ABCG subfamily | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

ABCG subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF

Overview

Show »« Hide

This family of ‘half-transporters’ act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. They are associated with cellular export of sterols and phospholipids, as well as exogenous drugs (ABCG2).

Transporters

ABC8 (ABCG1) C Show summary »« Hide summary

Target Id	791
Systematic nomenclature	ABCG1
Common abbreviation	ABC8
Previous and unofficial names	ATP-binding cassette transporter 8 \| ATP-binding cassette sub-family G member 1 \| ATP-binding cassette, sub-family G (WHITE), member 1 \| ATP-binding cassette, subfamily G (WHITE), member 1
Genes	ABCG1 (Hs), Abcg1 (Mm), Abcg1 (Rn)
Ensembl ID	ENSG00000160179 (Hs), ENSMUSG00000024030 (Mm), ENSRNOG00000001158 (Rn)
UniProtKB AC	P45844 (Hs), Q64343 (Mm)
Comment	Transports sterols and choline phospholipids [1]

ABCP (ABCG2) C Show summary »« Hide summary More detailed page

Target Id

792

Systematic nomenclature

ABCG2

Common abbreviation

ABCP

Previous and unofficial names

Genes

ABCG2 (Hs), Abcg2 (Mm), Abcg2 (Rn)

Ensembl ID

ENSG00000118777 (Hs), ENSMUSG00000029802 (Mm), ENSRNOG00000007041 (Rn)

UniProtKB AC

Q9UNQ0 (Hs), Q7TMS5 (Mm), Q80W57 (Rn)

Inhibitors

cyclosporin A pK_i 6.3 [3]

Comment

Exhibits a broad substrate specificity, including urate and haem, as well as multiple synthetic compounds [1]. The functional transporter is likely to be a homodimer, although higher oligomeric states have also been proposed.

ABCG4 C Show summary »« Hide summary

Target Id	793
Systematic nomenclature	ABCG4
Previous and unofficial names	White2 \| ATP-binding cassette, subfamily G, member 4 \| ATP-binding cassette, sub-family G (WHITE), member 4 \| ATP-binding cassette, subfamily G (WHITE), member 4
Genes	ABCG4 (Hs), Abcg4 (Mm), Abcg4 (Rn)
Ensembl ID	ENSG00000172350 (Hs), ENSMUSG00000032131 (Mm), ENSRNOG00000008862 (Rn)
UniProtKB AC	Q9H172 (Hs)
Comment	Putative functional dependence on ABCG1

ABCG5 C Show summary »« Hide summary

Target Id	794
Systematic nomenclature	ABCG5
Previous and unofficial names	White3 \| ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1) \| ATP-binding cassette sub-family G member 5 \| cmp \| trac \| STSL \| ATP-binding cassette, subfamily G (WHITE), member 5
Genes	ABCG5 (Hs), Abcg5 (Mm), Abcg5 (Rn)
Ensembl ID	ENSG00000138075 (Hs), ENSMUSG00000040505 (Mm), ENSRNOG00000005250 (Rn)
UniProtKB AC	Q9H222 (Hs), Q99PE8 (Mm), Q99PE7 (Rn)
Comment	Transports phytosterols and cholesterol; forms an obligate heterodimer with ABCG8 [2]. Loss-of-function mutations in ABCG5 are associated with sitosterolemia (OMIM: 210250).

ABCG8 C Show summary »« Hide summary

Target Id	795
Systematic nomenclature	ABCG8
Previous and unofficial names	GBD4 \| ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) \| gallbladder disease 4 \| ATP-binding cassette sub-family G member 8 \| ATP-binding cassette, subfamily G (WHITE), member 8
Genes	ABCG8 (Hs), Abcg8 (Mm), Abcg8 (Rn)
Ensembl ID	ENSG00000143921 (Hs), ENSMUSG00000024254 (Mm), ENSRNOG00000005420 (Rn)
UniProtKB AC	Q9H221 (Hs), Q9DBM0 (Mm), P58428 (Rn)
Comment	Transports phytosterols and cholesterol; forms an obligate heterodimer with ABCG5. Loss-of-function mutations in ABCG8 are associated with sitosterolemia (OMIM: 210250).

References

Show »« Hide

1. Kerr ID, Haider AJ, Gelissen IC. (2011) The ABCG family of membrane-associated transporters: you don't have to be big to be mighty. Br. J. Pharmacol., 164 (7): 1767-79. [PMID:21175590]

2. Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z et al.. (2016) Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature, 533 (7604): 561-4. [PMID:27144356]

3. Ozvegy C, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, Sarkadi B. (2001) Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem. Biophys. Res. Commun., 285 (1): 111-7. [PMID:11437380]

How to cite this family page

Database page citation:

ABCG subfamily. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=155.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.