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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
MDR1, PGP1 (ABCB1)
C
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TAP1 (ABCB2) C Show summary »« Hide summary
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TAP2 (ABCB3)
C
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PGY3 (ABCB4) C Show summary »« Hide summary
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ABCB5 C Show summary »« Hide summary
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MTABC3 (ABCB6) C Show summary »« Hide summary
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ABC7 (ABCB7) C Show summary »« Hide summary
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MABC1 (ABCB8) C Show summary »« Hide summary
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TAPL (ABCB9) C Show summary »« Hide summary
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MTABC2 (ABCB10) C Show summary »« Hide summary
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ABC16 (ABCB11) C Show summary »« Hide summary
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1. Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH et al.. (2013) ATP-binding cassette B10 regulates early steps of heme synthesis. Circ. Res., 113 (3): 279-87. [PMID:23720443]
2. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ. (2002) The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology, 123 (5): 1649-58. [PMID:12404239]
3. Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P. (2015) Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver. J. Biol. Chem., 290 (12): 7871-86. [PMID:25623066]
4. Demirel Ö, Jan I, Wolters D, Blanz J, Saftig P, Tampé R, Abele R. (2012) The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J. Cell. Sci., 125 (Pt 18): 4230-40. [PMID:22641697]
5. Elliott AM, Al-Hajj MA. (2009) ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol. Cancer Res., 7 (1): 79-87. [PMID:19147539]
6. Garzel B, Yang H, Zhang L, Huang SM, Polli JE, Wang H. (2014) The role of bile salt export pump gene repression in drug-induced cholestatic liver toxicity. Drug Metab. Dispos., 42 (3): 318-22. [PMID:24335466]
7. Helias V, Saison C, Ballif BA, Peyrard T, Takahashi J, Takahashi H, Tanaka M, Deybach JC, Puy H, Le Gall M et al.. (2012) ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis. Nat. Genet., 44 (2): 170-3. [PMID:22246506]
8. Hirschfield GM, Chapman RW, Karlsen TH, Lammert F, Lazaridis KN, Mason AL. (2013) The genetics of complex cholestatic disorders. Gastroenterology, 144 (7): 1357-74. [PMID:23583734]
9. Ichikawa Y, Bayeva M, Ghanefar M, Potini V, Sun L, Mutharasan RK, Wu R, Khechaduri A, Jairaj Naik T, Ardehali H. (2012) Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc. Natl. Acad. Sci. U.S.A., 109 (11): 4152-7. [PMID:22375032]
10. Krishnamurthy PC, Du G, Fukuda Y, Sun D, Sampath J, Mercer KE, Wang J, Sosa-Pineda B, Murti KG, Schuetz JD. (2006) Identification of a mammalian mitochondrial porphyrin transporter. Nature, 443 (7111): 586-9. [PMID:17006453]
11. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL et al.. (2014) ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature, 511 (7509): 353-7. [PMID:25030174]
12. Morgan RE, Trauner M, van Staden CJ, Lee PH, Ramachandran B, Eschenberg M, Afshari CA, Qualls Jr CW, Lightfoot-Dunn R, Hamadeh HK. (2010) Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol. Sci., 118 (2): 485-500. [PMID:20829430]
13. Oude Elferink RP, Paulusma CC. (2007) Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Pflugers Arch., 453 (5): 601-10. [PMID:16622704]
14. Pondarre C, Campagna DR, Antiochos B, Sikorski L, Mulhern H, Fleming MD. (2007) Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood, 109 (8): 3567-9. [PMID:17192398]
15. Pondarré C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, Deck KM, McDonald A, Han AP, Medlock A, Kutok JL et al.. (2006) The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum. Mol. Genet., 15 (6): 953-64. [PMID:16467350]
16. Seyffer F, Tampé R. (2015) ABC transporters in adaptive immunity. Biochim. Biophys. Acta, 1850 (3): 449-60. [PMID:24923865]
17. Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J et al.. (2013) Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc. Natl. Acad. Sci. U.S.A., 110 (24): 9710-5. [PMID:23716676]
18. Stieger B. (2009) Recent insights into the function and regulation of the bile salt export pump (ABCB11). Curr. Opin. Lipidol., 20 (3): 176-81. [PMID:19684528]
19. Tang L, Bergevoet SM, Bakker-Verweij G, Harteveld CL, Giordano PC, Nijtmans L, de Witte T, Jansen JH, Raymakers RA, van der Reijden BA. (2012) Human mitochondrial ATP-binding cassette transporter ABCB10 is required for efficient red blood cell development. Br. J. Haematol., 157 (1): 151-4. [PMID:22085049]
20. Wilson BJ, Saab KR, Ma J, Schatton T, Pütz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY et al.. (2014) ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res., 74 (15): 4196-207. [PMID:24934811]
Database page citation:
Mary Vore. ABCB subfamily. Accessed on 23/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=152.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.