SLC41 family of divalent cation transporters
By analogy with bacterial orthologues, this family is probably magnesium transporters. The prokaryote orthologue, MgtE, is responsible for uptake of divalent cations, while the heterologous expression studies of mammalian proteins suggest Mg2+ efflux. Topological modelling suggests 10 TM domains with cytoplasmic C- and N- termini.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters 
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Moomaw, AS; Maguire, ME. (2008) The unique nature of mg2+ channels. Physiology (Bethesda), 23: 275-85. [PMID:18927203]
Quamme, GA. (2010) Molecular identification of ancient and modern mammalian magnesium transporters. Am. J. Physiol., Cell Physiol., 298 (3): C407-29. [PMID:19940067]
1. Goytain, A; Quamme, GA. (2005) Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. Physiol. Genomics, 21 (3): 337-42. [PMID:15713785]
2. Goytain, A; Quamme, GA. (2005) Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Biochem. Biophys. Res. Commun., 330 (3): 701-5. [PMID:15809054]
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