-glycoprotein 3, GBD1, MDR2, MDR3, PFIC-3, PGY3, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2, multidrug resistance protein 2, multidrug resistance protein 3, P-glycoprotein 2, P-glycoprotein 3/ multidrug resistance 2, Pgy2
Genes	ABCB4 (Hs), Abcb4 (Mm), Abcb4 (Rn)
Ensembl ID	ENSG00000005471 (Hs), ENSMUSG00000042476 (Mm), ENSRNOG00000029207 (Rn)
UniProtKB AC	P21439 (Hs), P21440 (Mm), Q08201 (Rn)
Comment	Transports phosphatidylcholine from intracellular to extracellular face of the hepatocyte canalicular membrane [5]

ABCB5 Show summary »« Hide summary

Target Id	772
Systematic nomenclature	ABCB5
Previous and unofficial names	ABCB5alpha, ABCB5beta, ATP-binding cassette, sub-family B (MDR/TAP), member 5
Genes	ABCB5 (Hs), Abcb5 (Mm), Abcb5 (Rn)
Ensembl ID	ENSG00000004846 (Hs), ENSMUSG00000072791 (Mm), ENSRNOG00000006398 (Rn)
UniProtKB AC	Q2M3G0 (Hs)
Comment	Multidrug resistance protein in, and marker of, melanoma cells [7]

MTABC3 (ABCB6) Show summary »« Hide summary

Target Id	773
Systematic nomenclature	ABCB6
Common abbreviation	MTABC3
Previous and unofficial names	Mitochondrial ABC transporter 3, P-glycoprotein-related protein, ubiquitously expressed mammalian ABC half transporter, MTABC3, umat, ATP-binding cassette half-transporter, ATP-binding cassette sub-family B member 6, mitochondrial, ATP-binding cassette, sub-family B (MDR/TAP), member 6
Genes	ABCB6 (Hs), Abcb6 (Mm), Abcb6 (Rn)
Ensembl ID	ENSG00000115657 (Hs), ENSMUSG00000026198 (Mm), ENSRNOG00000018697 (Rn)
UniProtKB AC	Q9NP58 (Hs), Q9DC29 (Mm), O70595 (Rn)
Comment	Putative mitochondrial porphyrin transporter [4]; other subcellular localizations are possible, such as the plasma membrane, as a specific determinant of the Langereis blood group system [2].

ABC7 (ABCB7) Show summary »« Hide summary

Target Id	774
Systematic nomenclature	ABCB7
Common abbreviation	ABC7
Previous and unofficial names	ABC7, ASAT, ABC transporter 7 protein, ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ATP-binding cassette, sub-family B (MDR/TAP), member 7, Atm1p
Genes	ABCB7 (Hs), Abcb7 (Mm), Abcb7 (Rn)
Ensembl ID	ENSG00000131269 (Hs), ENSMUSG00000031333 (Mm), ENSRNOG00000002790 (Rn)
UniProtKB AC	O75027 (Hs), Q61102 (Mm), Q704E8 (Rn)
Comment	Mitochondrial; reportedly essential for haematopoiesis [6]

MABC1 (ABCB8) Show summary »« Hide summary

Target Id	775
Systematic nomenclature	ABCB8
Common abbreviation	MABC1
Previous and unofficial names	MABC1, mitochondrial ABC protein, ABC transporter 8, ATP-binding cassette sub-family B member 8, mitochondrial, ATP-binding cassette, sub-family B (MDR/TAP), member 8
Genes	ABCB8 (Hs), Abcb8 (Mm), Abcb8 (Rn)
Ensembl ID	ENSG00000197150 (Hs), ENSMUSG00000028973 (Mm), ENSRNOG00000008557 (Rn)
UniProtKB AC	Q9NUT2 (Hs), Q9CXJ4 (Mm), Q5RKI8 (Rn)
Comment	Mitochondrial; suggested to play a role in chemoresistance of melanoma [1]

TAPL (ABCB9) Show summary »« Hide summary

Target Id	776
Systematic nomenclature	ABCB9
Common abbreviation	TAPL
Previous and unofficial names	ABC transporter 9 protein, ATP-binding cassette, sub-family B (MDR/TAP), member 9, Tapl, TAP-like ABC transporter
Genes	ABCB9 (Hs), Abcb9 (Mm), Abcb9 (Rn)
Ensembl ID	ENSG00000150967 (Hs), ENSMUSG00000029408 (Mm), ENSRNOG00000001082 (Rn)
UniProtKB AC	Q9NP78 (Hs), Q9JJ59 (Mm), Q9QYJ4 (Rn)
Comment	Reported to be lysosomal [3]

MTABC2 (ABCB10) Show summary »« Hide summary

Target Id	777
Systematic nomenclature	ABCB10
Common abbreviation	MTABC2
Previous and unofficial names	Mitochondrial ABC transporter 2, M-ABC2, MTABC2, ABC transporter 10 protein, ATP-binding cassette, sub-family B (MDR/TAP), member 10, ABC-me, ATP-binding cassette sub-family B member 10, mitochondrial
Genes	ABCB10 (Hs), Abcb10 (Mm), Abcb10 (Rn)
Ensembl ID	ENSG00000135776 (Hs), ENSMUSG00000031974 (Mm), ENSRNOG00000017993 (Rn)
UniProtKB AC	Q9NRK6 (Hs), Q9JI39 (Mm)
Comment	Mitochondrial location; the first human ABC transporter to have a crystal structure reported [8].

ABC16 (ABCB11) Show summary »« Hide summary

Target Id	778
Systematic nomenclature	ABCB11
Common abbreviation	ABC16
Previous and unofficial names	Bile salt export pump, BSEP, PFIC2, PGY4, SPGP, ABC16, ABC member 16, MDR/TAP subfamily, progressive familial intrahepatic cholestasis 2, ATP-binding cassette, sub-family B (MDR/TAP), member 11, sister of P-glycoprotein, Lith1
Genes	ABCB11 (Hs), Abcb11 (Mm), Abcb11 (Rn)
Ensembl ID	ENSG00000073734 (Hs), ENSMUSG00000027048 (Mm), ENSRNOG00000050860 (Rn)
UniProtKB AC	O95342 (Hs), Q9QY30 (Mm), O70127 (Rn)
Comment	Loss-of-function mutations are associated with progressive familial intrahepatic cholestasis type 2 [9]

References

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1. Elliott AM, Al-Hajj MA. (2009) ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol. Cancer Res., 7 (1): 79-87. [PMID:19147539]

2. Helias V, Saison C, Ballif BA, Peyrard T, Takahashi J, Takahashi H, Tanaka M, Deybach JC, Puy H, Le Gall M et al.. (2012) ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis. Nat. Genet., 44 (2): 170-3. [PMID:22246506]

3. Kamakura A, Fujimoto Y, Motohashi Y, Ohashi K, Ohashi-Kobayashi A, Maeda M. (2008) Functional dissection of transmembrane domains of human TAP-like (ABCB9). Biochem. Biophys. Res. Commun., 377 (3): 847-51. [PMID:18952056]

4. Krishnamurthy PC, Du G, Fukuda Y, Sun D, Sampath J, Mercer KE, Wang J, Sosa-Pineda B, Murti KG, Schuetz JD. (2006) Identification of a mammalian mitochondrial porphyrin transporter. Nature, 443 (7111): 586-9. [PMID:17006453]

5. Oude Elferink RP, Paulusma CC. (2007) Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Pflugers Arch., 453 (5): 601-10. [PMID:16622704]

6. Pondarre C, Campagna DR, Antiochos B, Sikorski L, Mulhern H, Fleming MD. (2007) Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood, 109 (8): 3567-9. [PMID:17192398]

7. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C et al.. (2008) Identification of cells initiating human melanomas. Nature, 451 (7176): 345-9. [PMID:18202660]

8. Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J et al.. (2013) Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc. Natl. Acad. Sci. U.S.A., 110 (24): 9710-5. [PMID:23716676]

9. Stieger B. (2009) Recent insights into the function and regulation of the bile salt export pump (ABCB11). Curr. Opin. Lipidol., 20 (3): 176-81. [PMID:19684528]

How to cite this family page

Database page citation:

ABCB subfamily. Accessed on 25/01/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=152.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol. 170: 1706–1796.