SLC9 family of sodium/hydrogen exchangers

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Sodium/hydrogen exchangers or sodium/proton antiports are a family of transporters that maintain cellular pH by utilising the sodium gradient across the plasma membrane to extrude protons produced by metabolism, in a stoichiometry of 1 Na+ (in) : 1 H+ (out). Several isoforms, NHE6, NHE7, NHE8 and NHE9 appear to locate on intracellular membranes [5-7]. Li+ and NH4+, but not K+, ions may also be transported by some isoforms. Modelling of the topology of these transporters indicates 12 TM regions with an extended intracellular C-terminus containing multiple regulatory sites.

NHE1 is considered to be a ubiquitously-expressed ‘housekeeping’ transporter. NHE3 is highly expressed in the intestine and kidneys and regulate sodium movements in those tissues. NHE10 is present in sperm [10] and osteoclasts [3]; gene disruption results in infertile male mice [10].


NHE1 (Sodium/hydrogen exchanger 1 / SLC9A1) Show summary »

NHE2 (Sodium/hydrogen exchanger 2 / SLC9A2) Show summary »

NHE3 (Sodium/hydrogen exchanger 3 / SLC9A3) Show summary »

NHE4 (Sodium/hydrogen exchanger 4 / SLC9A4) Show summary »

NHE5 (Sodium/hydrogen exchanger 5 / SLC9A5) Show summary »

NHE6 (Sodium/hydrogen exchanger 6 / SLC9A6) Show summary »

NHE7 (Sodium/hydrogen exchanger 7 / SLC9A7) Show summary »

NHE8 (Sodium/hydrogen exchanger 8 / SLC9A8) Show summary »

NHE9 (Sodium/hydrogen exchanger 9 / SLC9A9) Show summary »

NHA1 (solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 / SLC9B1) Show summary »

NHA2 (solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 / SLC9B2) Show summary »

Sperm-NHE (Sodium/hydrogen exchanger 10 / SLC9C1) Show summary »

NHE11 (Sodium/hydrogen exchanger 11 / SLC9C2) Show summary »


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Further reading

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How to cite this family page

Database page citation:

SLC9 family of sodium/hydrogen exchangers. Accessed on 09/10/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol. 170: 1706–1796.