SLC45 family of putative sugar transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Members of the SLC45 family remain to be fully characterised. SLC45A1 was initially identified in the rat brain, particularly predominant in the hindbrain, as a proton-associated sugar transport, induced by hypercapnia [3]. The protein is predicted to have 12TM domains, with intracellular termini. The SLC45A2 gene is thought to encode a transporter protein that mediates melanin synthesis. Mutations in SLC45A2 are a cause of oculocutaneous albinism type 4 (e.g. [2]), and polymorphisms in this gene are associated with variations in skin and hair color (e.g. [1]).

Transporters

Proton-associated sugar transporter A / SLC45A1 C Show summary »

Membrane-associated transporter protein / SLC45A2 Show summary »

Solute carrier family 45 member 3 / SLC45A3 Show summary »

Solute carrier family 45 member 4 / SLC45A4 Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC45 family of putative sugar transporters. Accessed on 19/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=234.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.