cyclosporin A

Ligand id: 1024

Name: cyclosporin A

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Structure and Physico-chemical Properties

2D Structure
References
1. Dong Z, Ekins S, Polli JE. (2013)
Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP).
Mol. Pharm.10 (3): 1008-19. [PMID:23339484]
2. Fehrenbach T, Cui Y, Faulstich H, Keppler D. (2003)
Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.
Naunyn Schmiedebergs Arch. Pharmacol.368 (5): 415-20. [PMID:14530907]
3. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. (1992)
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Proc. Natl. Acad. Sci. U.S.A.89 (9): 3686-90. [PMID:1373887]
4. Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P. (2012)
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
J. Med. Chem.55 (10): 4740-63. [PMID:22541068]
5. Kim RB, Leake B, Cvetkovic M, Roden MM, Nadeau J, Walubo A, Wilkinson GR. (1999)
Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity.
J. Pharmacol. Exp. Ther.291 (3): 1204-9. [PMID:10565843]
6. Liu J, Farmer Jr JD, Lane WS, Friedman J, Weissman I, Schreiber SL. (1991)
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.
Cell66 (4): 807-15. [PMID:1715244]
7. Ozvegy C, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, Sarkadi B. (2001)
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
Biochem. Biophys. Res. Commun.285 (1): 111-7. [PMID:11437380]
8. Treiber A, Schneiter R, Häusler S, Stieger B. (2007)
Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.
Drug Metab. Dispos.35 (8): 1400-7. [PMID:17496208]
9. Yamamoto Y, Kanazawa T, Shimamura M, Ueki M, Hazato T. (1997)
Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O2- generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils.
Biochem Pharmacol54: 695-701. [PMID:9310346]