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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.
* Key recommended reading is highlighted with an asterisk
* Bartoloni L, Antonarakis SE. (2004) The human sugar-phosphate/phosphate exchanger family SLC37. Pflugers Arch., 447 (5): 780-3. [PMID:12811562]
* Chou JY, Mansfield BC. (2014) The SLC37 family of sugar-phosphate/phosphate exchangers. Curr Top Membr, 73: 357-82. [PMID:24745989]
* Chou JY, Sik Jun H, Mansfield BC. (2013) The SLC37 family of phosphate-linked sugar phosphate antiporters. Mol. Aspects Med., 34 (2-3): 601-11. [PMID:23506893]
1. Almqvist J, Huang Y, Hovmöller S, Wang DN. (2004) Homology modeling of the human microsomal glucose 6-phosphate transporter explains the mutations that cause the glycogen storage disease type Ib. Biochemistry, 43 (29): 9289-97. [PMID:15260472]
2. Charkoudian LK, Farrella BP, Khosla C. (2012) Natural product inhibitors of glucose-6-phosphate translocase. MedChemComm., 3 (8): 926-931.
3. Chen SY, Pan CJ, Nandigama K, Mansfield BC, Ambudkar SV, Chou JY. (2008) The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic. FASEB J., 22 (7): 2206-13. [PMID:18337460]
4. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY. (2011) SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS ONE, 6 (9): e23157. [PMID:21949678]
Database page citation:
SLC37 family of phosphosugar/phosphate exchangers. Accessed on 05/02/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=224.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.