SLC33 acetylCoA transporter
Overview 
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Acetylation of proteins is a post-translational modification mediated by specific acetyltransferases, using the donor acetyl CoA. SLC33A1/AT1 is a putative 11 TM transporter present on the endoplasmic reticulum, expressed in all tissues, but particularly abundant in the pancreas [2], which imports cytosolic acetyl CoA into these intracellular organelles.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
|
AcetylCoA transporter
(SLC33A1)
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| Nomenclature |
AcetylCoA transporter |
| Systematic nomenclature |
SLC33A1 |
| Common abbreviation |
AT1 |
| Other names |
ACATN,
SPG42,
AT-1,
AT1,
spastic paraplegia 42 (autosomal dominant),
acetyl-CoA transporter,
acetyl-CoA transporter 1,
acetyl-coenzyme A transporter 1,
acetyl-coenzyme A transporter 1-like,
solute carrier family 33 member 1,
acetyl-coenzyme A transporter
|
| Genes |
SLC33A1 (Hs), Slc33a1 (Mm), Slc33a1 (Rn) |
| Ensembl ID |
ENSG00000169359 (Hs), ENSMUSG00000027822 (Mm), ENSRNOG00000010023 (Rn)
|
| Endogenous substrates |
|
Radioligands
(Kd) |
|
| Stoichiometry |
Unknown
|
|
Comments
Further Reading Show »« Hide
Hirabayashi, Y; Kanamori, A; Nomura, KH; Nomura, K. (2004) The acetyl-CoA transporter family SLC33.
Pflugers Arch., 447 (5): 760-2.
[PMID:12739170]
References Show »« Hide
1. Jonas, MC; Pehar, M; Puglielli, L. (2010) AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.
J. Cell. Sci., 123 (Pt 19): 3378-88.
[PMID:20826464]
2. Kanamori, A; Nakayama, J; Fukuda, MN; Stallcup, WB; Sasaki, K; Fukuda, M; Hirabayashi, Y. (1997) Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter.
Proc. Natl. Acad. Sci. U.S.A., 94 (7): 2897-902.
[PMID:9096318]
3. Lin, P; Li, J; Liu, Q; Mao, F; Li, J; Qiu, R; Hu, H; Song, Y; Yang, Y; Gao, G; et al.. (2008) A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).
Am. J. Hum. Genet., 83 (6): 752-9.
[PMID:19061983]
4. Schlipf, NA; Beetz, C; Schüle, R; Stevanin, G; Erichsen, AK; Forlani, S; Zaros, C; Karle, K; Klebe, S; Klimpe, S; et al.. (2010) A total of 220 patients with autosomal dominant spastic paraplegia do not display mutations in the SLC33A1 gene (SPG42).
Eur. J. Hum. Genet., 18 (9): 1065-7.
[PMID:20461110]
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In heterologous expression studies, acetyl CoA transport through AT1 was inhibited by coenzyme A, but not acetic acid, ATP or UDP-galactose [1]. A loss-of-function mutation in SLC33A1 has been associated with spastic paraplegia (SPG42, [3]), although this observation could not be replicated in a subsequent study [4].