ATP-binding cassette family
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ATP-binding cassette transporters are ubiquitous membrane proteins characterized by facilitated movement of a range of substrates, including ions, lipids, peptides, steroids. The functional transporter is probably dimeric, with individual subunits typically made up of two groups of 6TM-spanning domains, with two nucleotide-binding domains (NBD). The majority of eukaryotic ABC transporters are ‘full’ transporters incorporating both TM and NBD entities. Some ABCs, notably the ABCD and ABCG families, appear relatively truncated and are only functional as homo- or heterodimers. Eukaryotic ABC transporters convey substrates from the cytoplasm, either out of the cell or into intracellular organelles. Their role in the efflux of exogenous compounds, notably chemotherapeutic agents, has led to considerable interest.
ABCA subfamily
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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ABCA1
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| Systematic nomenclature |
ABCA1 |
| Common abbreviation |
ABC1, CERP |
| Other names |
Cholesterol efflux regulatory protein,
ABC1,
HDLDT1,
TGD,
Tangier disease,
ATP-binding cassette sub-family A member 1,
ATP-binding cassette, sub-family A (ABC1), member 1
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| Genes |
ABCA1 (Hs), Abca1 (Mm), Abca1 (Rn) |
| Ensembl ID |
ENSG00000165029 (Hs), ENSMUSG00000015243 (Mm), ENSRNOG00000018126 (Rn)
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| Comment |
Loss-of-function mutations are associated with Tangier disease, in with plasma HDL cholesterol levels are greatly reduced
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ABCA2
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| Systematic nomenclature |
ABCA2 |
| Common abbreviation |
ABC2 |
| Other names |
ABC2,
ATP-binding cassette 2,
ATP-binding cassette sub-family A member 2,
ATP-binding cassette transporter 2,
ATP-binding cassette, sub-family A (ABC1), member 2,
D2H0S1474E
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| Genes |
ABCA2 (Hs), Abca2 (Mm), Abca2 (Rn) |
| Ensembl ID |
ENSG00000107331 (Hs), ENSMUSG00000026944 (Mm), ENSRNOG00000014268 (Rn)
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ABCA3
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| Systematic nomenclature |
ABCA3 |
| Common abbreviation |
ABC3, ABCC |
| Other names |
ABC3,
ABC-C,
EST111653,
LBM180,
Abca3_predicted,
LOC302973,
ATP-binding cassette sub-family A member 3,
ATP-binding cassette, sub-family A (ABC1), member 3,
ATP-binding cassette, sub-family A (ABC1), member 3 (predicted)
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| Genes |
ABCA3 (Hs), Abca3 (Mm), Abca3 (Rn) |
| Ensembl ID |
ENSG00000167972 (Hs), ENSMUSG00000024130 (Mm), ENSRNOG00000008322 (Rn)
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| Comment |
Loss-of-function mutations are associated with pulmonary surfactant deficiency
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ABCA4
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| Systematic nomenclature |
ABCA4 |
| Common abbreviation |
ABCR |
| Other names |
Retinal-specific ATP-binding cassette transporter,
RIM ABC transporter,
RmP,
Stargardt disease protein,
STGD1,
ABCR,
RP19,
STGD,
FFM,
ARMD2,
ATP-binding cassette transporter, retinal-specific,
Stargardt disease,
Abca4_predicted,
LOC310836,
ATP-binding cassette, sub-family A (ABC1), member 4,
ATP-binding cassette, sub-family A (ABC1), member 4 (predicted),
Rim protein,
Abc10
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| Genes |
ABCA4 (Hs), Abca4 (Mm), Abca4 (Rn) |
| Ensembl ID |
ENSG00000198691 (Hs), ENSMUSG00000028125 (Mm), ENSRNOG00000012892 (Rn)
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| Comment |
Retinal-specific transporter of N-retinylPE; loss-of-function mutations are associated with Stargardt disease, a juvenile onset macular degenerative disease
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ABCA5
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ABCA6
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| Systematic nomenclature |
ABCA6 |
| Other names |
EST155051,
Abca6_predicted,
LOC303639,
ATP-binding cassette sub-family A member 6,
ATP-binding cassette, sub-family A (ABC1), member 6,
ATP-binding cassette, sub-family A (ABC1), member 6 (predicted),
ATP-binding cassette, subfamily A (ABC1), member 6
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| Genes |
ABCA6 (Hs), Abca6 (Mm), Abca6 (Rn) |
| Ensembl ID |
ENSG00000154262 (Hs), ENSMUSG00000044749 (Mm)
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ABCA7
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| Systematic nomenclature |
ABCA7 |
| Other names |
ABCX,
ATP-binding cassette sub-family A member 7,
ATP-binding cassette, sub-family A (ABC1), member 7,
ATP-binding cassette, sub-family A, member 7,
Abc51
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| Genes |
ABCA7 (Hs), Abca7 (Mm), Abca7 (Rn) |
| Ensembl ID |
ENSG00000064687 (Hs), ENSMUSG00000035722 (Mm), ENSRNOG00000012939 (Rn)
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| Comment |
Genome wide association studies identify ABCA7 variants as associated with Alzheimer’s Disease [5]
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ABCA8
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| Systematic nomenclature |
ABCA8 |
| Other names |
KIAA0822,
Abca8b,
Abca8b_predicted,
LOC303637,
ATP-binding cassette, sub-family A (ABC1), member 8,
ATP-binding cassette, sub-family A (ABC1), member 8b,
ATP-binding cassette, sub-family A (ABC1), member 8b ,
ATP-binding cassette, sub-family A (ABC1), member 8b (predicted),
ATP-binding cassette, subfamily A (ABC1), member 8,
Abca8
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| Genes |
ABCA8 (Hs), Abca8b (Mm), Abca8 (Rn) |
| Ensembl ID |
ENSG00000141338 (Hs), ENSMUSG00000020620 (Mm), ENSRNOG00000004040 (Rn)
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ABCA9
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| Systematic nomenclature |
ABCA9 |
| Other names |
EST640918,
Abca9_predicted,
LOC287788,
ATP-binding cassette sub-family A member 9,
ATP-binding cassette transporter sub-family A member 9,
ATP-binding cassette transporter sub-family A member 9 (predicted),
ATP-binding cassette, sub-family A (ABC1), member 9,
ATP-binding cassette, subfamily A (ABC1), member 9
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| Genes |
ABCA9 (Hs), Abca9 (Mm), Abca9 (Rn) |
| Ensembl ID |
ENSG00000154258 (Hs), ENSMUSG00000041797 (Mm), ENSRNOG00000004295 (Rn)
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ABCA10
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ABCA12
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| Systematic nomenclature |
ABCA12 |
| Other names |
ICR2B,
DKFZP434G232,
LI2,
ichthyosis congenita II, lamellar ichthyosis B,
Abca12_predicted,
LOC301482,
ATP-binding cassette sub-family A member 12,
ATP-binding cassette, sub-family A (ABC1), member 12,
ATP-binding cassette, sub-family A (ABC1), member 12 (predicted),
ATP-binding cassette, subfamily A (ABC1), member 12
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| Genes |
ABCA12 (Hs), Abca12 (Mm), Abca12 (Rn) |
| Ensembl ID |
ENSG00000144452 (Hs), ENSMUSG00000050296 (Mm), ENSRNOG00000015248 (Rn)
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| Comment |
Reported to play a role in skin ceramide formation [19]
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ABCA13
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| Systematic nomenclature |
ABCA13 |
| Other names |
FLJ33876,
FLJ33951,
Abca13_predicted,
LOC289797,
ATP-binding cassette, sub-family A (ABC1), member 13,
ATP-binding cassette, sub-family A (ABC1), member 13 (predicted)
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| Genes |
ABCA13 (Hs), Abca13 (Mm), Abca13 (Rn) |
| Ensembl ID |
ENSG00000179869 (Hs), ENSMUSG00000004668 (Mm), ENSRNOG00000025645 (Rn)
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Comments
ABCB subfamily
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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ABCB1
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| Systematic nomenclature |
ABCB1 |
| Common abbreviation |
MDR1, PGP1 |
| Other names |
Multi-drug resistance protein 1,
P-glycoprotein 1,
CD243 antigen,
PGY1,
MDR1,
CLCS,
P-gp,
CD243,
GP170,
ABC20,
colchicin sensitivity,
multidrug resistance protein 1,
Abcb1,
Mdr1a,
ATP-binding cassette, sub-family B (MDR/TAP), member 1,
ATP-binding cassette, sub-family B (MDR/TAP), member 1A,
ATP-binding cassette, subfamily B (MDR/TAP), member 1A,
multiple drug resistant 1a,
mdr-3,
P-glycoprotein,
Pgy-3,
Pgy3,
Pgp,
MDR3,
Evi32
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| Genes |
ABCB1 (Hs), Abcb1a (Mm), Abcb1a (Rn) |
| Ensembl ID |
ENSG00000085563 (Hs), ENSMUSG00000040584 (Mm), ENSRNOG00000008012 (Rn)
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| Comment |
Responsible for the cellular export of many therapeutic drugs
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ABCB2
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| Systematic nomenclature |
ABCB2 |
| Common abbreviation |
TAP1 |
| Other names |
Antigen peptide transporter 1,
APT1,
peptide transporter TAP1,
peptide supply factor 1 (PSF-1),
peptide transporter involved in antigen processing 1,
PSF1,
RING4,
D6S114E,
Cim,
MGC124549,
ATP-binding cassette sub-family B member 2,
Transporter 1 ABC (ATP binding cassette),
Transporter 1, ABC (ATP binding cassette),
PSF-1,
MTP1,
Ham-1,
Tap-1,
Ham1,
TAP
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| Genes |
TAP1 (Hs), Tap1 (Mm), Tap1 (Rn) |
| Ensembl ID |
ENSG00000168394 (Hs), ENSMUSG00000037321 (Mm), ENSRNOG00000000457 (Rn)
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| Comment |
Endoplasmic reticulum, possibly as heterodimer with TAP2
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ABCB3
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| Systematic nomenclature |
ABCB3 |
| Common abbreviation |
TAP2 |
| Other names |
Antigen peptide transporter 2 (APT2),
Peptide transporter TAP2,
peptide supply factor 2 (PSF-2),
peptide transporter involved in antigen processing 2,
PSF2,
RING11,
D6S217E,
Cim,
MGC108646,
APT2,
ATP-binding cassette sub-family B member 3,
Transporter 2 ABC (ATP binding cassette),
Transporter 2, ABC (ATP binding cassette),
antigen peptide transporter 2,
MTP2,
Ham-2,
Ham2,
Tap-2
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| Genes |
TAP2 (Hs), Tap2 (Mm), Tap2 (Rn) |
| Ensembl ID |
ENSG00000204267 (Hs), ENSMUSG00000024339 (Mm), ENSRNOG00000000455 (Rn)
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| Comment |
Endoplasmic reticulum, possibly as heterodimer with TAP1
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ABCB4
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| Systematic nomenclature |
ABCB4 |
| Common abbreviation |
PGY3 |
| Other names |
Multi-drug resistance protein 3,
P-glycoprotein 3,
PGY3,
MDR3,
MDR2,
PFIC-3,
GBD1,
ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2,
ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2),
ATP-binding cassette sub-family B member 4,
ATP-binding cassette, sub-family B (MDR/TAP), member 4,
ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2),
ATP-binding cassette, subfamily B, member 4,
P-glycoprotein 2,
P-glycoprotein 3/ multidrug resistance 2,
multidrug resistance protein 2,
multidrug resistance protein 3,
mdr-2,
Pgy-2,
Pgy2
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| Genes |
ABCB4 (Hs), Abcb4 (Mm), Abcb4 (Rn) |
| Ensembl ID |
ENSG00000005471 (Hs), ENSMUSG00000042476 (Mm), ENSRNOG00000029207 (Rn)
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| Comment |
Transports phosphatidylcholine from intracellular to extracellular face of the hepatocyte canalicular membrane [11]
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ABCB5
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| Systematic nomenclature |
ABCB5 |
| Other names |
EST422562,
ABCB5beta,
ABCB5alpha,
P-glycoprotein ABCB5,
ATP-binding cassette protein,
LOC314537,
RGD1566342,
RGD1566342_predicted,
ATP-binding cassette, sub-family B (MDR/TAP), member 5,
ATP-binding cassette, subfamily B (MDR/TAP), member 5,
similar to ATP-binding cassette, sub-family B, member 5,
similar to ATP-binding cassette, sub-family B, member 5 (predicted)
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| Genes |
ABCB5 (Hs), Abcb5 (Mm), Abcb5 (Rn) |
| Ensembl ID |
ENSG00000004846 (Hs), ENSMUSG00000072791 (Mm), ENSRNOG00000006398 (Rn)
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| Comment |
Multidrug resistance protein in, and marker of, melanoma cells [15]
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ABCB6
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| Systematic nomenclature |
ABCB6 |
| Common abbreviation |
MTABC3 |
| Other names |
Mitochondrial ABC transporter 3,
ubiquitously expressed mammalian ABC half transporter,
P-glycoprotein-related protein,
EST45597,
umat,
MTABC3,
ATP-binding cassette half-transporter,
MGC93242,
ATP-binding cassette sub-family B member 6, mitochondrial,
ATP-binding cassette, sub-family B (MDR/TAP), member 6,
ubiquitously-expressed mammalian ABC half transporter
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| Genes |
ABCB6 (Hs), Abcb6 (Mm), Abcb6 (Rn) |
| Ensembl ID |
ENSG00000115657 (Hs), ENSMUSG00000026198 (Mm), ENSRNOG00000018697 (Rn)
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| Comment |
Mitochondrial porphyrin transporter [10]
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ABCB7
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| Systematic nomenclature |
ABCB7 |
| Common abbreviation |
ABC7 |
| Other names |
ABC7,
EST140535,
Atm1p,
ASAT,
ABC transporter 7 protein,
ATP-binding cassette sub-family B member 7, mitochondrial,
ATP-binding cassette transporter 7,
ATP-binding cassette, sub-family B (MDR/TAP), member 7,
ATP-binding cassette, sub-family B, member 7, mitochondrial,
ATP-binding cassette, sub-family B, member 7, mitochondrial precursor
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| Genes |
ABCB7 (Hs), Abcb7 (Mm), Abcb7 (Rn) |
| Ensembl ID |
ENSG00000131269 (Hs), ENSMUSG00000031333 (Mm)
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| Comment |
Mitochondrial; reportedly essential for haematopoiesis [13]
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ABCB8
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| Systematic nomenclature |
ABCB8 |
| Common abbreviation |
MABC1 |
| Other names |
EST328128,
M-ABC1,
MABC1,
mitochondrial ABC protein,
Abcb8_predicted,
LOC362302,
MGC93731,
ABC transporter 8,
ATP-binding cassette sub-family B member 8, mitochondrial,
ATP-binding cassette, sub-family B (MDR/TAP), member 8,
ATP-binding cassette, sub-family B (MDR/TAP), member 8 (predicted),
ATP-binding cassette, sub-family B, member 8
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| Genes |
ABCB8 (Hs), Abcb8 (Mm), Abcb8 (Rn) |
| Ensembl ID |
ENSG00000197150 (Hs), ENSMUSG00000028973 (Mm), ENSRNOG00000008557 (Rn)
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| Comment |
Mitochondrial; suggested to play a role in chemoresistance of melanoma [4]
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ABCB9
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| Systematic nomenclature |
ABCB9 |
| Common abbreviation |
TAPL |
| Other names |
TAP-like protein,
hABCB9,
EST122234,
Tapl,
ABC transporter 9 protein,
ATP-binding cassette sub-family B member 9,
ATP-binding cassette transporter 9,
ATP-binding cassette, sub-family B (MDR/TAP), member 9,
TAP-like ABC transporter
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| Genes |
ABCB9 (Hs), Abcb9 (Mm), Abcb9 (Rn) |
| Ensembl ID |
ENSG00000150967 (Hs), ENSMUSG00000029408 (Mm), ENSRNOG00000001082 (Rn)
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| Comment |
Reported to be lysosomal [6]
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ABCB10
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| Systematic nomenclature |
ABCB10 |
| Common abbreviation |
MTABC2 |
| Other names |
Mitochondrial ABC transporter 2,
EST20237,
M-ABC2,
MTABC2,
ATP-binding cassette sub-family B member 10, mitochondrial,
ATP-binding cassette transporter 10,
ABC transporter 10 protein,
mitochondrial ATP-binding cassette 2,
Abcb10_predicted,
LOC361439,
MGC109142,
ATP-binding cassette, sub-family B (MDR/TAP), member 10,
ATP-binding cassette, sub-family B (MDR/TAP), member 10 (predicted),
ABC-me
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| Genes |
ABCB10 (Hs), Abcb10 (Mm), Abcb10 (Rn) |
| Ensembl ID |
ENSG00000135776 (Hs), ENSMUSG00000031974 (Mm), ENSRNOG00000017993 (Rn)
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| Comment |
Mitochondrial
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ABCB11
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| Systematic nomenclature |
ABCB11 |
| Common abbreviation |
ABC16 |
| Other names |
Bile salt export pump,
BSEP,
PFIC-2,
PFIC2,
PGY4,
SPGP,
ABC16,
progressive familial intrahepatic cholestasis 2,
ABC member 16, MDR/TAP subfamily,
ATP-binding cassette sub-family B member 11,
ATP-binding cassette, sub-family B (MDR/TAP), member 11,
sister of P-glycoprotein,
Lith1
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| Genes |
ABCB11 (Hs), Abcb11 (Mm), Abcb11 (Rn) |
| Ensembl ID |
ENSG00000073734 (Hs), ENSMUSG00000027048 (Mm)
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| Comment |
Loss-of-function mutations are associated with familial intrahepatic cholestasis [16]
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ABCC subfamily
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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ABCC1
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| Systematic nomenclature |
ABCC1 |
| Common abbreviation |
MRP1 |
| Other names |
Multidrug resistance-associated protein 1,
leukotriene C4 transporter,
MRP,
MRP1,
GS-X,
multidrug resistance associated protein 1,
Abcc1a,
Avcc1a,
ATP-binding cassette sub-family C (CFTR/MRP) member 1 (multiple drug resistance-associated protein),
ATP-binding cassette sub-family C member 1,
ATP-binding cassette, sub-family C (CFTR/MRP), member 1,
ATP-binding cassette, sub-family C, member 1-like,
LTC4 transporter,
Multidrug resistance protein 1,
leukotriene C(4) transporter,
multidrug resistance protein,
multidrug resistance-associated protein 1-like,
multiple drug resistance-associated protein,
ATP-binding cassette, sub-family C (CFTR/MRP), member 1a,
Mdrap,
Abcc1b,
ATP-binding cassette sub-family C (CFTR/MRP) member 1a
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| Genes |
ABCC1 (Hs), Abcc1 (Mm), Abcc1 (Rn) |
| Ensembl ID |
ENSG00000103222 (Hs), ENSMUSG00000023088 (Mm), ENSRNOG00000032748 (Rn)
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| Comment |
Exhibits a broad substrate specificity [1]
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ABCC2
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| Systematic nomenclature |
ABCC2 |
| Common abbreviation |
MRP2, cMOAT |
| Other names |
Multidrug resistance-associated protein 2,
canalicular multispecific organic anion transporter 1,
Canalicular multidrug resistance protein,
CMOAT,
DJS,
MRP2,
cMRP,
ATP-binding cassette sub-family C member 2,
ATP-binding cassette, sub-family C (CFTR/MRP) member 2,
ATP-binding cassette, sub-family C (CFTR/MRP), member 2,
calicular multispecific organic anion transporter,
canalicular multispecific organic anion transporter,
multidrug resistance associated protein 2,
multidrug resistance protein 2
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| Genes |
ABCC2 (Hs), Abcc2 (Mm), Abcc2 (Rn) |
| Ensembl ID |
ENSG00000023839 (Hs), ENSMUSG00000025194 (Mm)
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| Comment |
Loss-of-function mutations are associated with Dubin-Johnson syndrome, in which plasma levels of conjugated bilirubin are elevated
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ABCC3
Show »« Hide
| Systematic nomenclature |
ABCC3 |
| Common abbreviation |
MRP3 |
| Other names |
Multidrug resistance-associated protein 3,
canalicular multispecific organic anion transporter 2,
multi-specific organic anion transporter-D,
MOAT-D,
MRP3,
cMOAT2,
EST90757,
MLP2,
ATP-binding cassette sub-family C member 3,
ATP-binding cassette, sub-family C (CFTR/MRP), member 3,
MLP-2,
MRP-like protein 2,
multidrug resistance protein 3,
organic anion transporter
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| Genes |
ABCC3 (Hs), Abcc3 (Mm), Abcc3 (Rn) |
| Ensembl ID |
ENSG00000108846 (Hs), ENSMUSG00000020865 (Mm), ENSRNOG00000002948 (Rn)
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| Comment |
Transports conjugates of glutathione, sulfate or glucuronide [2]
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ABCC4
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| Systematic nomenclature |
ABCC4 |
| Common abbreviation |
MRP4 |
| Other names |
Multidrug resistance-associated protein 4,
multi-specific organic anion transporter-B,
MOAT-B,
MRP4,
EST170205,
MOATB,
canalicular multispecific organic anion transporter (ABC superfamily),
bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4),
multispecific organic anion transporter B,
ABC-tranporter,
ATP-binding cassette protein C4,
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
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| Genes |
ABCC4 (Hs), Abcc4 (Mm), Abcc4 (Rn) |
| Ensembl ID |
ENSG00000125257 (Hs), ENSMUSG00000032849 (Mm), ENSRNOG00000010064 (Rn)
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| Comment |
Although reported to facilitate cellular cyclic nucleotide export, this role has been questioned [2]; reported to export prostaglandins in a manner sensitive to NSAIDS [14]
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ABCC5
Show »« Hide
| Systematic nomenclature |
ABCC5 |
| Common abbreviation |
MRP5 |
| Other names |
Multidrug resistance-associated protein 5,
multi-specific organic anion transporter-C,
MOAT-C,
pABC11,
SMRP,
MRP5,
EST277145,
Abcc5a,
MGC156604,
ATP-binding cassette sub-family C (CFTR/MRP) member 5,
ATP-binding cassette sub-family C (CFTR/MRP) member 5a,
ATP-binding cassette sub-family C member 5,
ATP-binding cassette, sub-family C (CFTR/MRP), member 5,
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a,
Abcc5b
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| Genes |
ABCC5 (Hs), Abcc5 (Mm), Abcc5 (Rn) |
| Ensembl ID |
ENSG00000114770 (Hs), ENSMUSG00000022822 (Mm), ENSRNOG00000029178 (Rn)
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| Comment |
Although reported to facilitate cellular cyclic nucleotide export, this role has been questioned [2]
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ABCC6
Show »« Hide
| Systematic nomenclature |
ABCC6 |
| Common abbreviation |
MRP6 |
| Other names |
Multidrug resistance-associated protein 6,
anthracycline resistance-associated protein,
multi-specific organic anion transporter-E,
MOAT-E,
ARA,
PXE,
MRP6,
EST349056,
MLP1,
URG7,
pseudoxanthoma elasticum,
ATP-binding cassette sub-family C member 6,
ATP-binding cassette, sub-family C (CFTR/MRP), member 6,
MLP-1,
MRP-like protein 1,
liver multidrug resistance-associated protein 6,
DCC,
Dyscalc1
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| Genes |
ABCC6 (Hs), Abcc6 (Mm), Abcc6 (Rn) |
| Ensembl ID |
ENSG00000091262 (Hs), ENSMUSG00000030834 (Mm), ENSRNOG00000028781 (Rn)
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ABCC10
Show »« Hide
| Systematic nomenclature |
ABCC10 |
| Common abbreviation |
MRP7 |
| Other names |
Multidrug resistance-associated protein 7,
EST182763,
MRP7,
SIMRP7,
Abcc10_predicted,
LOC316231,
ATP-binding cassette, sub-family C (CFTR/MRP), member 10,
ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (predicted)
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| Genes |
ABCC10 (Hs), Abcc10 (Mm), Abcc10 (Rn) |
| Ensembl ID |
ENSG00000124574 (Hs), ENSMUSG00000032842 (Mm), ENSRNOG00000018863 (Rn)
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ABCC11
Show »« Hide
| Systematic nomenclature |
ABCC11 |
| Common abbreviation |
MRP8 |
| Other names |
Multidrug resistance-associated protein 8,
MRP8
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| Genes |
ABCC11 (Hs) |
| Ensembl ID |
ENSG00000121270 (Hs)
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| Comment |
Single nucleotide polymorphisms distinguish wet vs. dry earwax; association between earwax allele and breast cancer risk in Japanese but not European populations
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ABCC12
Show »« Hide
| Systematic nomenclature |
ABCC12 |
| Common abbreviation |
MRP9 |
| Other names |
Multidrug resistance-associated protein 9,
MRP9,
ATP-binding cassette protein C12,
ATP-binding cassette protein C12 variant A,
ATP-binding cassette sub-family C member 12,
ATP-binding cassette transporter sub-family C member 12,
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
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| Genes |
ABCC12 (Hs), Abcc12 (Mm), Abcc12 (Rn) |
| Ensembl ID |
ENSG00000140798 (Hs), ENSMUSG00000036872 (Mm), ENSRNOG00000015666 (Rn)
|
|
Comments
ABCD subfamily of peroxisomal ABC transporters
Overview Show »« Hide
This family of ‘half-transporters’ act as homo- or heterodimers to accumulate fatty acid-CoA esters into peroxisomes for oxidative metabolism [8].
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
|
ABCD1
Show »« Hide
| Systematic nomenclature |
ABCD1 |
| Common abbreviation |
ALDP |
| Other names |
Adrenoleukodystrophy protein,
ALD,
AMN,
ALDP,
adrenoleukodystrophy,
Abcd1_predicted,
LOC363516,
RGD1562128,
RGD1562128_predicted,
ATP-binding cassette sub-family D member 1,
ATP-binding cassette, sub-family D (ALD), member 1,
ATP-binding cassette, sub-family D (ALD), member 1 (predicted),
similar to mALDP,
similar to mALDP (predicted),
Aldgh
|
| Genes |
ABCD1 (Hs), Abcd1 (Mm), Abcd1 (Rn) |
| Ensembl ID |
ENSG00000101986 (Hs), ENSMUSG00000031378 (Mm), ENSRNOG00000018857 (Rn)
|
| Comment |
Coenzyme A esters of very long chain fatty acids [17-18]
|
|
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ABCD2
Show »« Hide
| Systematic nomenclature |
ABCD2 |
| Common abbreviation |
ALDR |
| Other names |
Adrenoleukodystrophy- related protein,
adrenoleukodystrophy-like 1,
ALDL1,
ALDR,
ALDRP,
ATP-binding cassette sub-family D member 2,
ATP-binding cassette, sub-family D (ALD), member 2,
adrenoleukodystrophy-related protein,
ABC39,
adrenoleukodystrophy related
|
| Genes |
ABCD2 (Hs), Abcd2 (Mm), Abcd2 (Rn) |
| Ensembl ID |
ENSG00000173208 (Hs), ENSMUSG00000055782 (Mm), ENSRNOG00000015538 (Rn)
|
| Comment |
Coenzyme A esters of very long chain unsaturated fatty acids [18]
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|
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ABCD3
Show »« Hide
| Systematic nomenclature |
ABCD3 |
| Common abbreviation |
PMP70 |
| Other names |
70 kDa peroxisomal membrane protein,
PXMP1,
PMP70,
ZWS2,
PMP70, 70-kDa peroxisomal membrane protein,
70-kDa peroxisomal membrane protein,
ATP-binding cassette sub-family D member 3,
ATP-binding cassette, sub-family D (ALD), member 3,
Peroxisomal membrane protein 1
|
| Genes |
ABCD3 (Hs), Abcd3 (Mm), Abcd3 (Rn) |
| Ensembl ID |
ENSG00000117528 (Hs), ENSMUSG00000028127 (Mm), ENSRNOG00000011929 (Rn)
|
|
Comments
ABCG subfamily
Overview Show »« Hide
This family of ‘half-transporters’ act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. They are associated with cellular export of sterols and phospholipids, as well as exogenous drugs (ABCG2).
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
|
ABCG1
Show »« Hide
| Systematic nomenclature |
ABCG1 |
| Common abbreviation |
ABC8 |
| Other names |
White protein homolog,
ABC8,
ATP-binding cassette transporter 8,
ATP-binding cassette sub-family G member 1,
ATP-binding cassette, sub-family G (WHITE), member 1,
White
|
| Genes |
ABCG1 (Hs), Abcg1 (Mm), Abcg1 (Rn) |
| Ensembl ID |
ENSG00000160179 (Hs), ENSMUSG00000024030 (Mm), ENSRNOG00000001158 (Rn)
|
| Comment |
Transports sterols and choline phospholipids [9]
|
|
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ABCG2
Show »« Hide
| Systematic nomenclature |
ABCG2 |
| Common abbreviation |
ABCP |
| Other names |
Placenta-specific ATP- binding cassette transporter,
breast cancer resistance protein,
BCRP,
mitoxantrone resistance-associated protein,
MXR,
CD338 antigen,
CDw338,
EST157481,
ABCP,
CD338,
BCRP1,
ATP-binding cassette protein G2,
ATP-binding cassette sub-family G member 2,
ATP-binding cassette, sub-family G (WHITE), member 2,
breast cancer resistance protein 1 homolog
|
| Genes |
ABCG2 (Hs), Abcg2 (Mm), Abcg2 (Rn) |
| Ensembl ID |
ENSG00000118777 (Hs), ENSMUSG00000029802 (Mm), ENSRNOG00000007041 (Rn)
|
| Comment |
Exhibits a broad substrate specificity, including urate and haem, as well as multiple synthetic compounds [9]
|
|
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ABCG4
Show »« Hide
| Systematic nomenclature |
ABCG4 |
| Other names |
White2,
putative ABC transporter,
ATP-binding cassette, subfamily G, member 4,
Abcg4_predicted,
LOC300664,
ATP-binding cassette sub-family G member 4,
ATP-binding cassette, sub-family G (WHITE), member 4,
ATP-binding cassette, sub-family G (WHITE), member 4 (predicted)
|
| Genes |
ABCG4 (Hs), Abcg4 (Mm), Abcg4 (Rn) |
| Ensembl ID |
ENSG00000172350 (Hs), ENSMUSG00000032131 (Mm), ENSRNOG00000008862 (Rn)
|
| Comment |
Putative functional dependence on ABCG1
|
|
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ABCG5
Show »« Hide
| Systematic nomenclature |
ABCG5 |
| Other names |
Sterolin-1,
White3,
STSL,
sterolin 1,
ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1),
ATP-binding cassette sub-family G member 5,
ATP-binding cassette, sub-family G (WHITE), member 5,
ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1),
cmp,
trac
|
| Genes |
ABCG5 (Hs), Abcg5 (Mm), Abcg5 (Rn) |
| Ensembl ID |
ENSG00000138075 (Hs), ENSMUSG00000040505 (Mm), ENSRNOG00000005250 (Rn)
|
| Comment |
Transports phytosterols; forms a heterodimer with ABCG8
|
|
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ABCG8
Show »« Hide
| Systematic nomenclature |
ABCG8 |
| Other names |
Sterolin-2,
GBD4,
ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2),
gallbladder disease 4,
sterolin 2,
ATP-binding cassette sub-family G member 8,
ATP-binding cassette, sub-family G (WHITE), member 8
|
| Genes |
ABCG8 (Hs), Abcg8 (Mm), Abcg8 (Rn) |
| Ensembl ID |
ENSG00000143921 (Hs), ENSMUSG00000024254 (Mm), ENSRNOG00000005420 (Rn)
|
| Comment |
Transports phytosterols; forms a heterodimer with ABCG5
|
|
Comments
Further Reading Show »« Hide
Aye, IL; Singh, AT; Keelan, JA. (2009) Transport of lipids by ABC proteins: interactions and implications for cellular toxicity, viability and function.
Chem. Biol. Interact., 180 (3): 327-39.
[PMID:19426719]
Borst, P; de Wolf, C; van de Wetering, K. (2007) Multidrug resistance-associated proteins 3, 4, and 5.
Pflugers Arch., 453 (5): 661-73.
[PMID:16586096]
Bryan, J; Muñoz, A; Zhang, X; Düfer, M; Drews, G; Krippeit-Drews, P; Aguilar-Bryan, L. (2007) ABCC8 and ABCC9: ABC transporters that regulate K+ channels.
Pflugers Arch., 453 (5): 703-18.
[PMID:16897043]
Ecker, GF; Stockner, T; Chiba, P. (2008) Computational models for prediction of interactions with ABC-transporters.
Drug Discov. Today, 13 (7-8): 311-7.
[PMID:18405843]
Gutmann, DA; Ward, A; Urbatsch, IL; Chang, G; van Veen, HW. (2010) Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.
Trends Biochem. Sci., 35 (1): 36-42.
[PMID:19819701]
Kemp, S; Theodoulou, FL; Wanders, RJ. (2011) Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance.
Br. J. Pharmacol., 164 (7): 1753-66.
[PMID:21488864]
Kerr, ID; Haider, AJ; Gelissen, IC. (2011) The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.
Br. J. Pharmacol., 164 (7): 1767-79.
[PMID:21175590]
Linton, KJ; Higgins, CF. (2007) Structure and function of ABC transporters: the ATP switch provides flexible control.
Pflugers Arch., 453 (5): 555-67.
[PMID:16937116]
Miller, DS. (2010) Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier.
Trends Pharmacol. Sci., 31 (6): 246-54.
[PMID:20417575]
Procko, E; O'Mara, ML; Bennett, WF; Tieleman, DP; Gaudet, R. (2009) The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.
FASEB J., 23 (5): 1287-302.
[PMID:19174475]
Ravna, AW; Sager, G. (2009) Molecular modeling studies of ABC transporters involved in multidrug resistance.
Mini Rev Med Chem, 9 (2): 186-93.
[PMID:19200023]
Rees, DC; Johnson, E; Lewinson, O. (2009) ABC transporters: the power to change.
Nat. Rev. Mol. Cell Biol., 10 (3): 218-27.
[PMID:19234479]
Russel, FG; Koenderink, JB; Masereeuw, R. (2008) Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.
Trends Pharmacol. Sci., 29 (4): 200-7.
[PMID:18353444]
Schrickx, JA; Fink-Gremmels, J. (2008) Implications of ABC transporters on the disposition of typical veterinary medicinal products.
Eur. J. Pharmacol., 585 (2-3): 510-9.
[PMID:18417119]
Seeger, MA; van Veen, HW. (2009) Molecular basis of multidrug transport by ABC transporters.
Biochim. Biophys. Acta, 1794 (5): 725-37.
[PMID:19135557]
Sharom, FJ. (2008) ABC multidrug transporters: structure, function and role in chemoresistance.
Pharmacogenomics, 9 (1): 105-27.
[PMID:18154452]
Szakács, G; Váradi, A; Ozvegy-Laczka, C; Sarkadi, B. (2008) The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
Drug Discov. Today, 13 (9-10): 379-93.
[PMID:18468555]
Wanders, RJ; Visser, WF; van Roermund, CW; Kemp, S; Waterham, HR. (2007) The peroxisomal ABC transporter family.
Pflugers Arch., 453 (5): 719-34.
[PMID:17039367]
References Show »« Hide
1. Bakos, E; Homolya, L. (2007) Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1).
Pflugers Arch., 453 (5): 621-41.
[PMID:17187268]
2. Borst, P; de Wolf, C; van de Wetering, K. (2007) Multidrug resistance-associated proteins 3, 4, and 5.
Pflugers Arch., 453 (5): 661-73.
[PMID:16586096]
3. Chen, ZQ; Dong, J; Ishimura, A; Daar, I; Hinnebusch, AG; Dean, M. (2006) The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors.
J. Biol. Chem., 281 (11): 7452-7.
[PMID:16421098]
4. Elliott, AM; Al-Hajj, MA. (2009) ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome.
Mol. Cancer Res., 7 (1): 79-87.
[PMID:19147539]
5. Hollingworth, P; Harold, D; Sims, R; Gerrish, A; Lambert, JC; Carrasquillo, MM; Abraham, R; Hamshere, ML; Pahwa, JS; Moskvina, V; et al.. (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Nat. Genet., 43 (5): 429-35.
[PMID:21460840]
6. Kamakura, A; Fujimoto, Y; Motohashi, Y; Ohashi, K; Ohashi-Kobayashi, A; Maeda, M. (2008) Functional dissection of transmembrane domains of human TAP-like (ABCB9).
Biochem. Biophys. Res. Commun., 377 (3): 847-51.
[PMID:18952056]
7. Kashiwayama, Y; Seki, M; Yasui, A; Murasaki, Y; Morita, M; Yamashita, Y; Sakaguchi, M; Tanaka, Y; Imanaka, T. (2009) 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.
Exp. Cell Res., 315 (2): 190-205.
[PMID:19010322]
8. Kemp, S; Theodoulou, FL; Wanders, RJ. (2011) Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance.
Br. J. Pharmacol., 164 (7): 1753-66.
[PMID:21488864]
9. Kerr, ID; Haider, AJ; Gelissen, IC. (2011) The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.
Br. J. Pharmacol., 164 (7): 1767-79.
[PMID:21175590]
10. Krishnamurthy, PC; Du, G; Fukuda, Y; Sun, D; Sampath, J; Mercer, KE; Wang, J; Sosa-Pineda, B; Murti, KG; Schuetz, JD. (2006) Identification of a mammalian mitochondrial porphyrin transporter.
Nature, 443 (7111): 586-9.
[PMID:17006453]
11. Oude Elferink, RP; Paulusma, CC. (2007) Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein).
Pflugers Arch., 453 (5): 601-10.
[PMID:16622704]
12. Paytubi, S; Wang, X; Lam, YW; Izquierdo, L; Hunter, MJ; Jan, E; Hundal, HS; Proud, CG. (2009) ABC50 promotes translation initiation in mammalian cells.
J. Biol. Chem., 284 (36): 24061-73.
[PMID:19570978]
13. Pondarre, C; Campagna, DR; Antiochos, B; Sikorski, L; Mulhern, H; Fleming, MD. (2007) Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.
Blood, 109 (8): 3567-9.
[PMID:17192398]
14. Reid, G; Wielinga, P; Zelcer, N; van der Heijden, I; Kuil, A; de Haas, M; Wijnholds, J; Borst, P. (2003) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Proc. Natl. Acad. Sci. U.S.A., 100 (16): 9244-9.
[PMID:12835412]
15. Schatton, T; Murphy, GF; Frank, NY; Yamaura, K; Waaga-Gasser, AM; Gasser, M; Zhan, Q; Jordan, S; Duncan, LM; Weishaupt, C; et al.. (2008) Identification of cells initiating human melanomas.
Nature, 451 (7176): 345-9.
[PMID:18202660]
16. Stieger, B. (2009) Recent insights into the function and regulation of the bile salt export pump (ABCB11).
Curr. Opin. Lipidol., 20 (3): 176-81.
[PMID:19684528]
17. van Roermund, CW; Visser, WF; Ijlst, L; van Cruchten, A; Boek, M; Kulik, W; Waterham, HR; Wanders, RJ. (2008) The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters.
FASEB J., 22 (12): 4201-8.
[PMID:18757502]
18. van Roermund, CW; Visser, WF; Ijlst, L; Waterham, HR; Wanders, RJ. (2011) Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation.
Biochim. Biophys. Acta, 1811 (3): 148-52.
[PMID:21145416]
19. Zuo, Y; Zhuang, DZ; Han, R; Isaac, G; Tobin, JJ; McKee, M; Welti, R; Brissette, JL; Fitzgerald, ML; Freeman, MW. (2008) ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.
J. Biol. Chem., 283 (52): 36624-35.
[PMID:18957418]
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