SLC37 family of phosphosugar/phosphate exchangers
Overview 
Show »« Hide
The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation. The SPX1 glycerol 3-phosphate transporter is predicted to be expressed on mitochondria.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
|
Glycerol-3-phosphate transporter
(SLC37A1)
Show »« Hide
| Nomenclature |
Glycerol-3-phosphate transporter |
| Systematic nomenclature |
SLC37A1 |
| Common abbreviation |
SPX1 |
| Other names |
G3PP,
LOC294321,
Slc37a1_predicted,
glycerol-3-phosphate transporter,
solute carrier family 37 (glycerol-3-phosphate transporter), member 1,
solute carrier family 37 (glycerol-3-phosphate transporter), member 1 (predicted)
|
| Genes |
SLC37A1 (Hs), Slc37a1 (Mm), Slc37a1 (Rn) |
| Ensembl ID |
ENSG00000160190 (Hs), ENSMUSG00000024036 (Mm), ENSRNOG00000001169 (Rn)
|
| Substrates |
|
| Stoichiometry |
Unknown
|
|
|
MGC71430
(SLC37A2)
Show »« Hide
| Nomenclature |
MGC71430 |
| Systematic nomenclature |
SLC37A2 |
| Common abbreviation |
SPX2 |
| Other names |
cAMP-inducible gene 2,
cI2,
FLJ00171,
LOC500973,
RGD1564160,
RGD1564160_predicted,
similar to solute carrier family 37 (glycerol-3-phosphate transporter), member 2,
similar to solute carrier family 37 (glycerol-3-phosphate transporter), member 2 (predicted),
solute carrier family 37 (glycerol-3-phosphate transporter), member 2,
sugar phosphate exchanger 2,
cI-2,
G3PP,
Slc37a1
|
| Genes |
SLC37A2 (Hs), Slc37a2 (Mm), Slc37a2 (Rn) |
| Ensembl ID |
ENSG00000134955 (Hs), ENSMUSG00000032122 (Mm), ENSRNOG00000039390 (Rn)
|
| Stoichiometry |
Unknown
|
|
|
MGC32939
(SLC37A3)
Show »« Hide
| Nomenclature |
MGC32939 |
| Systematic nomenclature |
SLC37A3 |
| Common abbreviation |
SPX3 |
| Other names |
DKFZp761N0624,
LOC312255,
Slc37a3_predicted,
solute carrier family 37 (glycerol-3-phosphate transporter), member 3,
solute carrier family 37 (glycerol-3-phosphate transporter), member 3 (predicted),
sugar phosphate exchanger 3
|
| Genes |
SLC37A3 (Hs), Slc37a3 (Mm), Slc37a3 (Rn) |
| Ensembl ID |
ENSG00000157800 (Hs), ENSMUSG00000029924 (Mm), ENSRNOG00000008725 (Rn)
|
| Stoichiometry |
Unknown
|
|
|
Glucose-6-phosphate transporter
(SLC37A4)
Show »« Hide
| Nomenclature |
Glucose-6-phosphate transporter |
| Systematic nomenclature |
SLC37A4 |
| Common abbreviation |
SPX4 |
| Other names |
G6PT1,
G6PT2,
G6PT3,
GSD1b,
GSD1c,
GSD1d,
glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1,
glucose-6-phosphatase transport protein 1,
glucose-6-phosphatase, transport protein 1,
glucose-6-phosphate translocase,
solute carrier family 37 (glucose-6-phosphate transporter), member 4,
solute carrier family 37 (glycerol-6-phosphate transporter), member 4,
G6PT
|
| Genes |
SLC37A4 (Hs), Slc37a4 (Mm), Slc37a4 (Rn) |
| Ensembl ID |
ENSG00000137700 (Hs), ENSMUSG00000032114 (Mm), ENSRNOG00000011361 (Rn)
|
| Substrates |
|
| Stoichiometry |
Unknown
|
| Comment |
Multiple polymorphisms have been described for the SLC37A4 gene, some of which associate with a glycogen storage disease [1].
|
|
Further Reading Show »« Hide
Bartoloni, L; Antonarakis, SE. (2004) The human sugar-phosphate/phosphate exchanger family SLC37.
Pflugers Arch., 447 (5): 780-3.
[PMID:12811562]
References Show »« Hide
1. Almqvist, J; Huang, Y; Hovmöller, S; Wang, DN. (2004) Homology modeling of the human microsomal glucose 6-phosphate transporter explains the mutations that cause the glycogen storage disease type Ib.
Biochemistry, 43 (29): 9289-97.
[PMID:15260472]
@GuidetoPHARM 
Like us on Facebook 