cyclosporin A

Ligand Id: 1024
Ligand name cyclosporin A

2D Structure

Classification
Compound class Peptide or derivative
Approved drug? Yes (source: FDA (1983))
IUPAC Name
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
International Nonproprietary Names
INN number INN
5086 ciclosporin
Synonyms
ciclosporin
cyclosporine
cyclosporine A
Neoral®
Sandimmune®
Database Links
CAS Registry No. 59865-13-3 (source: Scifinder)
ChEBI CHEBI:4031
ChEMBL Ligand CHEMBL160
DrugBank Ligand DB00091
PharmGKB Drug PA449167
PubChem CID 5284373
Search Google for chemical match using the InChIKey PMATZTZNYRCHOR-CGLBZJNRSA-N
Search Google for chemicals with the same backbone PMATZTZNYRCHOR
Search PubMed clinical trials ciclosporin
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Search PubMed titles/abstracts ciclosporin
Wikipedia Cyclosporin
Comments
Originally isolated from Tolypocladium inflatum. There is some ambiguity in the literature as to the exact stereochemistry of cyclosporin A. Other common representations on PubChem are CID 5280754, and CID 24883466.