ATP-binding cassette transporter family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ATP-binding cassette transporters are ubiquitous membrane proteins characterized by active ATP-dependent movement of a range of substrates, including ions, lipids, peptides, steroids. Individual subunits are typically made up of two groups of 6TM-spanning domains, with two nucleotide-binding domains (NBD). The majority of eukaryotic ABC transporters are ‘full’ transporters incorporating both TM and NBD entities. Some ABCs, notably the ABCD and ABCG families are half-transporters with only a single membrane spanning domain and one NBD, and are only functional as homo- or heterodimers. Eukaryotic ABC transporters convey substrates from the cytoplasm, either out of the cell or into intracellular organelles. Their role in the efflux of exogenous compounds, notably chemotherapeutic agents, has led to considerable interest.

ABCA subfamily

Transporters

ABC1, CERP (ABCA1) Show summary »

ABC2 (ABCA2) Show summary »

ABC3, ABCC (ABCA3) Show summary »

ABCR (ABCA4) Show summary »

ABCA5 Show summary »

ABCA6 Show summary »

ABCA7 Show summary »

ABCA8 Show summary »

ABCA9 Show summary »

ABCA10 Show summary »

ABCA12 Show summary » More detailed page

ABCA13 Show summary »

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ABCB subfamily

Transporters

MDR1, PGP1 (ABCB1) Show summary »

TAP1 (ABCB2) Show summary »

TAP2 (ABCB3) Show summary »

PGY3 (ABCB4) Show summary »

ABCB5 Show summary »

MTABC3 (ABCB6) Show summary »

ABC7 (ABCB7) Show summary »

MABC1 (ABCB8) Show summary »

TAPL (ABCB9) Show summary »

MTABC2 (ABCB10) Show summary »

ABC16 (ABCB11) Show summary »

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ABCC subfamily

Transporters

MRP1 (ABCC1) Show summary » More detailed page

MRP2, cMOAT (ABCC2) Show summary »

MRP3 (ABCC3) Show summary »

MRP4 (ABCC4) Show summary »

MRP5 (ABCC5) Show summary »

MRP6 (ABCC6) Show summary »

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Show summary » More detailed page

MRP7 (ABCC10) Show summary »

MRP8 (ABCC11) Show summary »

MRP9 (ABCC12) Show summary »

ABCC9 Show summary » More detailed page

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ABCD subfamily of peroxisomal ABC transporters

Overview

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This family of ‘half-transporters’ act as homo- or heterodimers to accumulate fatty acid-CoA esters into peroxisomes for oxidative metabolism [9].

Transporters

ALDP (ABCD1) Show summary »

ALDR (ABCD2) Show summary »

PMP70 (ABCD3) Show summary »

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ABCG subfamily

Overview

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This family of ‘half-transporters’ act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. They are associated with cellular export of sterols and phospholipids, as well as exogenous drugs (ABCG2).

Transporters

ABC8 (ABCG1) Show summary »

ABCP (ABCG2) Show summary »

ABCG4 Show summary »

ABCG5 Show summary »

ABCG8 Show summary »

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Further reading

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References

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