SLC24 family of sodium/potassium/calcium exchangers

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The sodium/potassium/calcium exchange family of transporters utilize the extracellular sodium gradient to drive calcium and potassium co-transport out of the cell. As is the case for NCX transporters (SLC8A family), NKCX transporters are thought to be bidirectional, with the possibility of calcium influx following depolarization of the plasma membrane. Topological modeling suggests the presence of 10 TM domains, with a large intracellular loop between the fifth and sixth TM regions.

Transporters

NKCX1 (Sodium/potassium/calcium exchanger 1 / SLC24A1) Show summary »

NKCX2 (Sodium/potassium/calcium exchanger 2 / SLC24A2) Show summary »

NKCX3 (Sodium/potassium/calcium exchanger 3 / SLC24A3) Show summary »

NKCX4 (Sodium/potassium/calcium exchanger 4 / SLC24A4) Show summary » More detailed page

NKCX5 (Sodium/potassium/calcium exchanger 5 / SLC24A5) Show summary »

NKCX6 (Sodium/potassium/calcium exchanger 6 / SLC24A6) Show summary »

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References

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How to cite this family page

Database page citation:

SLC24 family of sodium/potassium/calcium exchangers. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=202.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.