Target id: 792

Nomenclature: ABCG2

Abbreviated Name: ABCP

Systematic Nomenclature: ABCG2

Family: ABCG subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ABCG2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group)
Mouse - - Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group)
Rat - - Abcg2 ATP binding cassette subfamily G member 2
Previous and Unofficial Names
BCRP | breast cancer resistance protein | mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP- binding cassette transporter | ABCP | CD338 | ATP-binding cassette protein G2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette, sub-family G (WHITE), member 2 | BCRP1 | breast cancer resistance protein 1 homolog | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | ATP-binding cassette, subfamily G (WHITE), member 2 | ATP-binding cassette
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of wild-type, human ABCG2 in complex with two antigen-binding fragments of 5D3 (5D3-Fab)
PDB Id:  5NJ3
Resolution:  3.8Å
Species:  Human
References:  5

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cyclosporin A Hs Inhibition 6.3 pKi 4
pKi 6.3 (Ki 5x10-7 M) [4]
Description: Inhibition of ABCG2-ATPase activity induced by substrate binding.
KS 176 N/A Inhibition 6.2 pIC50
pIC50 6.2 (IC50 5.9x10-7 M)
Description: Pheo A assay
Ko 143 N/A Inhibition - -
Fumitremorgin C N/A Inhibition - -
View species-specific inhibitor tables
General Comments
ABCG2 causes multidrug resistance in cancer [1-3].


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1. Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M. (1998) A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res., 58 (23): 5337-9. [PMID:9850061]

2. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl. Acad. Sci. U.S.A., 95 (26): 15665-70. [PMID:9861027]

3. Miyake K, Mickley L, Litman T, Zhan Z, Robey R, Cristensen B, Brangi M, Greenberger L, Dean M, Fojo T et al.. (1999) Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res., 59 (1): 8-13. [PMID:9892175]

4. Ozvegy C, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, Sarkadi B. (2001) Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem. Biophys. Res. Commun., 285 (1): 111-7. [PMID:11437380]

5. Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. (2017) Structure of the human multidrug transporter ABCG2. Nature, 546 (7659): 504-509. [PMID:28554189]

How to cite this page

ABCG subfamily: ABCG2. Last modified on 27/06/2018. Accessed on 17/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY,